Results 11 to 20 of about 120,218 (348)

Early Divergence in Misfolding Pathways of Amyloid-Beta Peptides. [PDF]

Chemphyschem, 2021
AbstractThe amyloid cascade hypothesis proposes that amyloid‐beta (Aβ) aggregation is the initial triggering event in Alzheimer's disease. Here, we utilize NMR spectroscopy and monitor the structural dynamics of two variants of Aβ, Aβ40 and Aβ42, as a function of temperature.
Mamone S, Glöggler S, Becker S, Rezaei-Ghaleh N.   +3 more
europepmc   +6 more sources

Adsorption of Amyloid Beta Peptide by Metal–Organic Frameworks [PDF]

ACS Omega, 2020
Metal-organic frameworks (MOFs) are capable of adsorbing a wide range of molecules. In addition to the more commonly investigated small molecules, researchers have demonstrated that MOFs adsorb much larger molecules, such as proteins and peptides. We have investigated whether MOFs are capable of adsorbing amyloid beta peptide.
Zachary L. Mensinger, Brenna L. Cook, Elsie L. Wilson   +2 more
openalex   +4 more sources

Characterizing Heparin Tetrasaccharides Binding to Amyloid-Beta Peptide [PDF]

Frontiers in Molecular Biosciences, 2022
The aggregation of β-amyloid peptide (Aβ) is one potential cause for Alzheimer’s disease (AD). Heparin can either promote or inhibit Aβ aggregation. The sulfation pattern and chain size determine its binding affinity and its role. Using 2D-NMR analysis and molecular modelling, the binding motif of heparin oligoaccharides to Aβ was determined to be HexA-
Xiang Zhou, Yuanyuan Wang, Wei Zheng, Guangxiu Deng, Fuyi Wang, Lan Jin   +5 more
openaire   +3 more sources

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

Frontiers in Aging Neuroscience, 2020
Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel, Diana Trujillo-Rodriguez, Andres Villegas, Johannes Streffer, Marc Mercken, Francisco Lopera, Markus Glatzel, Diego Sepulveda-Falla   +7 more
doaj   +1 more source

Astrocytic Redox Remodeling by Amyloid Beta Peptide [PDF]

Antioxidants & Redox Signaling, 2011
Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response signature provoked by amyloid beta (Aβ) is distinct from that of a general oxidant (tertiary-butylhydroperoxide [t-BuOOH]).
Garg, Sanjay K., Vitvitsky, Victor M., Albin, Roger L., Banerjee, Ruma   +3 more
openaire   +3 more sources

Casuarictin: A new herbal drug molecule for Alzheimer's disease as inhibitor of presenilin stabilization factor like protein

Heliyon, 2020
Alzheimer's disease is a progressive neurodegenerative disorder. In this disease neurodegeneration occurs due to deposition of aggregated amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau proteins).
Rupali Kumari, Amit Chaudhary, Ashutosh Mani   +2 more
doaj   +1 more source

Insight into the structure of amyloid fibrils from the analysis of globular proteins. [PDF]

PLoS Computational Biology, 2006
The conversion from soluble states into cross-beta fibrillar aggregates is a property shared by many different proteins and peptides and was hence conjectured to be a generic feature of polypeptide chains.
Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno   +3 more
doaj   +1 more source

Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]

, 2007
The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria, Hamley, Ian W., Krysmann, M.J.   +2 more
core   +1 more source

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Molecules, 2019
Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain
Raluca Ştefănescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Ioana Cezara Caba, Bogdan Ionel Tamba, Cosmin Teodor Mihai   +5 more
doaj   +1 more source

Oxidation destabilizes toxic amyloid beta peptide aggregation [PDF]

Scientific Reports, 2019
AbstractThe aggregation of insoluble amyloid beta (Aβ) peptides in the brain is known to trigger the onset of neurodegenerative diseases, such as Alzheimer’s disease. In spite of the massive number of investigations, the underlying mechanisms to destabilize the Aβ aggregates are still poorly understood. Some studies indicate the importance of oxidation
J. Razzokov, M. Yusupov, A. Bogaerts
openaire   +3 more sources