Results 251 to 260 of about 45,801 (303)
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Amyloid beta peptides electrochemistry: A review
Current Opinion in Electrochemistry, 2022Abstract Alzheimer disease is a progressive age-related neurodegenerative disorder estimated to affect up to 107 million people by 2050, its pathology is associated with the dysfunction of the amyloid beta (Aβ) peptide mechanism, among others. Electrochemical methods were successfully applied for Aβ electrochemical characterisation and have received ...
Ana-Maria Chiorcea-Paquim +1 more
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Cholesterol Trafficking and Amyloid Beta Peptides
Pharmacopsychiatry, 2003Currently, there is much interest in the association between cholesterol and Alzheimer's disease. An especially important aspect of this association is the relationship between amyloid beta-peptide (Abeta) and cholesterol that can be described as a reciprocal process.
W G, Wood, U, Igbavboa
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Neprilysin and Amyloid Beta Peptide Degradation
Current Alzheimer Research, 2008Neprilysin is a zinc metalloendopeptidase with relatively broad substrate specificity. The enzyme is localized to the plasma membrane of cells where it can function to degrade extracellular peptides. Structural studies show that neprilysin preferentially cleaves peptides on the amino side of hydrophobic amino acids.
Louis B, Hersh, David W, Rodgers
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Cholesterol Modulates Amyloid Beta-peptide’s Membrane Interactions
Pharmacopsychiatry, 2003The causal relationship between amyloid beta-peptide (Abeta) deposition and Alzheimer's disease (AD)-specific neuropathological lesions such as neurodegeneration and cortical atrophy is still not known. Mounting evidence points to alterations in cholesterol homeostasis occurring in AD brain that are probably linked to cerebral Abeta pathology ...
Gunter P, Eckert +4 more
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Amyloid beta peptides and glutamatergic synaptic dysregulation
Experimental Neurology, 2008Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of glutamatergic synaptic ...
Kodeeswaran, Parameshwaran +2 more
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Amyloid beta peptide directly inhibits PKC activation
Molecular and Cellular Neuroscience, 2004A putative protein kinase C (PKC) pseudosubstrate domain in beta amyloid (Abeta) suggests a potential interaction between Abeta and PKC. In this study, we investigated whether and how Abeta interacts with PKC. Abeta peptides inhibited PKC phosphorylation in a dose-dependent manner in cell-free in vitro condition, suggesting a direct interaction between
Lee, W +6 more
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Amyloid beta peptide immunotherapy in Alzheimer disease
Revue Neurologique, 2014Recent advances in the understanding of Alzheimer's disease pathogenesis have led to the development of numerous compounds that might modify the disease process. Amyloid β peptide represents an important molecular target for intervention in Alzheimer's disease.
J, Delrieu +3 more
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Amyloid Beta Peptide Folding in Reverse Micelles
Journal of the American Chemical Society, 2017Previously published experimental studies have suggested that when the 40-residue amyloid beta peptide is encapsulated in a reverse micelle, it folds into a structure that may nucleate amyloid fibril formation (Yeung, P. S.-W.; Axelsen, P. H. J. Am. Chem. Soc. 2012, 134, 6061 ).
Gözde Eskici, Paul H Axelsen
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Electrochemistry of Alzheimer Disease Amyloid Beta Peptides
Current Medicinal Chemistry, 2018Alzheimer’s disease (AD) is a widespread form of dementia that is estimated to affect 44.4 million people worldwide. AD pathology is closely related to the accumulation of amyloid beta (Aβ) peptides in fibrils and plagues, the small oligomeric intermediate species formed during the Aβ peptides aggregation presenting the highest neurotoxicity ...
Ana-Maria, Chiorcea-Paquim +2 more
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Amyloid Beta Peptide, 4-Hydroxynonenal and Apoptosis
Current Alzheimer Research, 2006Considerable evidence suggests a role for oxidative stress in the pathogenesis of neuron degeneration in several neurodegenerative disorders including Alzheimer's disease (AD). Although debated, increasing evidence suggests that oxidative stress/damage (amyloid beta peptide, iron/hydrogen peroxide) or neurotoxic by-products of lipid peroxidation (4 ...
Mark A, Lovell, William R, Markesbery
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