Results 11 to 20 of about 16,714,816 (218)

Angiopoietin-like-4 and minimal change disease. [PDF]

PLoS ONE, 2017
BACKGROUND:Minimal Change Disease (MCD) is the most common type of nephrotic syndrome in children. Angiopoietin-like-4 (Angplt4) has been proposed as mediator of proteinuria in MCD. The aim of this study was to evaluate the role of Angptl4 as a biomarker
Gabriel Cara-Fuentes, Alfons Segarra, Cecilia Silva-Sanchez, Heiman Wang, Miguel A Lanaspa, Richard J Johnson, Eduardo H Garin   +6 more
doaj   +5 more sources

Angiopoietin-like 4 regulates epidermal differentiation.

PLoS ONE, 2011
The nuclear hormone receptor PPARβ/δ is integral to efficient wound re-epithelialization and implicated in epidermal maturation. However, the mechanism underlying the latter process of epidermal differentiation remains unclear.
Mintu Pal, Ming Jie Tan, Royston-Luke Huang, Yan Yih Goh, Xiao Ling Wang, Mark Boon Yang Tang, Nguan Soon Tan   +6 more
doaj   +6 more sources

Angiopoietin-like 4: a decade of research [PDF]

Bioscience Reports, 2011
The past decade has seen a rapid development and increasing recognition of ANGPTL4 (angiopoietin-like 4) as a remarkably multifaceted protein that is involved in many metabolic and non-metabolic conditions. ANGPTL4 has been recognised as a central player in various aspects of energy homoeostasis, at least in part, via the inhibitory interaction between
Zhu, P., Goh, Y.Y., Chin, H.F.A., Kersten, A.H., Tan, N.S.   +4 more
core   +7 more sources

GPIHBP1 stabilizes lipoprotein lipase and prevents its inhibition by angiopoietin-like 3 and angiopoietin-like 4 [PDF]

Journal of Lipid Research, 2009
Glycosylphosphatidylinositol-anchored HDL-binding protein (GPIHBP1) binds both LPL and chylomicrons, suggesting that GPIHBP1 is a platform for LPL-dependent processing of triglyceride (TG)-rich lipoproteins.
William K. Sonnenburg, Daiguan Yu, E-Chiang Lee, Wei Xiong, Gennady Gololobov, Billie Key, Jason Gay, Nat Wilganowski, Yi Hu, Sharon Zhao, Matthias Schneider, Zhi-Ming Ding, Brian P. Zambrowicz, Greg Landes, David R. Powell, Urvi Desai   +15 more
doaj   +3 more sources

Angiopoietin-Like Protein 4 and Insulin-Like Growth Factor-1 Expression in Invasive Breast Carcinoma in Young Women

Pathophysiology, 2022
Biomarker identification is imperative for invasive breast carcinoma, which is more aggressive and associated with higher mortality and worse prognosis in younger patients (50 years).
Zaleha Kamaludin, Alaa Siddig, Najib Majdi Yaacob, Alfred K. Lam, Wan Faiziah Wan Abdul Rahman   +4 more
doaj   +2 more sources

Angiopoietin-like 4 based therapeutics for proteinuria and kidney disease [PDF]

Frontiers in Pharmacology, 2014
Current drugs used to treat proteinuric disorders of the kidney have been borrowed from other branches of medicine, and are only partially effective. The discovery of a central, mechanistic role played by two different forms of the secreted glycoprotein ...
Sumant Singh Chugh, Camille eMace, Lionel C Clement, Maria eDel Nogal Avila, Caroline eMarshall   +4 more
doaj   +3 more sources

Differential regulation and properties of angiopoietin-like proteins 3 and 4 [PDF]

Journal of Lipid Research, 2005
Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge, Ji-Young Cha, Harini Gopal, Christopher Harp, Xinxin Yu, Joyce J. Repa, Cai Li   +6 more
doaj   +3 more sources

Emerging Roles of Angiopoietin-like 4 in Human Cancer [PDF]

Molecular Cancer Research, 2012
Abstract Angiopoietin-like 4 (ANGPTL4) is best known for its role as an adipokine involved in the regulation of lipid and glucose metabolism. The characterization of ANGPTL4 as an adipokine is largely due to our limited understanding of the interaction partners of ANGPTL4 and how ANGPTL4 initiates intracellular signaling. Recent findings
Tan, Ming Jie, Teo, Ziqiang, Sng, Ming Keat, Zhu, Pengcheng, Tan, Nguan Soon   +4 more
openaire   +4 more sources

Angiopoietin-like 4 (Angptl4) [PDF]

, 2012
Angiopoietin-like 4 (Angptl4) is a secreted protein modulating triacylglycerol homeostasis. Its transcription is induced by glucocorticoids, which act to elevate circulating Angptl4 levels during fasting. In investigating the role of Angptl4 in glucocorticoid action, we identified that in addition to its known ability to inhibit lipoprotein lipase ...
Koliwad, Suneil K, Gray, Nora E, Wang, Jen-Chywan   +2 more
openaire   +4 more sources

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
Objective— To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants. Methods and Results— Plasma Angptl4 was ...
Smart-Halajko, MC, Robciuc, MR, Cooper, JA, Jauhiainen, M, Kumari, M, Kivimaki, M, Khaw, KT, Boekholdt, SM, Wareham, NJ, Gaunt, TR, Day, IN, Braund, PS, Nelson, CP, Hall, AS, Samani, NJ, Humphries, SE, Ehnholm, C, Talmud, PJ   +17 more
openaire   +5 more sources