Results 31 to 40 of about 107,653,743 (272)

sj-docx-1-vrd-10.1177_24741264221126061 – Supplemental material for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial

, 2022
Supplemental material, sj-docx-1-vrd-10.1177_24741264221126061 for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial by Jeffrey S. Heier, Allen C. Ho, David S. Boyer, Karl Csaky, Robert Vitti,
Friedrich Asmus (14327961), Lorah Perlee (14327955), Robert Vitti (14327952), Karl Csaky (2686657), Allen C. Ho (13152645), Karen W. Chu (14327958), Sergio Leal (9140146), Oliver Zeitz (71487), Thomas Schmelter (796965), Yenchieh Cheng (14327964), Jeffrey S. Heier (14327946), David S. Boyer (14327949), David M. Brown (475802)   +12 more
core   +1 more source

Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis.

PLoS ONE, 2013
Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension.
Rukshana C Shroff, Karen L Price, Maria Kolatsi-Joannou, Alexandra F Todd, David Wells, John Deanfield, Richard J Johnson, Lesley Rees, Adrian S Woolf, David A Long   +9 more
doaj   +1 more source

Vascular stabilization by angiopoietin-1

Folia Pharmacologica Japonica, 2010
アンジオポエチン–1（Ang1）は，血管内皮細胞に発現するTie2受容体を介して，血管構造の安定化と血管新生の相反する機能を制御している．Ang1-Tie2シグナルは内皮細胞間接着によって空間的，機能的に制御されている．細胞間接着を有する内皮細胞において，Ang1はTie2のトランス結合を形成し血管安定化シグナルを活性化する．一方，細胞間接着を持たない内皮細胞では，Ang1はTie2を細胞—基質接着部位にターゲットすることで，血管新生シグナルを惹起する．細胞間接着部位でトランス結合したTie2は，Akt経路を介して，内皮細胞の生存促進作用および抗炎症作用を発揮すると共に，内皮細胞間接着を増強することで，血管構造の安定化に寄与している．血管の不安定化は，様々な疾患の発症と密接に関連しているが ...
Fukuhara, Shigetomo, Mochizuki, Naoki
openaire   +3 more sources

Wound healing potential: evaluation of molecular profiling and amplification of Lucilia sericata angiopoietin-1 mRNA mid-part

BMC Research Notes, 2020
Objective High prevalence of chronic ulcers and the burden of disease necessitate the increasingly significant production of new recombinant proteins in the world.
Hamzeh Alipour, Marziae Shahriari-Namadi, Saeedeh Ebrahimi, Mohammad D. Moemenbellah-Fard   +3 more
doaj   +1 more source

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

PLoS ONE, 2023
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males.
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom   +8 more
doaj   +1 more source

Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction

Experimental and Therapeutic Medicine, 2013
The aim of the present study was to investigate the association of the serum angiopoietin (Ang)-1 and Ang-2 levels and the Ang-2 to Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients with acute myocardial infarction (AMI) during hospitalization. The serum Ang-1 and Ang-2 levels of the AMI patients were measured at admission to hospital.
CHEN, SHAOMIN, GUO, LIJUN, CHEN, BAOXIA, SUN, LIJIE, CUI, MING   +4 more
openaire   +3 more sources

Suppression of Diabetic Retinopathy with Angiopoietin-1 [PDF]

The American Journal of Pathology, 2002
Diabetic retinopathy remains a leading cause of irreversible blindness. A critical early pathology in the disease is the adhesion of leukocytes to the retinal vasculature, a process that occurs, in part, via intercellular adhesion molecule-1. Once leukocyte adhesion occurs, endothelial cell injury ensues, as does blood-retinal barrier breakdown.
Antonia M, Joussen, Vassiliki, Poulaki, Akitaka, Tsujikawa, Wenying, Qin, Tamim, Qaum, Qingwen, Xu, Yasufumi, Moromizato, Sven-Erik, Bursell, Stanley J, Wiegand, John, Rudge, Ella, Ioffe, George D, Yancopoulos, Anthony P, Adamis   +12 more
openaire   +2 more sources

A Functional RNAi Screen for Runx2-Regulated Genes Associated With Ectopic Bone Formation in Human Spinal Ligaments

Journal of Pharmacological Sciences, 2008
Ossification of the posterior longitudinal ligament of the spine (OPLL) is characterized by ectopic ossification in the spinal ligaments, which enlarges with time and compresses the spinal cord, resulting in serious neurological symptoms.
Masaki Kishiya, Toshitada Sawada, Kohta Kanemaru, Hitoshi Kudo, Takuya Numasawa, Toru Yokoyama, Sunao Tanaka, Shigeru Motomura, Kazumasa Ueyama, Seiko Harata, Satoshi Toh, Ken-Ichi Furukawa   +11 more
doaj   +1 more source

Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19

Artery Research, 2023
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation of patients with
Carolien Volleman, Roselique Ibelings, Alexander P. J. Vlaar, Charissa E. van den Brom, The Amsterdam UMC COVID-19 Biobank Study Group   +4 more
doaj   +1 more source

Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes

BMC Nephrology, 2020
Background We previously identified two acute kidney injury (AKI) sub-phenotypes (AKI-SP1 and AKI-SP2) with different risk of poor clinical outcomes and response to vasopressor therapy.
Pavan K. Bhatraju, Max Cohen, Ryan J. Nagao, Eric D. Morrell, Susanna Kosamo, Xin-Ya Chai, Robin Nance, Victoria Dmyterko, Joseph Delaney, Jason D. Christie, Kathleen D. Liu, Carmen Mikacenic, Sina A. Gharib, W. Conrad Liles, Ying Zheng, David C. Christiani, Jonathan Himmelfarb, Mark M. Wurfel   +17 more
doaj   +1 more source