Results 111 to 120 of about 85,510 (321)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Why Abeta42 Is Much More Toxic Than Abeta40 [PDF]

arXiv, 2018
Amyloid precursor with 770 amino acids dimerizes and aggregates, as do its c terminal 99 amino acids and amyloid 40,42 amino acids fragments. The titled question has been discussed extensively, and here it is addressed further using thermodynamic scaling theory to analyze mutational trends in structural factors and kinetics.
arxiv  

Crucial role of non-specific interactions in amyloid nucleation [PDF]

, 2014
Protein oligomers have been implicated as toxic agents in a wide range of amyloid-related diseases. Yet it has remained unsolved whether the oligomers are a necessary step in the formation of amyloid fibrils, or just a dangerous by-product. Analogously, it has not been resolved if the amyloid nucleation process is a classical one-step nucleation ...
arxiv   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein. [PDF]

, 2018
Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used
Fong, Lauren K, Frankowski, Harald, Goldstein, Lawrence SB, Petsko, Gregory A, Small, Scott A, Young, Jessica E   +5 more
core   +3 more sources

Crystallization of L‐Cysteine in Heavy Water Induces Intrinsic Fluorescence

Angewandte Chemie, EarlyView.
Crystallization of L‐Cysteine in D2O${\rm D}_2{\rm O}$ generates a remarkably different structure compared to H2O${\rm H}_2{\rm O}$. The crystals formed in D2O${\rm D}_2{\rm O}$ display enhanced intrinsic fluorescence, and using state‐of‐the‐art excited state simulations, we determine the molecular origins of this luminescence and propose design ...
Debarshi Banerjee, Sonika Chibh, Om Shanker Tiwari, Gonzalo Díaz Mirón, Marta Monti, Hadar R. Yakir, Shweta Pawar, Dror Fixler, Linda J. W. Shimon, Ehud Gazit, Ali Hassanali   +10 more
wiley   +2 more sources

Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Frontiers in Pharmacology, 2020
Alzheimer’s disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients.
Md. Habibur Rahman, Rokeya Akter, Tanima Bhattacharya, Mohamed M. Abdel-Daim, Mohamed M. Abdel-Daim, Saad Alkahtani, Mohammed W. Arafah, Norah S. Al-Johani, Norah M. Alhoshani, Nora Alkeraishan, Alhanof Alhenaky, Omar H. Abd‐Elkader, Hesham R El-Seedi, Hesham R El-Seedi, Deepak Kaushik, Vineet Mittal   +15 more
doaj   +1 more source

Cancer Specific CAIX‐Targeting Supramolecular Lysosome‐Targeting Chimeras (Supra‐LYTAC) for Targeted Protein Degradation

Advanced Science, EarlyView.
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim, Gyeongseok Yang, Chaelyeong Lim, Gaeun Park, Jaemo Lee, Youjung Sim, Ja‐Hyoung Ryu   +6 more
wiley   +1 more source

Mechanical Characterization of Amyloid Fibrils Using Coarse-Grained Normal Mode Analysis [PDF]

Advanced Functional Materials 2011, 2011
Recent experimental studies have shown that amyloid fibril formed by aggregation of {\beta} peptide exhibits excellent mechanical properties comparable to other protein materials such as actin filaments and microtubules. These excellent mechanical properties of amyloid fibrils are related to their functional role in disease expression.
arxiv  

Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer’s Disease

Biomolecules, 2020
Alzheimer’s disease is a neurodegenerative disorder for which there is a continuous search of drugs able to reduce or stop the cognitive decline. Beta-amyloid peptides are composed of 40 and 42 amino acids and are considered a major cause of neuronal ...
Raluca Stefanescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Luminita Paduraru, Bogdan-Ionel Tamba   +4 more
doaj   +1 more source