Complement anaphylatoxins: Potential therapeutic target for diabetic kidney disease. [PDF]
Diabet MedDiabetic kidney disease (DKD) is the most common cause of kidney failure, characterized by chronic inflammation and fibrosis. The complement system is increasingly implicated in the development and progression of diabetic nephropathy.
Ma J, Yiu WH, Tang SCW.
europepmc +2 more sources
Modulation of Neutrophil Activity by Soluble Complement Cleavage Products—An In-Depth Analysis
Cells, 2022 The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors.
Lisa Wohlgemuth +14 more
doaj +1 more source
Biomedicines, 2023 The liver has a huge impact on the functioning of our body and the preservation of homeostasis. It is exposed to many serious diseases, which may lead to the chronic failure of this organ, which is becoming a global health problem today.
Marta Budkowska +11 more
doaj +1 more source
Biomedicines, 2021 Activation of the complement system is important for efficient clearance of a wide variety of pathogens via opsonophagocytosis, or by direct lysis via complement-dependent cytotoxicity (CDC).
Carolin Schmidt +8 more
doaj +1 more source
Deletion of the Complement C5a Receptor Alleviates the Severity of Acute Pneumococcal Otitis Media following Influenza A Virus Infection in Mice [PDF]
, 2014 There is considerable evidence that influenza A virus (IAV) promotes adherence, colonization, and superinfection by S. pneumoniae (Spn) and contributes to the pathogenesis of otitis media (OM).
Bowman, Andrew S. +8 more
core +9 more sources
Role of the Complement System in the Modulation of T-Cell Responses in Chronic Chagas Disease
Frontiers in Cellular and Infection Microbiology, 2022 Chagas disease, caused by the intracellular pathogen Trypanosoma cruzi, is the parasitic disease with the greatest impact in Latin America and the most common cause of infectious myocarditis in the world.
María Belén Caputo +6 more
doaj +1 more source
ColdZyme Maintains Integrity in SARS-CoV-2-Infected Airway Epithelia
mBio, 2021 SARS-CoV-2 infection causing the COVID-19 pandemic calls for immediate interventions to avoid viral transmission, disease progression, and subsequent excessive inflammation and tissue destruction. Primary normal human bronchial epithelial cells are among
W. Posch +7 more
doaj +1 more source
An Anti-C1s Monoclonal, TNT003, Inhibits Complement Activation Induced by Antibodies Against HLA. [PDF]
, 2015 Antibody-mediated rejection (AMR) of solid organ transplants (SOT) is characterized by damage triggered by donor-specific antibodies (DSA) binding donor Class I and II HLA (HLA-I and HLA-II) expressed on endothelial cells.
Fishbein, MC +7 more
core +1 more source
Complement System Part II: Role in Immunity [PDF]
, 2015 International audienceThe complement system has been considered for a long time as a simple lytic cascade, aimed to kill bacteria infecting the host organism.
Fremeaux-Bacchi, Veronique +4 more
core +13 more sources
Loss of very-long O-antigen chains optimizes capsule-mediated immune evasion by Salmonella enterica serovar Typhi. [PDF]
, 2013 UnlabelledExpression of capsular polysaccharides is a variable trait often associated with more-virulent forms of a bacterial species. For example, typhoid fever is caused by the capsulated Salmonella enterica serovar Typhi, while nontyphoidal Salmonella
Bäumler, Andreas J +5 more
core +1 more source