Results 181 to 190 of about 5,425 (227)

Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma

Journal of Hepatology, 2004
Hepatocellular carcinoma (HCC) is a highly vascular tumor. Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis. We investigated the expression of Angiopoietin-1 and Angiopoietin-2 in HCC.The expression of Angiopoietin-1 and Angiopoietin-2 mRNAs in cultured hepatoma cells under hypoxic conditions and in HCC and ...
Takuji, Torimura, Takato, Ueno, Motoaki, Kin, Riko, Harada, Eitaro, Taniguchi, Toru, Nakamura, Ryuichiro, Sakata, Osamu, Hashimoto, Masaharu, Sakamoto, Ryukichi, Kumashiro, Michio, Sata, Osamu, Nakashima, Hirohisa, Yano, Masamichi, Kojiro   +13 more
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Angiopoietin-1 and Angiopoietin-2 Inhibitors: Clinical Development

Current Oncology Reports, 2019
The purpose of this review is to discuss the current understanding of the Tie2-angiopoietin system and its role in tumor growth and metastasis. This review also focuses on preclinical and clinical data published to date that have evaluated Tie2-angiopoietin inhibition.Tie2 inhibition has shown significant promise in preclinical models, notable for ...
Jessica, Gillen, Debra, Richardson, Kathleen, Moore   +2 more
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Angiopoietin-Related/Angiopoietin-Like Proteins Regulate Angiogenesis

International Journal of Hematology, 2004
A general understanding of the molecular mechanisms underlying angiogenesis is emerging from the analysis of targeted mutations in vasculature-related genes. These analyses reveal that angiopoietin signaling through the TIE2 receptor is involved in regulating angiogenesis.
Yuichi, Oike, Kunio, Yasunaga, Toshio, Suda   +2 more
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Angiopoietins

2009
The formation of new blood vessels plays an important role during the development and progression of a disease. In recent years, there has been a tremendous effort to uncover the molecular mechanisms that drive blood vessel growth in adult tissues. Angiopoietins belong to a family of growth factors that are critically involved in blood vessel formation
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Angiopoietin signaling in the vasculature

Experimental Cell Research, 2013
The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and lymphatic vessel development, and vascular permeability, inflammation, angiogenic remodeling and tumor vascularization in adult tissues. The angiopoietins activate the Tie receptors in unique in trans complexes at endothelial cell-cell and cell-matrix contacts ...
Lauri, Eklund, Pipsa, Saharinen
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Angiopoietins

2015
Copyright Holder: Springer-Verlag Berlin ...
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Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2

Cytogenetic and Genome Research, 2001
The family of human angiopoietins comprises factors with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to the endothelial cell-specific receptor, Tie2. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting ...
E G, Ward, K, Grosios, A F, Markham, P F, Jones   +3 more
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Molecular control of angiopoietin signalling

Biochemical Society Transactions, 2011
The angiopoietins act through the endothelial receptor tyrosine kinase Tie2 to regulate vessel maturation in angiogenesis and control quiescence and stability of established vessels. The activating ligand, Ang1 (angiopoietin-1), is constitutively expressed by perivascular cells, and the ability of endothelial cells to respond to the ligand is ...
Singh, H, Tahir, TA, Alawo, DOA, Issa, E, Brindle, NPJ   +4 more
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Angiopoietin-2 in CLL

Blood, 2010
Elevated plasma levels of the angiogenic factor Ang-2 correlated with poor prognosis in a larger series of CLL patients. Ang-2 levels may reflect crosstalk between CLL cells and their microenvironment, specifically related to angiogenesis and endothelial cells, and therefore emphasize the importance of angiogenesis in CLL. .
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Balance between Angiopoietin-1 and Angiopoietin-2 Is in Favor of Angiopoietin-2 in Atherosclerotic Plaques with High Microvessel Density

Journal of Vascular Research, 2008
<i>Introduction:</i> Atherosclerotic plaque microvessels are associated with plaque hemorrhage and rupture. The mechanisms underlying plaque angiogenesis are largely unknown. Angiopoietin (Ang)-1 and -2 are ligands of the endothelial receptor Tie-2.
Simone, Post, Wouter, Peeters, Els, Busser, Dennis, Lamers, Joost P G, Sluijter, Marie-José, Goumans, Roel A, de Weger, Frans L, Moll, Pieter A, Doevendans, Gerard, Pasterkamp, Aryan, Vink   +10 more
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