Results 221 to 230 of about 94,035 (378)

Amyloid-beta metabolism in age-related neurocardiovascular diseases. [PDF]

Eur Heart J
Aivalioti E, Georgiopoulos G, Tual-Chalot S, Bampatsias D, Delialis D, Sopova K, Drakos SG, Stellos K, Stamatelopoulos K.   +8 more
europepmc   +1 more source

Downregulation of forkhead box O1 (FOXO1) acetylation ameliorates cognitive dysfunction by inhibiting endoplasmic reticulum stress‐regulated neuronal apoptosis in APP/PS1 transgenic mice

Neuroprotection, EarlyView.
Downregulation of the expression of silent information regulator sirtuin 1 (SIRT1) exacerbates neuronal degeneration and loss by activating forkhead box O1 (FOXO1) acetylation and promoting endoplasmic reticulum stress (ERSA)‐mediated apoptosis in aging.
Nan Zhang, Zongyuan Zhao, Xiaoxiao Chen, Hanbing Yao, Min Zhu, Shuqing Ma, Hui Wang, Xianghong Yin, Ying Zhou, Chenfei Zheng, Jianmin Li, Jingye Pan, Kaicheng Wang, Bin Yang, Yunting Wang, Junming Fan, Yongsheng Gong, Rong Liu, Jing Zeng, Xiaofang Fan, Yangping Shentu   +20 more
wiley   +1 more source

Research progress on the correlation between islet amyloid peptides and type 2 diabetes mellitus. [PDF]

Open Med (Wars)
Li G, Zhang D.
europepmc   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

5xFAD mice do not have myenteric amyloidosis, dysregulation of neuromuscular transmission or gastrointestinal dysmotility

Neurogastroenterology &Motility, Volume 34, Issue 12, December 2022., 2022
Amyloidosis in central and enteric nervous system contribute to congenic impairment and gastrointestinal dysmotility in Alzheimer's Disease (AD). 5xFAD mice, a transgenic mouse model of AD, mimic the amyloidosis in central nervous system but lacking amyloidosis in enteric nervous system. Abstract Background Alterations in gastrointestinal (GI) function
Narayana Krishna Yelleswarapu, Marlene Masino, Skye Henderson, Roxanne Fernandes, Greg Swain, James J. Galligan, Hui Xu   +6 more
wiley   +1 more source

Colovesical Fistula and Amyloidosis. [PDF]

Cureus
Leng S, Ong WM, Mohd Rosli R, Fernando T, An V.   +4 more
europepmc   +1 more source

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor. [PDF]

, 1989
D.R. Rosen, L Martin-Morris, L Q Luo, K. Andrew White   +3 more
openalex   +1 more source

Blood-brain barrier disruption and perivascular beta-amyloid accumulation in the brain of aged rats with spontaneous hypertension: Evaluation with dynamic contrast-enhanced magnetic resonance imaging [PDF]

, 2018
Chen, Wei, Gao, Fabao, Song, Li, Tao, Chuanyuan, Wang, Chunhua, Wang, Yu, Xu, Ziqian, Zhang, Ruzhi, Zheng, Jie   +8 more
core   +2 more sources

Concentration‐Based Analysis of Metal‐Induced Tau Fibrillar versus non‐fibrillar Aggregation: Implications for Neurotoxicity in Alzheimer's Disease

ChemistryOpen, EarlyView.
Tau protein aggregation and fibrillation have been examined in relationship to three metal ions in this study. The research was conducted to see the effects of Zn2+, Cu2+ and Fe3+ ions at different concentrations on tau′s conformation, cytotoxicity in SH‐SY5Y cells, and free thiol levels.
Mahzad Irandoust, Afrooz Anbaraki, Zahra Dindar, Atiyeh Ghasemi, Ali Akbar Saboury, Saeed Rayati, Arefeh Seyedarabi   +6 more
wiley   +1 more source

Exploration of small molecules as inhibitors of potential BACE1 protein to treat amyloid cerebrovascular disease by employing molecular modeling and simulation approaches. [PDF]

PLoS One
Wang Z, Li Z, Lin A, Zhang Q, Chen Y, Bie B, Feng J.   +6 more
europepmc   +1 more source