Results 21 to 30 of about 34,611,245 (244)

Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]

, 2014
GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G., Francesca Magnani, Jones, Emma S., Gerothanassis, Ioannis P., Emma S. Jones, Andreas G. Tzakos, Widdop, Robert E., Crook, Tim, Ishiguro, Susumu, Charalampos G. Pappas, Vassiliki Magafa, Tzakos, Andreas G., Naomi Ohta (735090), Jana Selent, Paul Cordopatis, Susumu Ishiguro, Ioannis P. Gerothanassis, Ohta, Naomi, Andreas G. Tzakos (1327620), Tim Crook, Naomi Ohta, Francesca Magnani (1327608), Ioannis P. Gerothanassis (1327626), Masaaki Tamura, Paul Cordopatis (1327614), Cordopatis, Paul, Sanja Bosnyak, Jana Selent (147923), Emma S. Jones (1327623), Robert E. Widdop (585063), Selent, Jana, Bosnyak, Sanja, Magnani, Francesca, Robert E. Widdop, Charalampos G. Pappas (1327617), Susumu Ishiguro (735091), Vassiliki Magafa (1327629), Sanja Bosnyak (1327611), Tamura, Masaaki, Masaaki Tamura (735096), Magafa, Vassiliki, Tim Crook (1069)   +41 more
core   +1 more source

Effect of angiotensin receptor blockers and angiotensin converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in dogs with heart disease

Journal of Veterinary Internal Medicine, 2021
Background The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described alternative components, such as angiotensin ...
Éva Larouche‐Lebel, Kerry A. Loughran, Terry Huh, Mark A. Oyama   +3 more
doaj   +1 more source

Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]

, 2007
Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E., Kellems, Rodney E, Mi, TieJuan, Xia, Yang, Sun, C, Hewett, Peter W, Abbasi, S, Zhou, CC, Mi, T, Abbasi, Shahrzad, Hewett, Peter, Xia, Y, Sun, ChunXiao, Kellems, RE, Ahmed, Asif, Hewett, Peter W., Xia, L, Ahmad, Shakil, Xia, Lingwei, Zhou, Cissy Chenyi   +19 more
core   +1 more source

Renin-Angiotensin System: A Review of Historical Perspectives

Galician Medical Journal, 2023
The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova, Anna Zhuravlyova, Svitlana Ivanchenko   +2 more
doaj   +1 more source

Angiotensin-(1–7) reduces α-synuclein aggregation by enhancing autophagic activity in Parkinson’s disease

Neural Regeneration Research, 2022
Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson’s disease.
Qing Gao, Rui Chen, Liang Wu, Qing Huang, Xi-Xi Wang, You-Yong Tian, Ying-Dong Zhang   +6 more
doaj   +1 more source

Angiotensin-(1–7) exerts a protective action in a rat model of ventilator-induced diaphragmatic dysfunction

Intensive Care Medicine Experimental, 2019
Background Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin system is involved in diaphragmatic
Vanessa Zambelli, Anna Sigurtà, Laura Rizzi, Letizia Zucca, Paolo Delvecchio, Elena Bresciani, Antonio Torsello, Giacomo Bellani   +7 more
doaj   +1 more source

A New Perspective on the Renin-Angiotensin System

Diagnostics, 2022
Cardiovascular disease (CVD) is the leading cause of death in the world. Hypertension is a serious medical problem not only in adults but also in children and adolescents.
Adrian Martyniak, Przemysław J. Tomasik
doaj   +1 more source

Renal actions of angiotensin-(1-7)

Brazilian Journal of Medical and Biological Research, 1997
The heptapeptide angiotensin-(1-7) is considered to be a biologically active endproduct of the renin-angiotensin system. This angiotensin, which is devoid of the most known actions of angiotensin II such as induction of drinking behavior and ...
A.C. Simões-e-Silva, N.C.V. Baracho, K.T. Passaglio, R.A.S. Santos   +3 more
doaj   +1 more source

Does angiotensin-1 converting enzyme genotype influence motor or cognitive development after pre-term birth? [PDF]

, 2005
Background Raised activity of the renin-angiotensin system (RAS) may both amplify inflammatory and free radical responses and decrease tissue metabolic efficiency and thus enhance cerebral injury in the preterm infant.
Montgomery, H, Harding, DR, Devadason David, Humphries, S, Whitelaw, A, David Davedason, Marlow Neil, Montgomery Hugh E, Marlow, N, Hugh E Montgomery, Davedason, D, Andrew Whitelaw, Humphries, SE, Neil Marlow, Montgomery, HE, Whitelaw Andrew, Humphries Steve E, Dhamrait Sukhbir, Devadason, D, Dhamrait, S, Steve E Humphries, Harding David R, David R Harding, Sukhbir Dhamrait   +23 more
core   +1 more source

Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs

Cellular Physiology and Biochemistry, 2015
Background/Aims: Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) play important roles in inflammatory processes.
Bin Liang, Xin Wang, Nana Zhang, Huiyu Yang, Rui Bai, Ming Liu, Yunfei Bian, Chuanshi Xiao, Zhiming Yang   +8 more
doaj   +1 more source