Results 51 to 60 of about 25,474 (169)

A synthetic peptide rescues rat cortical neurons from anesthetic-induced cell death, perturbation of growth and synaptic assembly

Scientific Reports, 2021
Anesthetics are deemed necessary for all major surgical procedures. However, they have also been found to exert neurotoxic effects when tested on various experimental models, but the underlying mechanisms remain unknown.
Fahad Iqbal, Marcus Pehar, Andrew J. Thompson, Urva Azeem, Kiana Jahanbakhsh, Nerea Jimenez-Tellez, Rasha Sabouny, Shadab Batool, Atika Syeda, Jennifer Chow, Pranav Machiraju, Timothy Shutt, Kamran Yusuf, Jane Shearer, Tiffany Rice, Naweed I. Syed   +15 more
doaj   +1 more source

Inhalational Anesthetics Do Not Deteriorate Amyloid-beta-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level

, 2021
Background: Studies suggest that general anesthetics like isoflurane and sevoflurane may aggravate Alzheimer's disease (AD) neuropathogenesis, e.g., increased amyloid-beta (A beta) protein aggregation resulting in synaptotoxicity and cognitive ...
Hadian, K., Borgstedt, L., Ebert, T., Jungwirth, B., Rammes, G., Buerge, M., Kopp, C., Wotjak, C., Kreuzer, M., Hofmann, C., Sander, A., Schorpp, K., Ruitenberg, M., Wang, X., Parsons, C.   +14 more
core   +1 more source

Continuous Respiratory Oscillometry in Pediatric Laparoscopic Surgery—The COMET Study

Pediatric Anesthesia, EarlyView.
ABSTRACT Background Laparoscopic appendectomy is the accepted surgical approach for appendicitis in centers worldwide. Laparoscopic surgery requires the creation of a pneumoperitoneum to facilitate surgical access. Laparoscopic surgery affects the respiratory mechanics of patients under general anesthesia.
Neil Hauser, Emanuela Zannin, Julie Nguyen, Anwen Taplin, Sara Vigevani, David Sommerfield, Raffaele Dellaca, R. Nazim Khan, Aine Sommerfield, Britta S. von Ungern‐Sternberg   +9 more
wiley   +1 more source

“Testicular Torsion in a Child With CPT‐1 Deficiency and History of Viral Myositis: Anesthesia Considerations”

Clinical Case Reports
Tailored anesthetic management is crucial for pediatric patients with inborn metabolic disorders like CPT‐1 deficiency and conditions, such as viral myositis. Avoiding inhalational anesthetics and succinylcholine, using glucose infusion, safe anesthetics,
Samuel Grant Volpe, Aariya Srinivasan, Sabry Ayad   +2 more
doaj   +1 more source

General Anesthetics: Aspects of Chirality, Pharmacodynamics, and Pharmacokinetics

Pharmaceuticals
The introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the
Ružena Čižmáriková, Ladislav Habala, Jindra Valentová   +2 more
doaj   +1 more source

Adverse effect of inhalational anesthetics on the developing brain [PDF]

, 2014
We did a PubMed search and summarized studies on the potential adverse effect of anesthetics especially neurotoxicity in the developing brain, so named anesthesia-induced developmental neurotoxicity.
John H Zhang, Applegate, Richard L, Richard L Applegate, Zhang, John H, Mike Wang, Wang, Mike   +5 more
core   +1 more source

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

Phytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen, Xin Dong, Haowen Zhuang, Yusheng Huang, Mengyuan Wang, Zhongzheng Zhang, Jinhong Chen, Wei Wang, Chun Li, Junyan Wang   +9 more
wiley   +1 more source

Consent for anaesthesia: guidelines from the Association of Anaesthetists

Anaesthesia, EarlyView.
Summary Introduction Guidelines on consent for anaesthesia were first issued by the Association of Anaesthetists in 1999 and last revised in 2017. These new guidelines respond to the changing ethical, legal and clinical landscape in which anaesthetists practice. Since 2017, the Montgomery judgment has changed medical consent practice.
Andrew McLeod, David Bogod, James Brooks, Michael Devlin, Natalie Joseph‐Williams, Rehana Iqbal, Nadine Montgomery‐Allam, Felicity Plaat, Alex Ruck Keene, Cliff Shelton, Vinnie Sodhi, Michael Swart, Emma Wain, Hugo Wellesley, Jenny Westaway   +14 more
wiley   +1 more source

Evaluation of Waste Anesthetic Gas in the Postanesthesia Care Unit within the Patient Breathing Zone

Anesthesiology Research and Practice, 2015
Potential health hazards from waste anesthetic gases (WAGs) have been a concern since the introduction of inhalational anesthetics into clinical practice.
Kenneth N. Hiller, Alfonso V. Altamirano, Chunyan Cai, Stephanie F. Tran, George W. Williams   +4 more
doaj   +1 more source

Malignant hyperthermia

Вестник медицинского института «Реавиз»: Реабилитация, врач и здоровье, 2022
Malignant hyperthermia manifests as hypermetabolism of striated voluntary muscle. Generally, this condition occurs during general anesthesia when inhalational anesthetics and succinylcholine are used.
S. N. Ionov, M. V. Sharavina, Yu. S. Makhnycheva   +2 more
doaj   +1 more source