Results 241 to 250 of about 94,035 (378)

Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Microglia, the resident immune‐competent cells of the brain, become dysfunctional in Alzheimer's disease (AD), and their aberrant immune responses contribute to the accumulation of pathological proteins and neuronal injury. Genetic studies implicate microglia in the development of AD, prompting interest in developing immunomodulatory therapies
Madison K. Kuhn, Elizabeth A. Proctor
wiley   +1 more source

Polyoxometalates bind multiple targets involved in Alzheimer's disease. [PDF]

J Biol Inorg Chem
Ben Zaken K, Bouhnik R, Omer N, Bloch N, Samson AO.   +4 more
europepmc   +1 more source

Effect of the extract of Cimicifuga dahurica and its active compound on reducing formation of amyloid beta peptides in HeLa cells transfected with an amyloid precursor protein

, 2019
Ansun Park, Sang-Bin Lee, Yoon S. Chun, Young Ho Kim, Hyun Ok Yang   +4 more
openalex   +1 more source

Genetic and pharmacologic enhancement of SUMO2 conjugation prevents and reverses cognitive impairment and synaptotoxicity in a preclinical model of Alzheimer's disease. [PDF]

Alzheimers Dement
Fioriti L, Wijesekara N, Argyrousi EK, Matsuzaki S, Takamura H, Satoh K, Han K, Yamauchi H, Staniszewski A, Acquarone E, Orsini F, Martucci A, Katayama T, Arancio O, Fraser PE.   +14 more
europepmc   +1 more source

NIR‐Induced Photoswitching Hybrid DNA Nanoconstruct‐Based Drug Delivery System for Spatiotemporal Control of Stem Cell Fate

Small, EarlyView.
NIR‐mediated photo‐switching drug delivery system for the remote‐control differentiation of NSCs. Left: NIR‐mediated curcumin release is induced by NIR‐to‐UV photon upconversion in a photo‐controllable manner. Curcumin is bound in the minor groove of the synthesized DNA construct containing AAP photo‐switchers. Right: The rational design of several AAP
Thanapat Pongkulapa, Ji Hye Yum, Callan D. McLoughlin, Brandon Conklin, Tomotaka Kumagai, Li Ling Goldston, Hiroshi Sugiyama, Soyoung Park, Ki‐Bum Lee   +8 more
wiley   +1 more source

Reduced protein solubility - cause or consequence in amyloid disease? [PDF]

QRB Discov
Lindberg M, Hu J, Sparr E, Linse S.
europepmc   +1 more source

Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells.

, 1997
Tsuneo Yamazaki, Edward H. Koo, Dennis J. Selkoe   +2 more
openalex  

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Biofilm-Associated Amyloid Proteins Linked with the Progression of Neurodegenerative Diseases. [PDF]

Int J Mol Sci
Singh AA, Khan F, Song M.
europepmc   +1 more source

Role of membrane biophysics in Alzheimer\u27s–related cell pathways [PDF]

, 2015
Bungart, Brittani L, Lee, James C-M., Yang, Xiaoguang, Zhu, Donghui, Zhumadilov, Zhaxybay   +4 more
core   +1 more source