Results 21 to 30 of about 2,334,241 (398)

Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus

Journal of Comparative Neurology, Volume 531, Issue 2, Page 281-293, February 2023., 2023
Hippocampal granule cells of adult mice lacking canonical TNF‐Rs were filled with Alexa568 and immunolabeled for Synaptopodin. Morphometric analysis of their spines revealed that TNF‐R mutants partially replicate changes previously reported for TNF‐deficient mice.
Dinko Smilovic, Michael Rietsche, Meike Fellenz, Alexander Drakew, Mario Vuksic, Thomas Deller   +5 more
wiley   +1 more source

The Impact of Glutamatergic Synapse Dysfunction in the Corticothalamocortical Network on Absence Seizure Generation

Frontiers in Molecular Neuroscience, 2022
Childhood absence epilepsy (CAE) is the most common pediatric epilepsy affecting 10–18% of all children with epilepsy. It is genetic in origin and the result of dysfunction within the corticothalamocortical (CTC) circuitry.
Beulah Leitch
doaj   +1 more source

Presynaptic AMPA Receptors in Health and Disease [PDF]

Cells, 2021
AMPA receptors (AMPARs) are ionotropic glutamate receptors that play a major role in excitatory neurotransmission. AMPARs are located at both presynaptic and postsynaptic plasma membranes. A huge number of studies investigated the role of postsynaptic AMPARs in the normal and abnormal functioning of the mammalian central nervous system (CNS).
Zanetti L., Regoni M., Ratti E., Valtorta F., Sassone J.   +4 more
openaire   +4 more sources

Cortical synapses of the world's smallest mammal: An FIB/SEM study in the Etruscan shrew

Journal of Comparative Neurology, Volume 531, Issue 3, Page 390-414, February 2023., 2023
The present work provides a quantitative dataset of synapses from the Etruscan shrew (the smallest known terrestrial mammal). We have identified common and differing principles of synaptic organization compared to other mammalian species. Abstract The main aim of the present study was to determine if synapses from the exceptionally small brain of the ...
Lidia Alonso‐Nanclares, J. Rodrigo Rodríguez, Angel Merchan‐Perez, Juncal González‐Soriano, Sergio Plaza‐Alonso, Nicolás Cano‐Astorga, Robert K. Naumann, Michael Brecht, Javier DeFelipe   +8 more
wiley   +1 more source

AMPA receptor trafficking and learning [PDF]

European Journal of Neuroscience, 2010
AbstractIn the last few years it has become clear that AMPA‐type glutamate neurotransmitter receptors are rapidly transported into and out of synapses to strengthen or weaken their function. The remarkable dynamics of AMPA receptor (AMPAR) synaptic localization provides a compelling mechanism for understanding the cellular basis of learning and memory,
Zhaoqing Zheng, Joyce Keifer
openaire   +3 more sources

AMPA Receptor Function in Hypothalamic Synapses [PDF]

Frontiers in Synaptic Neuroscience, 2022
AMPA receptors (AMPARs) are critical for mediating glutamatergic synaptic transmission and plasticity, thus playing a major role in the molecular machinery underlying cellular substrates of memory and learning. Their expression pattern, transport and regulatory mechanisms have been extensively studied in the hippocampus, but their functional properties
Maria Royo, Beatriz Aznar Escolano, M. Pilar Madrigal, Sandra Jurado   +3 more
openaire   +5 more sources

Chemokine fractalkine/CX3CL1 negatively modulates active glutamatergic synapses in rat hippocampal neurons [PDF]

, 2006
We examined the effects of the chemokine fractalkine (CX3CL1) on EPSCs evoked by electrical stimulation of Schaffer collaterals in patch-clamped CA1 pyramidal neurons from rat hippocampal slices.
BERTOLLINI, Cristina, CHARO IF, DI ANGELANTONIO, SILVIA, EUSEBI, Fabrizio, GROSS C, LIMATOLA, Cristina, MAGGI, Laura, RAGOZZINO, Davide Antonio, TRETTEL, Flavia   +8 more
core   +1 more source

Gating Modes in AMPA Receptors [PDF]

The Journal of Neuroscience, 2010
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and
Lonnie P. Wollmuth, Martin Loynaz Prieto
openaire   +3 more sources

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting

Science, 2019
Forgetting and receptor removal The trafficking of AMPA receptors to and from the surface of postsynaptic membranes regulates synaptic strength and underlies learning and memory. Awasthi et al.
Ankit Awasthi, Binu Ramachandran, Saheeb Ahmed, E. Benito, Y. Shinoda, Noam Nitzan, A. Heukamp, Sabine Rannio, H. Martens, Jonas Barth, K. Burk, Y. T. Wang, A. Fischer, Camin Dean   +13 more
semanticscholar   +1 more source

Uncorking AMPA receptors [PDF]

Journal of General Physiology, 2017
New JGP study explains how auxiliary proteins relieve polyamine block of AMPARs.
openaire   +2 more sources