Results 1 to 10 of about 2,496,118 (309)

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment

Cell Death and Disease, 2021
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio, Antimo Migliaccio, Anna Tesei, Gabriella Castoria   +12 more
doaj   +2 more sources

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer

Frontiers in Oncology, 2019
Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic ...
Qin Feng, Bin He, Bin He
doaj   +2 more sources

The Role of Androgen Receptor Signaling in Ovarian Cancer

Cells, 2019
Emerging evidence has suggested that androgen receptor signaling plays an important role in ovarian cancer outgrowth. Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor
Taichi Mizushima, Hiroshi Miyamoto
doaj   +2 more sources

Structure of the homodimeric androgen receptor ligand-binding domain

Nature Communications, 2017
The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface that ...
Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá   +13 more
doaj   +2 more sources

Truncation and constitutive activation of the androgen receptor by diverse genomic rearrangements in prostate cancer

Nature Communications, 2016
Castration-resistant prostate cancer frequently presents with persistent androgen receptor signalling. Here, the authors find that the androgen receptor is subject to genetic rearrangements, resulting in variants with ligand-independent activity.
Christine Henzler, Yingming Li, Rendong Yang, Terri McBride, Yeung Ho, Cynthia Sprenger, Gang Liu, Ilsa Coleman, Bryce Lakely, Rui Li, Shihong Ma, Sean R. Landman, Vipin Kumar, Tae Hyun Hwang, Ganesh V. Raj, Celestia S. Higano, Colm Morrissey, Peter S. Nelson, Stephen R. Plymate, Scott M. Dehm   +19 more
doaj   +2 more sources

The future of androgen receptor targeting in prostate cancer: third-generation inhibitors and beyond. [PDF]

Ther Adv Med Oncol
Bernard-Tessier A, Naoun N, Barraud S, Flippot R, Pobel C, Rey M, Baldini C, Massard C, Patrikidou A, Fuerea A, Di Palma M, Albigès L, Loriot Y, Fizazi K.   +13 more
europepmc   +2 more sources

Role of the androgen receptor in melanoma aggressiveness [PDF]

Cell Death and Disease
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall ...
Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria   +11 more
doaj   +2 more sources

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source

Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies

Cancers, 2021
Simple Summary Early-stage and castration-sensitive prostate cancer (PCa) growth is solely mediated by androgen signaling pathways. AR signaling inhibitors (ARSIs) have significantly improved clinical outcomes among men with PCa.
Aasems Jacob, Rishi Raj, Derek B. Allison, Zin W. Myint   +3 more
semanticscholar   +1 more source

A Machine Learning Approach to Differentiate Two Specific Breast Cancer Subtypes Using Androgen Receptor Pathway Genes

Technology in Cancer Research & Treatment, 2021
Triple-negative breast cancer is a heterogeneous disease with different molecular and histological subtypes. The Androgen receptor is expressed in a portion of triple-negative breast cancer cases and the activation of the androgen receptor pathway is ...
Taobo Hu, Guiyang Zhao, Yiqiang Liu, Mengping Long   +3 more
doaj   +1 more source