Results 251 to 260 of about 122,310 (350)

The therapeutic potential of beta-carotene against neuroinflammation and amyloid beta in SH-SY5Y cells. [PDF]

Sci Rep
Khan MI, Jeong ES, Tasreen G, Khan MZ, Shin JH, Kim JD.   +5 more
europepmc   +1 more source

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, Volume 13, Issue 3, 14 January 2026.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

Preexisting Genetic Background Primes the Responses of Human Neurons to Amyloid β. [PDF]

Int J Mol Sci
Soladogun AS, Zhang L.
europepmc   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source

Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich Cortex

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The extracellular space and diffusion around amyloid plaques are examined using shadow imaging and single‐particle tracking. Increased diffusivity is found near plaques, extracellular matrix alterations, and plaque core penetrability that varies with amyloid phenotype.
Juan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Evelyne Doudnikoff, Thierry Leste‐Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc, Urs Valentin Nägerl, Erwan Bezard   +11 more
wiley   +1 more source

The Importance of Being Imperfect: Structure and Function of Bacterial Amyloid

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Functional bacterial amyloids such as CsgA and FapC have been widely studied to understand the relationship between aggregation and function. The recently solved structure of FapC reveals a Greek‐key motif in which extensive hydrogen bonding and packing interactions formed by residues in conserved imperfect repeats stabilize a β‐solenoid core.
Samuel Peña‐Díaz, Yanting Jiang, Zhefei Zhang, Anders Daugberg, Pedro Ferreira, Marcos López Hernández, Chandrika Mittal, Maria Joao Ramos, Jan Skov Pedersen, Morten Kam Dahl Dueholm, Cao Qin, Huabing Wang, Daniel E. Otzen   +12 more
wiley   +1 more source

The amyloid-beta wave hypothesis of Alzheimer's disease. [PDF]

Front Cell Infect Microbiol
Miller SJ, Logan R, Zhang C, Hafler BP.
europepmc   +1 more source

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract BACKGROUND Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.
Anat Yaskolka Meir, Xingyan Wang, Shinya Tasaki, Vishal Sarsani, Aron S. Buchman, Steven E. Arnold, David A. Bennett, Vladislav A. Petyuk, Liming Liang, Ana W. Capuano, Zoe Arvanitakis   +10 more
wiley   +1 more source