Results 1 to 10 of about 231,777 (344)

The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity. [PDF]

PLoS ONE, 2012
Androgen receptor mediated signaling drives prostate cancer cell growth and survival. Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy but become prevalent in incurable androgen independent and metastatic ...
Colin W Hay, Iain J McEwan
doaj   +14 more sources

Androgen receptor mutations [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors.
Boehmer, A.L.M. (Annemie), Brinkmann, A.O. (Albert), Brüggenwirth, H.T. (Hennie), Jenster, G.W. (Guido), Korput, J.A.G.M. (J. A G M) van der, Ris-Stalpers, C. (Carolyn), Trapman, J. (Jan)   +6 more
core   +5 more sources

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

Cell Death and Disease, 2021
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio, Antimo Migliaccio, Anna Tesei, Gabriella Castoria   +12 more
doaj   +1 more source

Androgen Receptor Phosphorylation [PDF]

Endocrine Research, 1993
Phosphorylation of transcription factors plays an important role in regulation of gene expression. DNA-binding, transactivation activity, and subcellular trafficking of specific transcription factors have been shown to be regulated by phosphorylation/dephosphorylation.
L J, Blok, P E, de Ruiter, A O, Brinkmann   +2 more
openaire   +3 more sources

A Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes

Technology in Cancer Research & Treatment, 2021
Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is ...
Taobo Hu, Guiyang Zhao, Yiqiang Liu, Mengping Long   +3 more
doaj   +1 more source

Androgen receptor accelerates premature senescence of human dermal papilla cells in association with DNA damage. [PDF]

PLoS ONE, 2013
The dermal papilla, located in the hair follicle, expresses androgen receptor and plays an important role in hair growth. Androgen/Androgen receptor actions have been implicated in the pathogenesis of androgenetic alopecia, but the exact mechanism is not
Yi-Chien Yang, Hung-Chun Fu, Ching-Yuan Wu, Kuo-Ting Wei, Ko-En Huang, Hong-Yo Kang   +5 more
doaj   +1 more source

Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development. The cloning of the human androgen receptor cDNA and the elucidation of the genomic organization of the corresponding gene has enabled us to study androgen ...
Brinkmann, A. O., Kuiper, G. G., Ris-Stalpers, C., van Rooij, H. C., Romalo, G., Trifiro, M., Mulder, E., Pinsky, L., Schweikert, H. U., Trapman, J.   +9 more
openaire   +2 more sources

Androgen receptor status is a prognostic marker in non-basal triple negative breast cancers and determines novel therapeutic options. [PDF]

PLoS ONE, 2014
Triple negative breast cancers are a heterogeneous group of tumors characterized by poor patient survival and lack of targeted therapeutics. Androgen receptor has been associated with triple negative breast cancer pathogenesis, but its role in the ...
Pierluigi Gasparini, Matteo Fassan, Luciano Cascione, Gulnur Guler, Serdar Balci, Cigdem Irkkan, Carolyn Paisie, Francesca Lovat, Carl Morrison, Jianying Zhang, Aldo Scarpa, Carlo M Croce, Charles L Shapiro, Kay Huebner   +13 more
doaj   +1 more source

Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence

Cell Death Discovery, 2023
Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor.
Marzia Di Donato, Antimo Moretti, Carmela Sorrentino, Giuseppe Toro, Giulia Gentile, Giovanni Iolascon, Gabriella Castoria, Antimo Migliaccio   +7 more
doaj   +1 more source