Results 1 to 10 of about 187,816 (375)

The androgen receptor/filamin A complex as a target in prostate cancer microenvironment [PDF]

Cell Death and Disease, 2021
Prostate cancer represents the major cause of cancer-related death in men and patients frequently develop drug-resistance and metastatic disease. Most studies focus on hormone-resistance mechanisms related to androgen receptor mutations or to the ...
Marzia Di Donato, Alice Zamagni, Giovanni Galasso, Erika Di Zazzo, Pia Giovannelli, Maria Vittoria Barone, Michele Zanoni, Roberta Gunelli, Matteo Costantini, Ferdinando Auricchio, Antimo Migliaccio, Anna Tesei, Gabriella Castoria   +12 more
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Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone [PDF]

Reproductive Biology and Endocrinology, 2005
Although 11-ketotestosterone is a potent androgen and induces male secondary sex characteristics in many teleosts, androgen receptors with high binding affinity for 11-ketotestosterone or preferential activation by 11-ketotestosterone have not been ...
Karlsson Johnny, Larsson Anders, Hellqvist Anna, Grahn Birgitta, von Hofsten Jonas, Berg A Håkan, Olsson Per-Erik, Modig Carina, Borg Bertil, Thomas Peter   +9 more
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The impact of point mutations in the human androgen receptor: classification of mutations on the basis of transcriptional activity. [PDF]

PLoS ONE, 2012
Androgen receptor mediated signaling drives prostate cancer cell growth and survival. Mutations within the receptor occur infrequently in prostate cancer prior to hormonal therapy but become prevalent in incurable androgen independent and metastatic ...
Colin W Hay, Iain J McEwan
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Androgen regulation of the androgen receptor coregulators [PDF]

BMC Cancer, 2008
Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also
Helenius Merja A, Suikki Hanna E, Waltering Kati K, Urbanucci Alfonso, Visakorpi Tapio   +4 more
doaj   +5 more sources

Androgen receptor mutations [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1995
Male sexual differentiation and development proceed under direct control of androgens. Androgen action is mediated by the intracellular androgen receptor, which belongs to the superfamily of ligand-dependent transcription factors.
Boehmer, A.L.M. (Annemie), Brinkmann, A.O. (Albert), Brüggenwirth, H.T. (Hennie), Jenster, G.W. (Guido), Korput, J.A.G.M. (J. A G M) van der, Ris-Stalpers, C. (Carolyn), Trapman, J. (Jan)   +6 more
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Severe forms of partial androgen insensitivity syndrome due to p.L830F novel mutation in androgen receptor gene in a Brazilian family [PDF]

BMC Research Notes, 2011
Background The androgen insensitivity syndrome may cause developmental failure of normal male external genitalia in individuals with 46,XY karyotype.
Guerra-Junior Gil, de Calais Flávia L, Soardi Fernanda C, Maciel-Guerra Andréa T, Petroli Reginaldo J, de Mello Maricilda   +5 more
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Role of the androgen receptor in melanoma aggressiveness [PDF]

Cell Death and Disease
Malignant melanoma represents the fifth most common cancer in the world and its incidence is rising. Novel therapies targeting receptor tyrosine kinases, kinases and immune checkpoints have been employed with a significant improvement of the overall ...
Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna, Lucia Carmela Passacatini, Margaret Ottaviano, Paolo Antonio Ascierto, Ferdinando Auricchio, Ennio Carbone, Antimo Migliaccio, Gabriella Castoria   +11 more
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Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen. [PDF]

, 1993
Autoregulation is a control mechanism common to several proteins of the steroid/thyroid hormone receptor superfamily. In this work the effect of androgens and antiandrogens on the expression of the human androgen receptor (hAR) in prostate and breast ...
Blasschke, Dorothea, Hermeking, Heiko, Herzinger, Thomas, Hörz, Wolfram, Wolf, Dieter A.   +4 more
core   +2 more sources

Androgen receptor abnormalities [PDF]

The Journal of Steroid Biochemistry and Molecular Biology, 1991
The human androgen receptor is a member of the superfamily of steroid hormone receptors. Proper functioning of this protein is a prerequisite for normal male sexual differentiation and development.
Brinkmann, A.O. (Albert), Kuiper, G.G.J.M. (George), Mulder, E. (Eppo), Pinsky, L. (L.), Ris-Stalpers, C. (Carolyn), Romalo, G. (G.), Rooij, H.C.J. (Henri) van, Schweikert, H.U. (H.), Trapman, J. (Jan), Trifirò, G. (Gianluca)   +9 more
core   +5 more sources

What Does Androgen Receptor Signaling Pathway in Sertoli Cells During Normal Spermatogenesis Tell Us?

Frontiers in Endocrinology, 2022
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes. Difference between androgen binding location in Sertoli cell classifies androgen receptor signaling pathway into classical signaling pathway and non-classical ...
Jia-Ming Wang, Zhen-Fang Li, Wan-Xi Yang
doaj   +1 more source