Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes [PDF]
Journal of Lipid Research, 2016 LPL hydrolyzes triglycerides in triglyceride-rich lipoproteins along the capillaries of heart, skeletal muscle, and adipose tissue. The activity of LPL is repressed by angiopoietin-like 4 (ANGPTL4) but the underlying mechanisms have not been fully ...
Wieneke Dijk +5 more
doaj +2 more sources
Angiopoietin-like 4 promotes osteosarcoma cell proliferation and migration and stimulates osteoclastogenesis [PDF]
BMC Cancer, 2018 Background Osteosarcoma is the most common primary bone cancer in children and young adults. It is highly aggressive and patients that present with metastasis have a poor prognosis.
T. Zhang +4 more
doaj +2 more sources
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting [PDF]
Molecular Metabolism, 2017 Objective: Angiopoietin-like 4 (ANGPTL4) is a fasting-induced inhibitor of lipoprotein lipase (LPL) and a regulator of plasma triglyceride metabolism. Here, we examined the kinetics of Angptl4 induction and tested the hypothesis that ANGPTL4 functions ...
Emily M. Cushing +5 more
doaj +2 more sources
Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity [PDF]
Frontiers in Immunology, 2019 Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system (CNS) characterized by the presence of focal demyelinated plaques.
Alwin Kamermans +5 more
doaj +2 more sources
Targeting metabolic flexibility via angiopoietin-like 4 protein sensitizes metastatic cancer cells to chemotherapy drugs [PDF]
Molecular Cancer, 2018 Overcoming multidrug resistance has always been a major challenge in cancer treatment. Recent evidence suggested epithelial-mesenchymal transition plays a role in MDR, but the mechanism behind this link remains unclear.
Maegan Miang Kee Lim +10 more
doaj +2 more sources
Angiopoietin‐like protein 4 and clinical outcomes in ischemic stroke patients
Annals of Clinical and Translational Neurology, 2021 Aims Angiopoietin‐like protein 4 (ANGPTL‐4) had been reported to be associated with the risk of ischemic stroke, but its prognostic value remained unclear.
Xiaowei Zheng +13 more
doaj +1 more source
Role of Angiopoietin-like protein 4 (ANGPTL4) as a Predictive marker for Diabetic Nephropathy in type 2 Diabetes [PDF]
Al-Azhar International Medical Journal, 2022 Background: Angiopoietin-like protein 4 (ANGPTL4) is a glycoprotein that regulates LPL activity during fasting and thereby affects triglyceride metabolism.
Amr Rezk +3 more
doaj +1 more source
The Prognostic Value of ANGPTL-4 in Acute Coronary Syndrome: A Prospective Cohort Study [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Coronary Artery Disease (CAD) is one of the leading causes of mortality and morbidity worldwide and Acute Coronary Syndrome (ACS) is one of the predominant causes of Cardiovascular Deaths (CVD).
Luxitaa Goenka +4 more
doaj +1 more source
Angiopoietin-like protein 4 regulates breast muscle lipid metabolism in broilers
Poultry Science, 2021 : The objective of this study was to determine the effects of angiopoietin-like protein 4 (ANGPTL4) on breast muscle lipid metabolism in broilers. In experiment 1, 36 thirty-five-day-old male Arbor Acres broilers were randomly allocated into 6 treatment ...
Xu Zhao +5 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince +30 more
wiley +1 more source