Results 61 to 70 of about 20,912 (233)

Hydrogen sulfide inhibits A2A adenosine receptor agonist induced β-amyloid production in SH-SY5Y neuroblastoma cells via a cAMP dependent pathway. [PDF]

PLoS ONE, 2014
Alzheimer's disease (AD) is the leading cause of senile dementia in today's society. Its debilitating symptoms are manifested by disturbances in many important brain functions, which are influenced by adenosine.
Bhushan Vijay Nagpure, Jin-Song Bian
doaj   +1 more source

Regulation of autophagy‐mediated pathways by diet, physical activity, and sleep in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath, Zoe Mputhia, Christopher Dougherty, Bushra Kaleelur Rahuman, W. M. A. D. Binosha Fernando, Belinda Brown, Samantha L. Gardener, Stephanie R. Rainey‐Smith, Ralph Martins, Prashant Bharadwaj   +9 more
wiley   +1 more source

Contribution of the Endosomal-Lysosomal and Proteasomal Systems in Amyloid-β Precursor Protein Derived Fragments Processing

Frontiers in Cellular Neuroscience, 2018
Aβ peptides, the major components of Alzheimer’s disease (AD) amyloid deposits, are released following sequential cleavages by secretases of its precursor named the amyloid precursor protein (APP).
Caroline Evrard, Pascal Kienlen-Campard, Mathilde Coevoet, Rémi Opsomer, Bernadette Tasiaux, Patricia Melnyk, Jean-Noël Octave, Luc Buée, Nicolas Sergeant, Valérie Vingtdeux   +9 more
doaj   +1 more source

Mutations Alter Conformations and Dynamics of APP‐TMDs: An RDC Analysis

ChemistryEurope, Volume 4, Issue 2, February 2026.
How γ‐secretase selects its substrates has been an enigma because of the lack of a consensus sequence. Using residual dipolar couplings, we analyzed the conformations of one substrate and two mutants. Using snapshots of a molecular dynamics trajectory, we analyzed how well structures matched the measured RDC values.
Franziska Krause, Celine Moser, David Elsing, Mara Silber, Fabian Hoffmann, Yannik Woordes, Burkhard Luy, Claudia Muhle‐Goll   +7 more
wiley   +1 more source

Endosomal Sorting of Amyloid Precursor Protein‐P‐Selectin Chimeras Influences Secretase Processing [PDF]

Traffic, 2001
Amyloid β protein, the major component of the senile plaques in Alzheimer's disease, is generated by secretory and endocytic processing of amyloid precursor protein. Internalized amyloid precursor protein either recycles to the plasma membrane, where α‐secretase resides, or moves to acidic compartment(s) for β‐secretase exposure.
B L, Daugherty, S A, Green
openaire   +2 more sources

β‐Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing NLRP3 Inflammasome Assembly

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu, Wanying Xu, Jinxin He, Jiahui Qian, Hui Wang, Changyu Li, Xiaojie Zhou   +6 more
wiley   +1 more source

Role of P2X7 and P2Y2 receptors on α-secretase-dependent APP processing: Control of amyloid plaques formation “in vivo” by P2X7 receptor

Computational and Structural Biotechnology Journal, 2015
Amyloid precursor protein (APP) is expressed in a large variety of neural and non-neural cells. The balance between non-pathogenic and pathologic forms of APP processing, mediated by α-secretase and β-secretase respectively, remains a crucial step to ...
M. Teresa Miras-Portugal, Juan I. Diaz-Hernandez, Rosa Gomez-Villafuertes, Miguel Diaz-Hernandez, Antonio R. Artalejo, Javier Gualix   +5 more
doaj   +1 more source

High resolution imaging study of interactions between the 37 kDa/67 kDa laminin receptor and APP, beta-secretase and gamma-secretase in Alzheimer's disease.

PLoS ONE, 2014
Alzheimer's disease (AD) is the most prevalent form of dementia affecting the elderly. Neurodegeneration is caused by the amyloid beta (Aβ) peptide which is generated from the sequential proteolytic cleavage of the Amyloid Precursor Protein (APP) by the ...
Katarina Jovanovic, Ben Loos, Bianca Da Costa Dias, Clement Penny, Stefan F T Weiss   +4 more
doaj   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury [PDF]

Brain Research, 2014
Amyloid-β (Aβ) is produced through the enzymatic cleavage of amyloid precursor protein (APP) by β (Bace1) and γ-secretases. The accumulation and aggregation of Aβ as amyloid plaques is the hallmark pathology of Alzheimer׳s disease and has been found in other neurological disorders, such as traumatic brain injury and multiple sclerosis.
Ahdeah, Pajoohesh-Ganji, Mark P, Burns, Sonali, Pal-Ghosh, Gauri, Tadvalkar, Nicole G, Hokenbury, Mary Ann, Stepp, Alan I, Faden   +6 more
openaire   +2 more sources