Results 11 to 20 of about 85,510 (321)

DHA supplemented in peptamen diet offers no advantage in pathways to amyloidosis: is it time to evaluate composite lipid diet? [PDF]

PLoS ONE, 2011
Numerous reports have documented the beneficial effects of dietary docosahexaenoic acid (DHA) on beta-amyloid production and Alzheimer's disease (AD).
Zareen Amtul, Mary Keet, Lin Wang, Peter Merrifield, David Westaway, Richard F Rozmahel   +5 more
doaj   +6 more sources

Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro [PDF]

Molecules, 2020
Alzheimer’s disease (AD) and Parkinson’s disease (PD), including dementia with Lewy bodies (DLB), account for the majority of dementia cases worldwide.
Janett Köppen, Anja Schulze, Lisa Machner, Michael Wermann, Rico Eichentopf, Max Guthardt, Angelika Hähnel, Jessica Klehm, Marie-Christin Kriegeskorte, Maike Hartlage-Rübsamen, Markus Morawski, Stephan von Hörsten, Hans-Ulrich Demuth, Steffen Roßner, Stephan Schilling   +14 more
doaj   +2 more sources

Coenzyme Q10 Enhances Resilience of Mitochondrial-like Membranes Against Amyloidogenic Peptides [PDF]

Membranes
Mitochondria possess a double-membrane envelope which is susceptible to insult by pathogenic intracellular aggregates of amyloid-forming peptides, such as the amyloid-beta (1-42) (Aβ42) peptide and the human islet amyloid polypeptide (hIAPP).
Raina Marie Seychell, Adam El Saghir, Gianluca Farrugia, Neville Vassallo   +3 more
doaj   +2 more sources

The aggregation tendencies of the signal peptide regions of prone and not prone to aggregate proteins [PDF]

Biochemistry and Biophysics Reports
Signal peptides are a sequence of peptides located at the N-terminus of proteins and determine the protein secretion pathway and their destinations. The N-region is positively charged and influences the orientation of translocation.
Natalie G. Horgan, Anabela Djurovic-Topalovic, Taiwo A. Ademoye, Jessica S. Fortin   +3 more
doaj   +2 more sources

Pilot Study: Lymphatic Brain Decongestion: A New Surgical Technique in Alzheimer Disease [PDF]

Plastic and Reconstructive Surgery, Global Open
Background:. Alzheimer disease (AD) is characterized by progressive cognitive function decline and neurodegeneration. Accumulation of amyloid-beta peptides forms plaques leading to brain inflammation and neuronal death. Glymphatic and meningeal lymphatic
Anastasios Topalis, MD, Chrysanthi Bekiari, PhD, Efterpi Demiri, MD, PhD, Dimitrios Dionyssiou, MD, PhD   +3 more
doaj   +2 more sources

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
core   +8 more sources

Engineering neprilysin activity and specificity to create a novel therapeutic for Alzheimer's disease. [PDF]

PLoS ONE, 2014
Neprilysin is a transmembrane zinc metallopeptidase that degrades a wide range of peptide substrates. It has received attention as a potential therapy for Alzheimer's disease due to its ability to degrade the peptide amyloid beta.
Carl I Webster, Matthew Burrell, Lise-Lotte Olsson, Susan B Fowler, Sarah Digby, Alan Sandercock, Arjan Snijder, Jan Tebbe, Ulrich Haupts, Joanna Grudzinska, Lutz Jermutus, Christin Andersson   +11 more
doaj   +1 more source

The orphan drug dichloroacetate reduces amyloid beta-peptide production whilst promoting non-amyloidogenic proteolysis of the amyloid precursor protein.

PLoS ONE, 2022
The amyloid cascade hypothesis proposes that excessive accumulation of amyloid beta-peptides is the initiating event in Alzheimer's disease. These neurotoxic peptides are generated from the amyloid precursor protein via sequential cleavage by β- and γ ...
Edward T Parkin, Jessica E Hammond, Lauren Owens, Matthew D Hodges   +3 more
doaj   +1 more source

Early Treatment Critical: Bexarotene Reduces Amyloid-Beta Burden In Silico. [PDF]

PLoS ONE, 2016
Amyloid-beta peptides have long been implicated in the pathology of Alzheimer's disease. Bexarotene, a drug approved by the U.S. Food and Drug Administration for treating a class of non-Hodgkin's lymphoma, has been reported to facilitate the removal of ...
Joseph Rosenthal, Georges Belfort, David Isaacson   +2 more
doaj   +1 more source

Ammonium Sulfate and Ultrafine Particles Affect Early Onset of Alzheimer’s Disease

Chemical Engineering Transactions, 2021
Recent environmental studies have shown the impact of air quality on human health and in particular, toxicological effect of particulate matter (PM) and ultrafine particles (UFPs) on progression of neurodegenerative diseases.
Samal Kaumbekova, Mehdi Amouei Torkmahalleh, Dhawal Shah   +2 more
doaj   +1 more source