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The new face of anaphylatoxins in immune regulation
Immunobiology, 2012 Anaphylatoxins are a group of small peptides (i.e. C3a, C4a and C5a) generated by complement activation and play important roles in innate immunity through the initiation and regulation of inflammatory responses.
Wuding Zhou
exaly +2 more sources
Complement anaphylatoxins as immune regulators in cancer [PDF]
Cancer Medicine, 2014 The role of the complement system in innate immunity is well characterized. However, a recent body of research implicates the complement anaphylatoxins C3a and C5a as insidious propagators of tumor growth and progression.
Orin G Bloch +2 more
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Effects of the anaphylatoxins on circulation
Immunopharmacology, 1987Anaphylatoxins (e.g. activation fragments C3a, C4a and C5a) are bioactive cleavage products released from plasma components C3, C4 and C5, respectively, during complement activation. The biologic role of anaphylatoxins is generally characterized as pro-inflammatory, since these factors recruit numerous tissue mediators of the host defense system.
François Marceau +2 more
exaly +3 more sources
Immunologic Research, 2007
Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation
Jos A. G. Van Strijp, Pieter-Jan Haas
exaly +3 more sources
Activation of the complement system plays a crucial role in the pathogenesis of infection and inflammation. Especially the complement activation products C3a and C5a, known as the anaphylatoxins, are potent proinflammatory mediators. In addition to their evident role in innate immunity, it is clear that the anaphylatoxins also play a role in regulation
Jos A. G. Van Strijp, Pieter-Jan Haas
exaly +3 more sources
Staphylococcal SSL5 inhibits leukocyte activation by chemokines and anaphylatoxins
Blood, 2009 Staphylococcus aureus secretes several virulence factors modulating immune responses. Staphylococcal superantigen-like (SSL) proteins are a family of 14 exotoxins with homology to superantigens, but with generally unknown function.
Jos A. G. Van Strijp +2 more
exaly +2 more sources
Open Journal of Veterinary Medicine, 2012 This review updates original data describing the experiments showing the complement origin of anaphylatoxins unexplainable submerged under the surface of the articles related to the subject.
Wilmar Dias da Silva
exaly +1 more source
1997
Abstract As well as opsonization and cytolysis by C3 degradation products and the membrane attack complex, the activation of the complement system results in the generation of the proinflammatory polypeptides C3a, C4a, C5a, and C5adesArg, which are collectively described as anaphylatoxins or anaphylatoxic peptides (AT peptides).
Jörg Köhl
exaly +2 more sources
Abstract As well as opsonization and cytolysis by C3 degradation products and the membrane attack complex, the activation of the complement system results in the generation of the proinflammatory polypeptides C3a, C4a, C5a, and C5adesArg, which are collectively described as anaphylatoxins or anaphylatoxic peptides (AT peptides).
Jörg Köhl
exaly +2 more sources
Anaphylatoxins in dilated cardiomyopathy
Journal of Internal Medicine, 1993Abstract. Objects. The aim of the study was to investigate the possible relationship between activation of complement system and thromboembolic complications in dilated cardiomyopathy (DCMP).Methods. The plasma C3a and C5a concentrations were determined by radioimmunoassay measurement (Amersham International, UK) in 23 patients with DCMP, 9 with ...
M, Samsonov +5 more
openaire +2 more sources
Structure and Function of the Anaphylatoxins
Springer Seminars in Immunopathology, 1984Chemical and physical characterization of the anaphylatoxin molecules have provided a reasonably clear description of the architecture of these bioactive proteins. The primary structures of C3a, C4a, and C5a from man and from a number of animal species have been elucidated, and it is apparent that the three anaphylatoxins are genetically related.
openaire +2 more sources