Results 11 to 20 of about 10,975 (239)

Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion.

PLoS Neglected Tropical Diseases, 2021
The complement system is activated in tuberculous pleural effusion (TPE), with increased levels of the anaphylatoxins stimulating pleural mesothelial cells (PMCs) to secrete chemokines, which recruit nonclassical monocytes to the pleural cavity.
Shuanglinzi Deng, Xinyue Hu, Lisha Luo, Wei Tang, Yuanyuan Jiang, Feifei Yin, Chengping Hu, Juntao Feng, Xiaozhao Li   +8 more
doaj   +2 more sources

Anaphylatoxins spark the flame in early autoimmunity

Frontiers in Immunology, 2022
The complement system (CS) is an ancient and highly conserved part of the innate immune system with important functions in immune defense. The multiple fragments bind to specific receptors on innate and adaptive immune cells, the activation of which ...
Jovan Schanzenbacher, Jörg Köhl, Jörg Köhl, Christian M. Karsten   +3 more
doaj   +2 more sources

Complement system part I - molecular mechanisms of activation and regulation [PDF]

Frontiers in Immunology, 2015
Complement is a complex innate immune surveillance system, playing a key role in defense against pathogens and in host homeostasis. The complement system is initiated by conformational changes in recognition molecular complexes upon sensing danger ...
Nicolas eMerle, Sarah Elizabeth Church, Veronique eFremeaux-Bacchi, Lubka T. Roumenina   +3 more
doaj   +4 more sources

Requirements for membrane attack complex formation and anaphylatoxins binding to collagen-activated platelets. [PDF]

PLoS ONE, 2011
The activation of complement during platelet activation is incompletely understood.We sought to explore the formation of C5b-9 and anaphylatoxins binding to collagen-activated platelets.C5b-9, anaphylatoxins C3a, C4a and C5a, and anaphylatoxin receptors ...
Catherine Martel, Sylvie Cointe, Pascal Maurice, Saïd Matar, Marta Ghitescu, Pierre Théroux, Arnaud Bonnefoy   +6 more
doaj   +2 more sources

Complement Anaphylatoxins and Inflammatory Cytokines as Prognostic Markers for COVID-19 Severity and In-Hospital Mortality

Frontiers in Immunology, 2021
COVID-19 severity due to innate immunity dysregulation accounts for prolonged hospitalization, critical complications, and mortality. Severe SARS-CoV-2 infections involve the complement pathway activation for cytokine storm development. Nevertheless, the
Bandar Alosaimi, Bandar Alosaimi, Ayman Mubarak, Maaweya E. Hamed, Abdullah Z. Almutairi, Ahmed A. Alrashed, Abdullah AlJuryyan, Mushira Enani, Faris Q. Alenzi, Wael Alturaiki   +9 more
doaj   +2 more sources

Anaphylatoxins Activate Ca2+, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium

Frontiers in Immunology, 2017
PurposeThe retinal pigment epithelium (RPE) is a main target for complement activation in age-related macular degeneration (AMD). The anaphylatoxins C3a and C5a have been thought to mostly play a role as chemoattractants for macrophages and immune cells;
Catharina Busch, Catharina Busch, Balasubramaniam Annamalai, Khava Abdusalamova, Nadine Reichhart, Christian Huber, Christian Huber, Yuchen Lin, Emeraldo A. H. Jo, Peter F. Zipfel, Christine Skerka, Gerhild Wildner, Maria Diedrichs-Möhring, Bärbel Rohrer, Bärbel Rohrer, Olaf Strauß   +15 more
doaj   +2 more sources

Targeting C3a and C5a Signaling—A Game Changer for Cancer Therapy? [PDF]

Biology
Emerging evidence reveals a significant shift in understanding the complement system’s role in cancer, where activation of a complement within the tumor microenvironment (TME) fuels tumor growth and metastasis instead of suppressing it.
Hunter Hudgins, Valeria Molina, Stanley Wiernicki, Kenneth Okwuegbe, Xiaodong Feng, Hongbin Wang   +5 more
doaj   +2 more sources

Africanized honeybee venom (Apis mellifera) promotes human complement activation split products storm [PDF]

Frontiers in Immunology
IntroductionComplement activation split products are signatures of many immunopathological disorders. Among the laboratory findings observed in these diseases, a reduction in the level of circulating intact complement components can be mentioned, and ...
Felipe Silva de França, Felipe Silva de França, Ricardo de Oliveira Orsi, Dayanne Carla Fernandes, Dayanne Carla Fernandes, Thyago Bispo Leonel, Thyago Bispo Leonel, Denise V. Tambourgi, Denise V. Tambourgi   +8 more
doaj   +2 more sources

VI. —Anaphylaxis and anaphylatoxins [PDF]

Philosophical Transactions of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1923
In the study of the phenomena of anaphylaxis there are certain points on which some measure of agreement seems to have been attained. In the case of anaphylaxis to soluble proteins, with which alone we are directly concerned in this paper, the majority of investigators probably accept the view that the condition is due to the formation of an antibody ...
H. Dale, C. Kellaway
openaire   +2 more sources

Micrurus snake venoms activate human complement system and generate anaphylatoxins

BMC Immunology, 2012
Background The genus Micrurus, coral snakes (Serpentes, Elapidae), comprises more than 120 species and subspecies distributed from the south United States to the south of South America. Micrurus snake bites can cause death by muscle paralysis and further
Tanaka Gabriela D, Pidde-Queiroz Giselle, Furtado Maria de Fátima D, van den Berg Carmen, Tambourgi Denise V   +4 more
doaj   +2 more sources