Results 21 to 30 of about 2,263,243 (98)

Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking

Journal of Neural Transplantation and Plasticity, 2016
Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and ...
Sumasri Guntupalli, Jocelyn Widagdo, Victor Anggono   +2 more
semanticscholar   +1 more source

GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse

Cell Reports, 2017
Regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking in response to neuronal activity is critical for synaptic function and plasticity.
Sylvia Pfennig, Franziska Foss, Diane Bissen, Eva Harde, Julia C. Treeck, Marta Segarra, Amparo Acker-Palmer   +6 more
doaj   +1 more source

AMPA Receptors: A Key Piece in the Puzzle of Memory Retrieval

Frontiers in Human Neuroscience, 2021
Retrieval constitutes a highly regulated and dynamic phase in memory processing. Its rapid temporal scales require a coordinated molecular chain of events at the synaptic level that support transient memory trace reactivation.
Magdalena Pereyra, Jorge H. Medina, Jorge H. Medina, Jorge H. Medina   +3 more
doaj   +1 more source

Role of the Ion Channel Extracellular Collar in AMPA Receptor Gating

Scientific Reports, 2017
AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor ...
Maria V. Yelshanskaya, Samaneh Mesbahi-Vasey, Maria G. Kurnikova, Alexander I. Sobolevsky   +3 more
doaj   +1 more source

Single-Particle Tracking of AMPA Receptor-Containing Vesicles

Bio-Protocol
AMPA-type receptors are transported large distances to support synaptic plasticity at distal dendritic locations. Studying the motion of AMPA receptor+ vesicles can improve our understanding of the mechanisms that underlie learning and memory ...
Victor Wong, Deepika Walpita, Zhe Liu, Erin O’Shea   +3 more
doaj   +1 more source

p97 regulates GluA1 homomeric AMPA receptor formation and plasma membrane expression

Nature Communications, 2019
AMPA receptors mediate excitatory synaptic transmission and are involved in synaptic plasticity. The authors show that p97 interacts with the GluA1 subunit of AMPA receptors, promotes the formation of GluA1 homomeric AMPA receptors, and regulates AMPA ...
Yuan Ge, Meng Tian, Lidong Liu, Tak Pan Wong, Bo Gong, Dongchuan Wu, Taesup Cho, Shujun Lin, Jürgen Kast, Jie Lu, Yu Tian Wang   +10 more
doaj   +1 more source

Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Frontiers in Cellular Neuroscience, 2013
Paradoxical seizure exacerbation by antiepileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear.
Atul eMaheshwari, Walter eNahm, Jeffrey eNoebels   +2 more
doaj   +1 more source

Visualization of NMDA receptor-dependent AMPA receptor synaptic plasticity in vivo

Nature Neuroscience, 2015
Regulation of AMPA receptor (AMPAR) membrane trafficking is critical for synaptic plasticity, as well as for learning and memory. However, the mechanisms of AMPAR trafficking in vivo remain elusive.
Yong Zhang, Robert H. Cudmore, Da-Ting Lin, D. Linden, R. Huganir   +4 more
semanticscholar   +1 more source

Memory Retrieval Requires Ongoing Protein Synthesis and NMDA Receptor Activity-Mediated AMPA Receptor Trafficking

Journal of Neuroscience, 2015
Whereas consolidation and reconsolidation are considered dynamic processes requiring protein synthesis, memory retrieval has long been considered a passive readout of previously established plasticity.
Joëlle Lopez, Karine Gamache, Rilla Schneider, K. Nader   +3 more
semanticscholar   +1 more source

Seizure control by decanoic acid through direct AMPA receptor inhibition

Brain : a journal of neurology, 2015
See Rogawski (doi:10.1093/awv369) for a scientific commentary on this article.  The MCT ketogenic diet, an established treatment for drug-resistant epilepsy, leads to an elevation of plasma decanoic acid and ketones. Chang et al. show that decanoic acid,
P. Chang, Katrin Augustin, Kim Boddum, Sophie Williams, Minghao Sun, J. Terschak, J. Hardege, Philip E. Chen, M. Walker, Robin S. B. Williams   +9 more
semanticscholar   +1 more source