Results 1 to 10 of about 10,975 (239)

Interleukin-33 Amplifies Human Mast Cell Activities Induced by Complement Anaphylatoxins

Frontiers in Immunology, 2021
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically ...
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus   +8 more
doaj   +2 more sources

Complement activation during cardiopulmonary bypass and association with clinical outcomes

eJHaem, 2022
In this prospective, single‐centre observational study of 30 patients undergoing cardiopulmonary bypass (CPB), the effect of unfractionated heparin (UFH), CPB surgery and protamine sulphate on complement and on post‐operative blood loss were assessed ...
Rengina Kefalogianni, Farah Kamani, Mihaela Gaspar, TC Aw, Jackie Donovan, Mike Laffan, Matthew C. Pickering, Deepa J. Arachchillage   +7 more
doaj   +1 more source

Anaphylatoxin Complement 5a in Pfizer BNT162b2-Induced Immediate-Type Vaccine Hypersensitivity Reactions

Vaccines, 2023
The underlying immunological mechanisms of immediate-type hypersensitivity reactions (HSR) to COVID-19 vaccines are poorly understood. We investigate the mechanisms of immediate-type hypersensitivity reactions to the Pfizer BNT162b2 vaccine and the ...
Xin Rong Lim, Grace Yin Lai Chan, Justina Wei Lynn Tan, Carol Yee Leng Ng, Choon Guan Chua, Guat Bee Tan, Stephrene Seok Wei Chan, Kiat Hoe Ong, Ying Zhi Tan, Sarah Hui Zhen Tan, Claire Min Li Teo, Samuel Shang Ming Lee, Bernard Yu Hor Thong, Bernard Pui Lam Leung   +13 more
doaj   +1 more source

A porcine model of hemodialyzer reactions: roles of complement activation and rinsing back of extracorporeal blood

Renal Failure, 2021
Hemodialysis reactions (HDRs) resemble complement-activation-related pseudoallergy (CARPA) to certain i.v. drugs, for which pigs provide a sensitive model. On this basis, to better understand the mechanism of human HDRs, we subjected pigs to hemodialysis
Ákos Pethő, Dorothea Piecha, Tamás Mészáros, Rudolf Urbanics, Christoph Moore, Bernard Canaud, László Rosivall, Tom Eirik Mollnes, Sonja Steppan, Gábor Szénási, János Szebeni, László Dézsi   +11 more
doaj   +1 more source

Interleukin-1β and anaphylatoxins exert a synergistic effect on NGF expression by astrocytes

Journal of Neuroinflammation, 2006
C3a and C5a anaphylatoxins are proinflammatory polypeptides released during complement activation. They exert their biological activities through interaction with two G protein-coupled receptors named C3aR and C5aR, respectively.
Patte Christine, Schouft Marie-therese, Chan Philippe, Benard Magalie, Chatagner Alexandra, Ischenko Alexander, Jauneau Anne-christine, Vaudry Hubert, Fontaine Marc   +8 more
doaj   +1 more source

Complement System: Promoter or Suppressor of Cancer Progression?

Antibodies, 2020
Constituent of innate immunity, complement is present in the tumor microenvironment. The functions of complement include clearance of pathogens and maintenance of homeostasis, and as such could contribute to an anti-tumoral role in the context of certain
Margot Revel, Marie V. Daugan, Catherine Sautés-Fridman, Wolf H. Fridman, Lubka T. Roumenina   +4 more
doaj   +1 more source

Anaphylatoxin and Anaphylaxis: I. Trypanosome Anaphylatoxin [PDF]

Journal of Infectious Diseases, 1917
FOREWORD METHODS EMPLOYED AttAPHYLATOXIN-PRODUCTION WITH : SURRA TRYPANOSOME (T. EVAN SI) CADERAS TRYPANOSOME (t. EQUINUM) DOURINE TRYPANOSOME (T. EQUIPERDUM) TRYPANOSOMA LEWISI SERIAL PRODUCTION NAGANA TRYPANOSOME (t. BRUCEl) GUINEA-PIG SERUM ; SERIAL PRODUCTION J TOXIC WAVE.
F. G. Novy, P. H. DeKruif, R. L. Novy
openaire   +1 more source

Role of Complement and Histones in Sepsis

Frontiers in Medicine, 2020
The wide use of the mouse model of polymicrobial sepsis has provided important evidence for events occurring in infectious sepsis involving septic mice and septic humans.
Firas S. Zetoune, Peter A. Ward
doaj   +1 more source

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C V Portaro, Solange M T Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W van den Berg, Denise V Tambourgi   +7 more
doaj   +1 more source

Carboxypeptidase B blocks ex vivo activation of the anaphylatoxin-neutrophil extracellular trap axis in neutrophils from COVID-19 patients

Critical Care, 2021
Background Thrombosis and coagulopathy are highly prevalent in critically ill patients with COVID-19 and increase the risk of death. Immunothrombosis has recently been demonstrated to contribute to the thrombotic events in COVID-19 patients with ...
Yue Zhang, Kai Han, Chunjing Du, Rui Li, Jingyuan Liu, Hui Zeng, Liuluan Zhu, Ang Li   +7 more
doaj   +1 more source