Results 131 to 140 of about 11,917 (183)

Anandamide receptors

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
Anandamide (N -arachidonoyl-ethanolamine, AEA) was the first endogenous ligand of cannabinoid receptors to be discovered. Yet, since early studies, AEA appeared to exhibit also some effects that were not mediated by cannabinoid CB(1) or CB(2) receptors.
Di Marzo V, De Petrocellis L, Fezza F, Ligresti A, Bisogno T   +4 more
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Anandamide transport

Pharmacology & Therapeutics, 2004
N-Arachidonylethanolamine (anandamide) is an endogenous agonist of the cannabinoid CB1 and CB2 receptors and displays many of the same receptor-mediated physiological effects as delta9-tetrahydrocannabinol (delta9-THC), the active component of marijuana. As with any neurotransmitter, there must be tight control of anandamide receptor-mediated signaling
Matthew J, McFarland, Eric L, Barker
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Anandamide: an update

Fundamental & Clinical Pharmacology, 2006
AbstractEndocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2‐arachidonoylglycerol.
K, Smita, V, Sushil Kumar, J S, Premendran   +2 more
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Anandamide and vanilloid TRPV1 receptors [PDF]

British Journal of Pharmacology, 2003
A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as
exaly   +3 more sources

Cardiovascular pharmacology of anandamide

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular
Edward D, Högestätt, P M, Zygmunt
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Oxidative metabolism of anandamide

Prostaglandins & Other Lipid Mediators, 2000
In addition to the well studied hydrolytic metabolism of anandamide, a number of oxidative processes are also possible. Several routes somewhat analogous to the metabolism of free arachidonic acid have been reported. These involve mediation by various lipoxygenases and COX-2 and lead to ethanolamide analogs of the prostaglandins and HETES.
S H, Burstein, R G, Rossetti, B, Yagen, R B, Zurier   +3 more
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Biphasic Effects of Anandamide

Pharmacology Biochemistry and Behavior, 1998
Effects of the endogenous cannabimimetic anandamide were assessed over a wide dose range in a series of physiological and behavioral assays. These included the tetrad of tests in mice commonly used to assess cannabinoid-induced effects (motor activity, ring catalepsy, hypothermia, and analgesia tests), as well as a model for agonistic behavior on ...
E, Sulcova, R, Mechoulam, E, Fride
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Anandamide: some like it hot

Trends in Pharmacological Sciences, 2001
Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
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