Fibrillisation of hydrophobically modified amyloid peptide fragments in an organic solvent [PDF]
, 2007 The self-assembly of a hydrophobically modified fragment of the amyloid beta(A beta) peptide has been studied in methanol. The peptide FFKLVFF is based on A beta(16-20) extended at the N terminus by two phenylalanine residues.
Castelletto, Valeria +2 more
core +1 more source
Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis
Scientific Reports, 2023 The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku +10 more
doaj +1 more source
Naturally occurring autoantibodies against beta-amyloid: investigating their role in transgenic animal and in vitro models of Alzheimer's disease [PDF]
, 2011 Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in animal models of AD has been shown to be effective on the molecular level
Al-Abed, Yousef +13 more
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Analyzing Amyloid Beta Aggregates with a Combinatorial Fluorescent Molecular Sensor
Proceedings, 2017 The self-assembly of amyloid beta (Aβ) peptides into insoluble aggregates is thought to play a [...]
Joydev Hatai +2 more
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A Condensation-Ordering Mechanism in Nanoparticle-Catalyzed Peptide Aggregation [PDF]
, 2009 Nanoparticles introduced in living cells are capable of strongly promoting the aggregation of peptides and proteins. We use here molecular dynamics simulations to characterise in detail the process by which nanoparticle surfaces catalyse the self ...
A Aggeli +62 more
core +6 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
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d-Amino Acid Pseudopeptides as Potential Amyloid-Beta Aggregation Inhibitors
Molecules, 2018 A causative factor for neurotoxicity associated with Alzheimer’s disease is the aggregation of the amyloid-β (Aβ) peptide into soluble oligomers.
Banafsheh Mehrazma +3 more
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Passive Aβ Immunotherapy: Current Achievements and Future Perspectives
Molecules, 2018 Passive immunotherapy has emerged as a very promising approach for the treatment of Alzheimer’s disease and other neurodegenerative disorders, which are characterized by the misfolding and deposition of amyloid peptides. On the basis of the amyloid
Stephan Schilling +3 more
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Autoxidation Enhances Anti-Amyloid Potential of Flavone Derivatives
Antioxidants, 2021 The increasing prevalence of amyloid-related disorders, such as Alzheimer’s or Parkinson’s disease, raises the need for effective anti-amyloid drugs. It has been shown on numerous occasions that flavones, a group of naturally occurring anti-oxidants, can
Andrius Sakalauskas +3 more
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Amyloid-.BETA. peptide metabolism and Alzheimer's disease
Folia Pharmacologica Japonica, 2003 The deposition of amyloid-beta peptide (Abeta) causes the long-term pathological cascade of Alzheimer's disease (AD). Neprilysin is a rate-limiting peptidase, which participates in Abeta degradation in brain. As demonstrated by reverse genetics, the disruption of neprilysin gene causes an elevation in endogenous Abeta levels in the mouse brain in a ...
Nobuhisa, Iwata, Takaomi C, Saido
openaire +3 more sources