Results 141 to 150 of about 7,941 (204)

Anaphylatoxins

Immunologic Research, 2007
Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation
Jos A G Van Strijp, Pieter-Jan Haas
exaly   +3 more sources

The anaphylatoxins

1997
Abstract As well as opsonization and cytolysis by C3 degradation products and the membrane attack complex, the activation of the complement system results in the generation of the proinflammatory polypeptides C3a, C4a, C5a, and C5adesArg, which are collectively described as anaphylatoxins or anaphylatoxic peptides (AT peptides).
Joerg Koehl, Kohl Jörg
exaly   +2 more sources

Anaphylatoxins in organ transplantation

Seminars in Immunology, 2013
C3a and C5a (also called anaphylatoxins) are inflammatory peptides generated during complement activation. They do not only play important roles in innate immunity through the initiation and regulation of inflammatory responses, but also significantly influence adaptive immune responses.
Li, Ke, Zhou, Wuding
openaire   +4 more sources

Anaphylatoxins: C3a and C5a

Advances in Immunology, 1978
Publisher Summary This chapter discusses the structural and functional characterization of anaphylatoxins, spasmogenic substances released during complement activation. These low molecular weight peptide fragments of C3 and C5 elicit a variety of cellular responses, which implies that they play a significant role in inflammation and acute allergic ...
T E, Hugli, H J, Müller-Eberhard
openaire   +3 more sources

Structure and Function of the Anaphylatoxins

Springer Seminars in Immunopathology, 1984
Chemical and physical characterization of the anaphylatoxin molecules have provided a reasonably clear description of the architecture of these bioactive proteins. The primary structures of C3a, C4a, and C5a from man and from a number of animal species have been elucidated, and it is apparent that the three anaphylatoxins are genetically related.
T. Hugli
openaire   +3 more sources

Biochemistry and Biology of Anaphylatoxins

Complement, 2017
The molecular architecture of anaphylatoxins has been explored on several levels. Primary, secondary and tertiary structural parameters that dictate function of the C3a, C4a and C5a molecules are being elucidated with the aid of comparative sequence analyses, physical measurements and organic syntheses.
T. Hugli
openaire   +3 more sources

Anaphylatoxins and their corresponding receptors as potential drivers in cartilage calcification during osteoarthritis progression

Osteoarthritis and Cartilage
OBJECTIVE The complement cascade as major fluid phase innate immune system is activated during progression of osteoarthritis (OA). Generated anaphylatoxins and the corresponding receptors C3aR and C5aR1 are associated with the calcification of blood ...
Gundula Schulze-Tanzil, Jana Riegger, Markus Huber-Lang   +2 more
exaly   +2 more sources

Anaphylatoxins Enhance Recruitment of Nonclassical Monocytes via Chemokines Produced by Pleural Mesothelial Cells in Tuberculous Pleural Effusion

American Journal of Respiratory Cell and Molecular Biology, 2019
&NA; In the present study, we sought to elucidate the mechanisms by which monocytes migrate into the pleural space in the presence of anaphylatoxins in tuberculous pleural effusion (TPE).
Chengping Hu, Juntao Feng, Xiaozhao Li   +2 more
exaly   +2 more sources

Complement anaphylatoxins as immune regulators in cancer

Cancer Medicine, 2014
The role of the complement system in innate immunity is well characterized. However, a recent body of research implicates the complement anaphylatoxins C3a and C5a as insidious propagators of tumor growth and progression.
Orin Bloch
exaly   +2 more sources

The new face of anaphylatoxins in immune regulation

Immunobiology, 2012
Wuding Zhou
exaly   +2 more sources