Results 11 to 20 of about 2,334,241 (398)
Dysregulation of AMPA Receptor Trafficking and Intracellular Vesicular Sorting in the Prefrontal Cortex of Dopamine Transporter Knock-Out Rats [PDF]
Biomolecules, 2023 Dopamine (DA) and glutamate interact, influencing neural excitability and promoting synaptic plasticity. However, little is known regarding the molecular mechanisms underlying this crosstalk.
Giorgia Targa +5 more
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Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects [PDF]
Biomolecules, 2022 L-Glutamic acid is the main excitatory neurotransmitter in the central nervous system (CNS). Its associated receptors localized on neuronal and non-neuronal cells mediate rapid excitatory synaptic transmission in the CNS and regulate a wide range of ...
Elena A. Golubeva +3 more
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Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics [PDF]
Nature Communications, 2023 AMPA receptors associated with TARP subunits enable the development of selective AMPA receptor drugs. Here, the authors provide cryo-EM structures of receptors bound to three TARP-γ8 selective drugs, and reveal bifunctionality of one ligand.
Danyang Zhang +7 more
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Expression of AMPA and NMDA receptor subunits in the cervical spinal cord of wobbler mice [PDF]
BMC Neuroscience, 2006 Background The localisation of AMPA and NMDA receptor subunits was studied in a model of degeneration of cervical spinal motoneurons, the wobbler mouse. Cervical regions from early or late symptomatic wobbler mice (4 or 12 weeks of age) were compared to ...
Corsi Massimiliano M +8 more
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Cells, 2022 The ionotropic glutamate receptor subtype α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) is responsible for most excitatory transmission in the brain.
Mohammad Qneibi +3 more
doaj +1 more source
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Frontiers in Molecular Neuroscience, 2021 Different families of auxiliary subunits regulate the function and trafficking of native α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the central nervous system. While a facilitatory role of auxiliary subunits in ER export and
Ali Harb +7 more
doaj +1 more source
Nomadic AMPA Receptors and LTP [PDF]
Neuron, 1999 What are the broader implications of these two reports? One feature of LTP is its reversibility: once established, application of low-frequency stimulus train can decrease the synaptic strength. When applied to naive synapyses (i.e., in fresh brain slices), such low frequency stimulation induces a long-lasting depression of synaptic responses known as ...
Miguel Morales, Yukiko Goda
openaire +3 more sources
AMPA Receptors Bring On the Pain [PDF]
Neuron, 2004 The role of Ca(2+)-permeable AMPA receptors in pain processing has not been extensively studied. In this issue of Neuron, Hartmann et al. show that altering the levels of these receptors has consequences for inflammatory pain hypersensitivity but not acute pain processing.
Amy B. MacDermott, Carole Torsney
openaire +3 more sources
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
The early stage formation of PI3K-AMPAR GluR2 subunit complex facilitates the long term neuroprotection induced by propofol post-conditioning in rats. [PDF]
PLoS ONE, 2013 Previously, we have shown that the phosphoinositide-3-kinase (PI3K) mediated acute (24 h) post-conditioning neuroprotection induced by propofol.
Haiyun Wang +6 more
doaj +1 more source