Results 11 to 20 of about 2,373,510 (375)
AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking [PDF]
Cellular and Molecular Life Sciences, 2019 To correctly transfer information, neuronal networks need to continuously adjust their synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of their function and is, thus, tightly regulated.
Diane Bissen, F. Foss, A. Acker-Palmer
semanticscholar +5 more sources
Stargazin Modulation of AMPA Receptors [PDF]
Cell Reports, 2016 Fast excitatory synaptic signaling in the mammalian brain is mediated by AMPA-type ionotropic glutamate receptors. In neurons, AMPA receptors co-assemble with auxiliary proteins, such as stargazin, which can markedly alter receptor trafficking and gating.
Sana A. Shaikh +7 more
doaj +5 more sources
Regulation of AMPA receptors in spinal nociception [PDF]
Molecular Pain, 2010 The functional properties of α-amino-3-hydroxy-5-methy-4-isoxazole propionate (AMPA) receptors in different brain regions, such as hippocampus and cerebellum, have been well studied in vitro and in vivo. The AMPA receptors present a unique characteristic
Lin Qing +5 more
doaj +3 more sources
Regulation of AMPA Receptors by Phosphorylation [PDF]
Neurochemical Research, 2000 The AMPA receptors for glutamate are oligomeric structures that mediate fast excitatory responses in the central nervous system. Phosphorylation of AMPA receptors is an important mechanism for short-term modulation of their function, and is thought to play an important role in synaptic plasticity in different brain regions.
Carvalho, Ana Luísa +2 more
openaire +4 more sources
AMPA Receptors Bring On the Pain [PDF]
Neuron, 2004 The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Amy B. MacDermott, Carole Torsney
openaire +3 more sources
Nomadic AMPA Receptors and LTP [PDF]
Neuron, 1999 What are the broader implications of these two reports? One feature of LTP is its reversibility: once established, application of low-frequency stimulus train can decrease the synaptic strength. When applied to naive synapyses (i.e., in fresh brain slices), such low frequency stimulation induces a long-lasting depression of synaptic responses known as ...
Miguel Morales, Yukiko Goda
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2022 Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
doaj +1 more source
Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]
, 2006 We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina +8 more
core +1 more source
AMPA receptor trafficking and learning [PDF]
European Journal of Neuroscience, 2010 AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
Zhaoqing Zheng, Joyce Keifer
openaire +3 more sources
Presynaptic AMPA Receptors in Health and Disease [PDF]
Cells, 2021 AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L. +4 more
openaire +4 more sources