Results 111 to 120 of about 5,344 (155)
Some of the next articles are maybe not open access.
European Journal of Surgical Oncology, 2007
Tumour growth is dependant upon the development of an adequate blood supply. This, in turn, is thought to depend upon a switch by the tumour, from a dormant to angiogenic state. Recent data suggest that this switch may occur when the balance of pro- and anti-angiogenic agents alters to promote angiogenesis. Angiopoietins may be involved in this balance.
D Burke
exaly +3 more sources
Tumour growth is dependant upon the development of an adequate blood supply. This, in turn, is thought to depend upon a switch by the tumour, from a dormant to angiogenic state. Recent data suggest that this switch may occur when the balance of pro- and anti-angiogenic agents alters to promote angiogenesis. Angiopoietins may be involved in this balance.
D Burke
exaly +3 more sources
Angiopoietins and Angiopoietin-Like Proteins in Angiogenesis
Endothelium, 2006Vascular network formation requires several endothelial cell growth factors. These factors have a potent angiogenic effect, and their precise coordination is essential for vascular development. Among them, angiopoietins function through the Tie2 receptor, whose signaling is critical to regulate vascular stabilization and remodeling.
Tohru, Morisada +4 more
openaire +2 more sources
Angiopoietins in angiogenesis and beyond
Expert Opinion on Investigational Drugs, 2003 The angiopoietin (Ang) family of growth factors includes four members, all of which bind to the endothelial receptor tyrosine kinase Tie2. Two of the Angs, Ang-1 and Ang-4, activate the Tie2 receptor, whereas Ang-2 and Ang-3 inhibit Ang-1-induced Tie2 phosphorylation.
Andreas Papapetropoulos
exaly +5 more sources
Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma
Journal of Hepatology, 2004Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC.The expression of Angiopoietin-1 and Angiopoietin-2 mRNAs in cultured hepatoma cells under hypoxic conditions and in HCC and ...
Takuji, Torimura +13 more
openaire +2 more sources
Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development
Current Oncology Reports, 2019The purpose of this review is to discuss the current understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis. This review also focuses on preclinical and clinical data published to date that have evaluated Tie2-angiopoietin inhibition.Tie2 inhibition has shown significant promise in preclinical models, notable for ...
Jessica, Gillen +2 more
openaire +2 more sources
Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis
International Journal of Hematology, 2004A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Yuichi, Oike +2 more
openaire +2 more sources
Angiopoietins in tumours: the angiogenic switch
Journal of Pathology, 2004AbstractOn first view, the literature pertaining to the expression of the angiopoietins in tumours is confusing and does not readily offer a consensus pattern. Apparently conflicting publications report increased, decreased or unchanged expression levels of both angiopoietin‐1 (Ang‐1) and angiopoietin‐2 (Ang‐2) in a wide range of tumours.
Pamela F Jones
exaly +3 more sources
2009
The formation of new blood vessels plays an important role during the development and progression of a disease. In recent years, there has been a tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues. Angiopoietins belong to a family of growth factors that are critically involved in blood vessel formation
openaire +2 more sources
The formation of new blood vessels plays an important role during the development and progression of a disease. In recent years, there has been a tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues. Angiopoietins belong to a family of growth factors that are critically involved in blood vessel formation
openaire +2 more sources
The Role of the Angiopoietins in Tumour Angiogenesis
Growth Factors, 2004Angiogenesis--the growth of new blood vessels from existing ones--is a prerequisite for the growth of solid tumours beyond a diameter of approximately 2 mm. In recent years, the angiopoietins have emerged as important regulators of angiogenesis. They mediate a delicate balance between vascular quiescence, regression and new growth, but their mechanism ...
B D Sleeman +2 more
exaly +3 more sources
Angiopoietin signaling in the vasculature
Experimental Cell Research, 2013The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and lymphatic vessel development, and vascular permeability, inflammation, angiogenic remodeling and tumor vascularization in adult tissues. The angiopoietins activate the Tie receptors in unique in trans complexes at endothelial cell-cell and cell-matrix contacts ...
Lauri, Eklund, Pipsa, Saharinen
openaire +2 more sources