Results 51 to 60 of about 18,838 (278)
The role of disorder in RNA binding affinity and specificity [PDF]
Open Biology, 2020 Most RNA-binding modules are small and bind few nucleotides. RNA-binding proteins typically attain the physiological specificity and affinity for their RNA targets by combining several RNA-binding modules.
Diana S. M. Ottoz, Luke E. Berchowitz
doaj +1 more source
An Investigation of the Efficacy of Curcumin for Treatment of Alzheimer\u27s Disease [PDF]
, 2016 Curcumin is the primary curcuminoid found in the rhizome of the turmeric plant (Curcuma longa), responsible for the spice’s distinctive yellow color. Research conducted within the past two decades suggests that the compound may be an effective treatment ...
Patel, Parantap
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Failure of Aβ(1-40) amyloid fibrils under tensile loading [PDF]
, 2010 Amyloid fibrils and plaques are detected in the brain tissue of patients affected by Alzheimer’s disease, but have also been found as part of normal physiological processes such as bacterial adhesion.
Buehler, Markus J, Paparcone, Raffaella
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International Journal of Surgery, 2008 Amyloidosis refers to a variety of conditions in which amyloid proteins are abnormally deposited in organs and/or tissues. Amyloidosis is a rare occurrence in thyroid gland.A systematic review of the published data on amyloid goiter was carried out by searching Medline and other online databases (such as Scopus and Endnote) for the period from 1951 to ...
VILLA F +4 more
openaire +4 more sources
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Mapping the Beta-Sheet Structure of the Yeast Prion Sup35 through Creation of Targeted Mutant Forms [PDF]
, 2013 Proteins with an aggregated form rich in beta-sheet structure are known as amyloids, of which a subset are infectious. These infectious proteins are known as prions and cause diseases including bovine spongiform encephalopathy (“Mad Cow” disease ...
Davis, Emily K. +2 more
core +1 more source
Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs [PDF]
, 2016 Altres ajuts: MARATOTV3/2013/3930In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules.
Abasolo, Ibane +15 more
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FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
A structural rationale for reversible vs irreversible amyloid fibril formation from a single protein
Nature CommunicationsReversible and irreversible amyloids are two diverging cases of protein (mis)folding associated with the cross-β motif in the protein folding and aggregation energy landscape.
Lukas Frey +13 more
doaj +1 more source
“What Doesn’t Kill You Makes You Stronger”: Future Applications of Amyloid Aggregates in Biomedicine
Molecules, 2020 Amyloid proteins are linked to the pathogenesis of several diseases including Alzheimer’s disease, but at the same time a range of functional amyloids are physiologically important in humans.
Sherin Abdelrahman +5 more
doaj +1 more source