Results 71 to 80 of about 34,611,245 (244)

Enhanced expression of Ang-(1-7) during pregnancy

Brazilian Journal of Medical and Biological Research, 2004
Pregnancy is a physiological condition characterized by a progressive increase of the different components of the renin-angiotensin system (RAS). The physiological consequences of the stimulated RAS in normal pregnancy are incompletely understood, and ...
Brosnihan K.B., Neves L.A.A., Anton L., Joyner J., Valdes G., Merrill D.C.   +5 more
doaj  

Novel Insights into the Cardioprotective Effects of the Peptides of the Counter-Regulatory Renin–Angiotensin System

Biomedicines
Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health.
Janette Alejandra Gamiño-Gutiérrez, Ivana María Terán-Hernández, Jairo Castellar-Lopez, Wendy Villamizar-Villamizar, Estefanie Osorio-Llanes, Mariali Palacios-Cruz, Wendy Rosales, Aileen Y. Chang, Luis Antonio Díaz-Ariza, María Clara Ospino, Evelyn Mendoza-Torres   +10 more
doaj   +1 more source

An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect

Clinics, 2011
INTRODUCTION AND OBJECTIVE: The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect
Rodrigo Araujo Fraga-Silva, Fabiana P. Costa-Fraga, Frederico B. De Sousa, Natalia Alenina, Michael Bader, Ruben D. Sinisterra, Robson A. S. Santos   +6 more
doaj   +1 more source

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

Modulation of the renin-angiotensin system against COVID-19: A path forward?

International Journal of Infectious Diseases
Soon after the pandemic outbreak in 2020, it was proposed that binding of SARS-CoV-2 to the angiotensin converting enzyme-2 may explain most of COVID-19’s manifestations.
Serge Camelo, Waly Dioh, J. Pedro Teixeira, Laurence W. Busse, Girish Nair, Gaëtan Plantefeve, Capucine Morelot-Panzini, Suzana Margareth Lobo, Wesley H. Self, Sean P. Collins, Rob Van Maanen, Stanislas Veillet   +11 more
doaj   +1 more source

Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension

Molecules, 2018
The renin-angiotensin-aldosterone system (RAAS) is a dominant player in several cardiovascular pathologies. This study investigated whether alterations induced by l-NAME, (NLG)-nitro-l-arginine methyl ester, a nitric oxide synthase inhibitor, and the ...
Fedor Simko, Tomas Baka, Kristina Krajcirovicova, Kristina Repova, Silvia Aziriova, Stefan Zorad, Marko Poglitsch, Michaela Adamcova, Russel J. Reiter, Ludovit Paulis   +9 more
doaj   +1 more source

A Review on Current Challenges and Knowledge Gaps in Artificial Stone Silicosis

American Journal of Industrial Medicine, EarlyView.
ABSTRACT Background The global emergence of artificial stone (AS) silicosis represents a critical occupational health challenge. The aim of this systematic review is to provide an overview of the clinical, functional, radiological, and occupational characteristics of patients affected by AS silicosis at the time of diagnosis, and to identify current ...
Paola Mason, Marco Biasioli, Filippo Liviero, Mariella Carrieri, Maria Luisa Scapellato, Vincenzo Baldo, Shivonne Prasad, Dunya Tomic, Ryan Hoy   +8 more
wiley   +1 more source

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

, 2009
The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization of these therapeutic peptides is an excellent way to render them more resistant against breakdown.
Walther, Thomas, de Vries, Louwe, Rink, Rick, Moll, Gert N., Kuipers, Anneke, Nelemans, S. Adriaan, Kluskens, Leon D., Meter-Arkema, Anita, Wang, Yong, Haas, Marijke   +9 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Peran Angiotensin 1-7 pada Penyakit Ginjal Kronik

Jurnal Ilmu Kesehatan Indonesia
Latar Belakang:  Penyakit ginjal kronik (PGK) ditandai penurunan progresif fungsi ginjal. Pada patogenesisnya, sistem renin–angiotensin–aldosteron (RAAS) berperan sentral.
Dinda Putri Sofiani, Harnavi Harun
doaj   +1 more source