Results 171 to 180 of about 122,310 (350)

Prevalence and Modifiable Risk Factors of Dementia in People With Down Syndrome: Cross‐Sectional Study of Japan in Collaboration With the Intellectual Diversity for Goodness Research Consortium (INDIGO‐2019)

Journal of Intellectual Disability Research, EarlyView.
ABSTRACT Background People with Down syndrome (DS) have a strong genetic predisposition to Alzheimer's disease (AD). However, the clinical burden and associated risk factors in diverse, non‐Western populations remain less understood. This study aimed to investigate the prevalence of dementia in Japanese adults with DS and to identify modifiable ...
Shintaro Takenoshita, Seishi Terada, Tomokazu Inoue, Taku Kurozumi, Manabu Takaki, Ryozo Kuwano, Shigeru Suemitsu   +6 more
wiley   +1 more source

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor.

, 1994
Jean‐Marc Roch, Eliezer Masliah, Anne‐Catherine Roch‐Levecq, Mary Sundsmo, D A Otero, Isaac Veinbergs, T Saitoh   +6 more
openalex   +2 more sources

Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs

Journal of Anatomy, EarlyView.
The expression of various genes involved in synapse development, stability and/or function was studied in developing mechanosensory neuromasts and electrosensory ampullary organs in sterlet sturgeon. Most were shared, including Slc17a8, Slc1a3 and Nrxn3, but Cbln18 was neuromast‐restricted and Tulp1 was ampullary organ‐restricted.
Alexander S. Campbell, Martin Minařík, David Buckley, Tanmay Anand, David Gela, Martin Pšenička, Clare V. H. Baker   +6 more
wiley   +1 more source

Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging [PDF]

, 2018
Chen, Wei, Gao, Fabao, Song, Li, Tao, Chuanyuan, Wang, Chunhua, Wang, Yu, Xu, Ziqian, Zhang, Ruzhi, Zheng, Jie   +8 more
core   +2 more sources

Mapping 60 Years of Discovery: An AI‐Driven Bibliometric and Altmetric Analysis of the Journal of Periodontal Research

Journal of Periodontal Research, EarlyView.
AI, particularly the large language model GPT‐5‐mini, demonstrated reliable performance in labeling research topics and levels of evidence. Over the past 60 years, JPR has made a substantial contribution to the periodontal literature, generating meaningful public and societal impact, and it is expected to experience exponential growth in the coming ...
Parham Hazrati, Tara Zibandehkhooy, Hamoun Sabri, Mario Romandini, Shayan Barootchi   +4 more
wiley   +1 more source

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

, 1991
Mark J. Adler, Carlos E. Coronel, Earl R. Shelton, J. Edwin Seegmiller, Nazneen N. Dewji   +4 more
openalex   +2 more sources

Gut proteome and microbiome alterations: Analysis of transverse colon samples from pathologically confirmed Alzheimer's disease patients. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Alzheimer's disease (AD) has been regarded as a brain‐first disorder. Emerging evidence suggests that the gut may influence central nervous system pathology, but the mechanisms remain unclear. METHODS We conducted a proteomic and microbial analysis of transverse colon samples from clinically and pathologically confirmed AD and ...
Cheng Q, Nolz J, Karr T, Dorn N, Readhead B, Krajmalnik-Brown R, Mastroeni D.   +6 more
europepmc   +2 more sources

Homocysteine metabolism is associated with cerebrospinal fluid levels of soluble amyloid precursor protein and amyloid beta [PDF]

, 2016
Aikaterini Oikonomidi, Piotr Lewczuk, Johannes Kornhuber, Yvo M. Smulders, Michael Linnebank, Alexander Semmler, Julius Popp   +6 more
openalex   +1 more source

Novel murine closed‐loop auditory stimulation paradigm elicits macrostructural sleep benefits in neurodegeneration

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Boosting slow‐wave activity (SWA) by modulating slow waves through closed‐loop auditory stimulation (CLAS) might provide a powerful non‐pharmacological tool to investigate the link between sleep and neurodegeneration. Here, we established mouse CLAS (mCLAS)‐mediated SWA enhancement and explored its effects on sleep deficits in neurodegeneration,
Inês Dias, Sedef Kollarik, Michelle Siegel, Christian R. Baumann, Carlos G. Moreira, Daniela Noain   +5 more
wiley   +1 more source

Protease nexin-2/amyloid beta-protein precursor: a cerebral anticoagulant? [PDF]

Journal of Clinical Investigation, 1993
openaire   +1 more source