Results 261 to 270 of about 94,035 (378)

Reducing HuD Levels Alleviates Alzheimer's Disease Pathology in 5xFAD Mice

Aging Cell, EarlyView.
The effect of ablating expression of the RNA‐binding protein HuD (ELAVL4) in neurons was evaluated in the Alzheimer's mouse model 5xFAD. We found that conditional removal of HuD resulted in diminished Aβ plaque formation and reduced AD‐associated hyperactivity in 5xFAD/HuDcKO mice relative to 5xFAD mice.
Eunbyul Ji, Apala Pal, Quia C. Claybourne, Marc Michel, Rachel Munk, Ross A. McDevitt, Chang‐Yi Cui, Myriam Gorospe   +7 more
wiley   +1 more source

CRISPR/Cas9-Based therapeutics as a promising strategy for management of Alzheimer's disease: progress and prospects. [PDF]

Front Cell Neurosci
Khan MS, Qureshi N, Khan R, Son YO, Maqbool T.   +4 more
europepmc   +1 more source

The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey [PDF]

, 2017
Bateman, Randy J, et al,
core   +2 more sources

Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia‐Dependent Plaque Response in Aged Mice

Aging Cell, EarlyView.
This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez, Cristina Nuñez‐Diaz, Kelly Do Huynh, Marie Minh Thu Nguyen, Celia Da Cunha, Francisco J. Cantero‐Molina, Cynthia Campos‐Moreno, Stefania Zimbone, Francesco Bellia, Maria Laura Giuffrida, Laura Trujillo‐Estrada, Juan Antonio Garcia‐Leon, Miriam Bettinetti‐Luque, Nazaret Gamez, Catalina Valdes, Rodrigo Morales, Stefania Forner, Alessandra C. Martini, Antonia Gutierrez, Frank M. LaFerla, David Baglietto‐Vargas   +20 more
wiley   +1 more source

Advance in identified targets of berberine. [PDF]

Front Pharmacol
Sun P, Wang Z, Ma Y, Liu Y, Xue Y, Li Y, Gao X, Wang Y, Chu M.   +8 more
europepmc   +1 more source

SGLT2 Inhibition by Enavogliflozin Significantly Reduces Aβ Pathology and Restores Cognitive Function via Upregulation of Microglial AMPK Signaling in 5XFAD Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
SGLT2 inhibition with Enavogliflozin significantly improves cognitive function and reduces Aβ pathology in the 5XFAD mouse model of Alzheimer's disease. Through AMPK activation, Enavogliflozin enhances microglial mitochondrial function and Aβ phagocytosis while reducing neuroinflammation.
Jihui Han, Jaehoon Song, Eun Sun Jung, Ji Won Choi, Hye Young Ji, Inhee Mook‐Jung   +5 more
wiley   +1 more source

Bibliometric analysis and description of research trends on nutritional management in Alzheimer's disease patients (1988-2024). [PDF]

Front Nutr
Meng C, Li B, Wang Z, Peng Q.
europepmc   +1 more source

Aβ34 is a BACE1-derived degradation intermediate associated with amyloid clearance and Alzheimer’s disease progression [PDF]

, 2019
Bateman, Randall J.
core   +1 more source

The molecular landscape of AL amyloidosis

British Journal of Haematology, EarlyView.
Within the bone marrow, the clonal plasma cell population exhibits an abnormal expression of non‐coding RNAs, which, in turn, upregulates anti‐apoptotic genes (BCL2, MCL1, BCL2L1), leading to an anti‐apoptotic effect that promotes plasma cell survival.
Tal Zvida‐Bloch, Eli Muchtar, Angela Dispenzieri, Ofer Shpilberg, Oshrat Hershkovitz‐Rokah   +4 more
wiley   +1 more source

Gastrointestinal Dysfunction and Low-Grade Inflammation Associate With Enteric Neuronal Amyloid-β in a Model for Amyloid Pathology. [PDF]

Neurogastroenterol Motil
Tasnády KR, Jehoul R, de Ravé MG, Gijbels MJ, Brône B, Dewachter I, Melotte V, Boesmans W.   +7 more
europepmc   +1 more source