FASEB BioAdvances, EarlyView.Deuterium, a heavy isotope of hydrogen, is universal in nature, but it disrupts the mitochondrial ATPase pumps. One mechanism that biological organisms may use to reduce deuterium levels in the mitochondria is to sequester deuterium bound to carbon atoms in a small set of organic molecules that have a unique configuration to support such trapping ...
Stephanie Seneff +2 more
wiley +1 more source
Identifying Alzheimer's disease genes in apolipoprotein E<sup>-/-</sup> mice brains with confirmed <i>Porphyromonas gingivalis</i> entry. [PDF]
J Alzheimers Dis RepSinghrao SK, Consoli C.
europepmc +1 more source
Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging
Aging Cell, EarlyView.Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom +26 more
wiley +1 more source
Clinical Importance of Amyloid Beta Implication in the Detection and Treatment of Alzheimer's Disease. [PDF]
Int J Mol SciPokrzyk J +4 more
europepmc +1 more source
NACP, the precursor protein of the non-amyloid beta/A4 protein (A beta) component of Alzheimer disease amyloid, binds A beta and stimulates A beta aggregation. [PDF]
, 1995 Makoto Yoshimoto +5 more
openalex +1 more source
Aging Cell, EarlyView.The role of mitochondrial translocator protein (TSPO) in hippocampal inflammation is age‐dependent, with TSPO deletion drastically exacerbating inflammation in aged mice, while dampening it in young mice. This TSPO–aging interaction was linked to NF‐kβ and interferon regulatory transcriptional networks. TSPO deletion exacerbated age‐dependent depletion
Kei Onn Lai +7 more
wiley +1 more source
Nrf2/Bach1 signaling axis: A promising multifaceted therapeutic strategy for Alzheimer's disease. [PDF]
NeurotherapeuticsSoni P +4 more
europepmc +1 more source
Aging Cell, EarlyView.Amyloid‐β (Aβ) oligomers affect VDAC1 electrophysiology and the physiological metabolic cross‐talk between cytosol and mitochondria. The use of a small, synthetic VDAC1‐antagonist peptide, derived from hexokinase, restores mitochondrial functionality, and respiration in cellular models of Alzheimer's disease. ABSTRACT Mitochondrial dysfunction has been
Fabrizio Cavallaro +10 more
wiley +1 more source
Reevaluating the role of amyloid <i>β</i>-peptides in Alzheimer's disease: from pathogenic agents to protective chelation mechanisms. [PDF]
Front NeurolCavaleri F.
europepmc +1 more source
A guide to selecting high-performing antibodies for amyloid-beta precursor protein for use in Western Blot, immunoprecipitation and immunofluorescence [PDF]
Riham Ayoubi +4 more
openalex +1 more source