Results 11 to 20 of about 107,653,743 (272)

Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

Haematologica, 2008
Neoangiogenesis is involved in the pathophysiology of multiple myeloma and angiopoietins possibly contribute to myeloma-induced neovascularization. Bortezomib’s antineoplastic potential includes an anti-angiogenic effect.
Konstantinos Anargyrou, Evangelos Terpos, Theodoros P. Vassilakopoulos, Anastasia Pouli, Sotirios Sachanas, Tatiana Tzenou, Stavroula Masouridis, Dimitrios Christoulas, Maria K. Angelopoulou, Evangelia M. Dimitriadou, Christina Kalpadakis, Konstantinos Tsionos, Panayiotis Panayiotidis, Meletios A. Dimopoulos, Gerassimos A. Pangalis, Marie-Christine Kyrtsonis   +15 more
doaj   +3 more sources

Angiopoietin-1 deficiency increases tumor metastasis in mice [PDF]

BMC Cancer, 2017
Background Angipoietin-1 activation of the tyrosine kinase receptor Tek expressed mainly on endothelial cells leads to survival and stabilization of endothelial cells. Studies have shown that Angiopoietin-1 counteracts permeability induced by a number of
Iacovos P. Michael, Martina Orebrand, Marta Lima, Beatriz Pereira, Olga Volpert, Susan E. Quaggin, Marie Jeansson   +6 more
doaj   +3 more sources

Effects of laser photocoagulation on serum angiopoietin-1, angiopoietin-2, angiopoietin-1/angiopoietin-2 ratio, and soluble angiopoietin receptor Tie-2 levels in type 2 diabetic patients with proliferative diabetic retinopathy [PDF]

International Journal of Ophthalmology, 2014
AIM: To determine the effects of laser photocoagulation on serum levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), soluble angiopoietin receptor Tie-2 (Tie-2), Ang-1/Ang-2 ratio and vascular endothelial growth factor (VEGF) in patients with type ...
Qiao-Ying You, Fu-Yuan Zhuge, Qi-Qian Zhu, Xu-Wei Si   +3 more
doaj   +3 more sources

Advanced Glycation End-Products and Hyperglycemia Increase Angiopoietin-2 Production by Impairing Angiopoietin-1-Tie-2 System

Journal of Diabetes Research, 2019
The angiopoietin-Tie-2 system plays a crucial role in the maintenance of endothelial integrity. Hyperglycemia and advanced glycation end-products (AGEs) are involved in endothelial cell dysfunction responsible of the pathogenesis of microvascular ...
Alessandra Puddu, Roberta Sanguineti, Davide Maggi, Massimo Nicolò, Carlo E. Traverso, Renzo Cordera, Giorgio L. Viviani   +6 more
doaj   +3 more sources

Angiopoietin-1, angiopoietin-2 and bicarbonate as diagnostic biomarkers in children with severe sepsis. [PDF]

PLoS ONE, 2014
Severe pediatric sepsis continues to be associated with high mortality rates in children. Thus, an important area of biomedical research is to identify biomarkers that can classify sepsis severity and outcomes.
Kun Wang, Vineet Bhandari, John S Giuliano, Corey S O Hern, Mark D Shattuck, Michael Kirby   +5 more
doaj   +4 more sources

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Videosurgery and Other Miniinvasive Techniques, 2011
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis.
Joanna Kalupa, Krzysztof Kuzdak, Krzysztof Kołomecki   +2 more
doaj   +1 more source

Glycation of Tie-2 Inhibits Angiopoietin-1 Signaling Activation and Angiopoietin-1-Induced Angiogenesis. [PDF]

Int J Mol Sci, 2022
The impairment of the angiopoietin-1 (Ang-1)/Tie-2 signaling pathway has been thought to play a critical role in diabetic complications. However, the underlying mechanisms remain unclear. The present study aims to investigate the effects of Tie-2 glycation on Ang-1 signaling activation and Ang-1-induced angiogenesis.
Zhou H, Chen T, Li Y, You J, Deng X, Chen N, Li T, Zheng Y, Li R, Luo M, Wu J, Wang L.   +11 more
europepmc   +3 more sources

Serum Angiopoietin-1/Angiopoietin-2 at 16-18 Weeks of Gestation to Predict Preeclampsia [PDF]

, 2021
Objective: To determine whether serum angiopoietin-1/angiopoietin-2 ratio can predict preeclampsia in women at 16–18 weeks of gestation, or not. Material and Methods: This was a prospective observational study that was conducted in pregnant women with ...
Ruangsak Lertkhachonsuk, Patau Tanbirojn, Vorapong Phupong   +2 more
core   +1 more source

Angiopoietin-1/Angiopoietin-2 Ratio for Prediction of Preeclampsia [PDF]

American Journal of Hypertension, 2009
A number of different biophysical and biochemical markers have been proposed as predictors of preeclampsia. Factors involved in the angiogenic balance are suggested as candidate markers. The purpose of this prospective, longitudinal cohort study was to determine whether a ratio between Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) can be used to ...
Marie, Bolin, Eva, Wiberg-Itzel, Anna-Karin, Wikström, Margareta, Goop, Anders, Larsson, Matts, Olovsson, Helena, Akerud   +6 more
openaire   +2 more sources

Angiopoietins modulate endothelial adaptation, glomerular and podocyte hypertrophy after uninephrectomy. [PDF]

PLoS ONE, 2013
Glomerular capillary remodeling is an essential process in the development of glomerular hypertrophy. Angiopoietins, which are important regulators in angiogenesis, plays a role in the development of glomerulus during embryogenesis.
Wen Chih Chiang, Chun Fu Lai, Chi Ting Su, Wei Hao Peng, Ching Fang Wu, Fan Chi Chang, Yi Ting Chen, Shuei Liong Lin, Yung Ming Chen, Kwan Dun Wu, Kuo Shyan Lu, Tun Jun Tsai   +11 more
doaj   +1 more source