Results 1 to 10 of about 230,623 (311)

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

Cell Death and Disease, 2021
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio, Antimo Migliaccio, Anna Tesei, Gabriella Castoria   +12 more
doaj   +1 more source

A Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes

Technology in Cancer Research & Treatment, 2021
Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is ...
Taobo Hu, Guiyang Zhao, Yiqiang Liu, Mengping Long   +3 more
doaj   +1 more source

Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. [PDF]

PLoS ONE, 2013
The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not
Yi-Chien Yang, Hung-Chun Fu, Ching-Yuan Wu, Kuo-Ting Wei, Ko-En Huang, Hong-Yo Kang   +5 more
doaj   +1 more source

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. [PDF]

PLoS ONE, 2014
Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the ...
Pierluigi Gasparini, Matteo Fassan, Luciano Cascione, Gulnur Guler, Serdar Balci, Cigdem Irkkan, Carolyn Paisie, Francesca Lovat, Carl Morrison, Jianying Zhang, Aldo Scarpa, Carlo M Croce, Charles L Shapiro, Kay Huebner   +13 more
doaj   +1 more source

Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence

Cell Death Discovery, 2023
Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor.
Marzia Di Donato, Antimo Moretti, Carmela Sorrentino, Giuseppe Toro, Giulia Gentile, Giovanni Iolascon, Gabriella Castoria, Antimo Migliaccio   +7 more
doaj   +1 more source

Does changing androgen receptor status during prostate cancer development impact upon cholesterol homeostasis? [PDF]

PLoS ONE, 2013
Recent evidence associates prostate cancer with high cholesterol levels, with cholesterol being an important raw material for cell-growth. Within the cell, cholesterol homeostasis is maintained by two master transcription factors: sterol-regulatory ...
James Robert Krycer, Andrew John Brown
doaj   +1 more source

IMMUNOHISTOCHEMICAL EXPRESSION OF ANDROGEN RECEPTOR IN TRIPLE NEGATIVE BREAST CARCINOMA AT ARMED FORCES INSTITUTE OF PATHOLOGY, RAWALPINDI

Pakistan Armed Forces Medical Journal, 2021
Objective: To determine the frequency of immunohistochemical expression of androgen receptor in triple negative breast carcinoma. Study Design: Cross sectional study.
Amna Ameer, Farhan Akhtar, Hafeez Ud Din, Rabia Ahmad   +3 more
doaj   +3 more sources

WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics [PDF]

, 2009
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures.
A de la Taille, A Glinka, A van Bokhoven, AA George, AP Verhagen, AS Waller, AT Collins, AT Collins, AT Collins, B Hoang, B Mao, BA Reynolds, C Lo Celso, C Wissmann, CC Carson 3rd, CI Truica, CL Hall, CL Hall, D Beier, D Bonnet, D Masiello, D Mizrak, DA Lawson, David M Prowse, DK Singla, DL Hudson, DL Hudson, DP Petrylak, DR Chesire, EM Hurt, G Dontu, G Gu, G Shaw, G Shaw, GD Richardson, GJ van Leenders, GL Shaw, GN Thalmann, H Clevers, H Li, H Zhu, HF English, Isabelle Bisson, IV Litvinov, IV Litvinov, J Miki, JA Schalken, JE Visvader, JM Adams, KD Bunting, KG Leong, L Adam, L Patrawala, L Patrawala, L Patrawala, L Ricci-Vitiani, L Vezzoni, L Xin, L Xin, LE Pascal, LG Wang, M Al-Hajj, M Locke, M Verras, MJ Linja, MS Chen, MS Wicha, N Uchida, PN Kelly, RI Bhatt, S Signoretti, S Weiss, S Zhou, SI Hwang, SK Singh, SM Janes, SV Shmelkov, T Hara, T Nikolova, T Reya, WJ Huss, Y Katoh, Y Lu   +82 more
core   +1 more source

Association of Androgen-Receptor Gene Mutations with the Copy Number of Androgen-Receptor Silk Protein A Complex and Glutathione-S-Transferases T1 and M1 in Prostate Cancer Patients

Genetics Research, 2023
Objective. The purpose of our work was to explore the association of mutations in the androgen receptor gene and copy numbers of the androgen-receptor silk protein A complex with glutathione-S-transferases T1 and M1 in prostate cancer patients. Materials
Yan Zhang, Xiangdi Meng, Zhaosen Ma, Zhou Sun, Zhixin Wang   +4 more
doaj   +1 more source