Results 11 to 20 of about 118,464 (350)

Early Divergence in Misfolding Pathways of Amyloid-Beta Peptides. [PDF]

Chemphyschem, 2021
AbstractThe amyloid cascade hypothesis proposes that amyloid‐beta (Aβ) aggregation is the initial triggering event in Alzheimer's disease. Here, we utilize NMR spectroscopy and monitor the structural dynamics of two variants of Aβ, Aβ40 and Aβ42, as a function of temperature.
Mamone S, Glöggler S, Becker S, Rezaei-Ghaleh N.   +3 more
europepmc   +6 more sources

Adsorption of Amyloid Beta Peptide by Metal–Organic Frameworks [PDF]

ACS Omega, 2020
Metal-organic frameworks (MOFs) are capable of adsorbing a wide range of molecules. In addition to the more commonly investigated small molecules, researchers have demonstrated that MOFs adsorb much larger molecules, such as proteins and peptides. We have investigated whether MOFs are capable of adsorbing amyloid beta peptide.
Zachary L. Mensinger, Brenna L. Cook, Elsie L. Wilson   +2 more
openalex   +4 more sources

Amyloid-β acts as a regulator of neurotransmitter release disrupting the interaction between synaptophysin and VAMP2. [PDF]

, 2012
BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer's disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42).
Alifragis, P, Austen, BM, Beesley, PW, Empson, RM, Russell, CL, Semerdjieva, S   +5 more
core   +10 more sources

Casuarictin: A new herbal drug molecule for Alzheimer's disease as inhibitor of presenilin stabilization factor like protein

Heliyon, 2020
Alzheimer's disease is a progressive neurodegenerative disorder. In this disease neurodegeneration occurs due to deposition of aggregated amyloid-beta plaques and neurofibrillary tangles (hyperphosphorylated tau proteins).
Rupali Kumari, Amit Chaudhary, Ashutosh Mani   +2 more
doaj   +1 more source

Insight into the structure of amyloid fibrils from the analysis of globular proteins. [PDF]

PLoS Computational Biology, 2006
The conversion from soluble states into cross-beta fibrillar aggregates is a property shared by many different proteins and peptides and was hence conjectured to be a generic feature of polypeptide chains.
Antonio Trovato, Fabrizio Chiti, Amos Maritan, Flavio Seno   +3 more
doaj   +1 more source

Contributions of Mass Spectrometry to the Identification of Low Molecular Weight Molecules Able to Reduce the Toxicity of Amyloid-β Peptide to Cell Cultures and Transgenic Mouse Models of Alzheimer’s Disease

Molecules, 2019
Alzheimer’s Disease affects approximately 33 million people worldwide and is characterized by progressive loss of memory at the cognitive level. The formation of toxic amyloid oligomers, extracellular amyloid plaques and amyloid angiopathy in brain
Raluca Ştefănescu, Gabriela Dumitriṭa Stanciu, Andrei Luca, Ioana Cezara Caba, Bogdan Ionel Tamba, Cosmin Teodor Mihai   +5 more
doaj   +1 more source

Astrocytic Redox Remodeling by Amyloid Beta Peptide [PDF]

Antioxidants & Redox Signaling, 2011
Astrocytes are critical for neuronal redox homeostasis providing them with cysteine needed for glutathione synthesis. In this study, we demonstrate that the astrocytic redox response signature provoked by amyloid beta (Aβ) is distinct from that of a general oxidant (tertiary-butylhydroperoxide [t-BuOOH]).
Garg, Sanjay K., Vitvitsky, Victor M., Albin, Roger L., Banerjee, Ruma   +3 more
openaire   +3 more sources

Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]

, 2009
The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
core   +1 more source

Characterizing Heparin Tetrasaccharides Binding to Amyloid-Beta Peptide [PDF]

Frontiers in Molecular Biosciences, 2022
The aggregation of β-amyloid peptide (Aβ) is one potential cause for Alzheimer’s disease (AD). Heparin can either promote or inhibit Aβ aggregation. The sulfation pattern and chain size determine its binding affinity and its role. Using 2D-NMR analysis and molecular modelling, the binding motif of heparin oligoaccharides to Aβ was determined to be HexA-
Xiang Zhou, Yuanyuan Wang, Wei Zheng, Guangxiu Deng, Fuyi Wang, Lan Jin   +5 more
openaire   +3 more sources

The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity

Neural Regeneration Research, 2013
Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to ...
Wang, Xu, Yang, Yi, Jia, Mingyue, Ma, Chi, Wang, Mingyu, Che, Lihe, Yang, Yu, Wu, Jiang   +7 more
openaire   +2 more sources