Results 81 to 90 of about 34,611,245 (244)

DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]

, 2012
The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Eisenmenger, Wolfgang, Bondy, Brigitta, Mazza, Marianna, Zill, Peter, Clemens Früstück, Brigitta Bondy, Büttner, Andreas, Born, Christoph, Peter Zill, Andreas Büttner, Varallo-Bedarida, Gabriella, Cornelius Schüle, Früstück, Clemens, Rupprecht, Rainer, Möller, Hans-Jürgen, Schüle, Cornelius, Baghai, Thomas C., Wolfgang Eisenmenger, Christoph Born, Rainer Rupprecht, Hans-Jürgen Möller, Thomas C Baghai, Gabriella Varallo-Bedarida   +22 more
core   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source

Angiotensin-(1-7) is a modulator of the human renin-angiotensin system

, 1999
The renin-angiotensin system is important for cardiovascular homeostasis. Currently, therapies for different cardiovascular diseases are based on inhibition of angiotensin-converting enzyme (ACE) or angiotensin II receptor blockade.
van Gilst, WH, Buikema, H, de Zeeuw, D; id_orcid, Pinto, YM, Henning, RH, van Geel, PP, Roks, AJM   +6 more
core   +2 more sources

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Role of the vasodilator peptide angiotensin-(1–7) in cardiovascular drug therapy

, 2007
Christoph Schindler1, Peter Bramlage1, Wilhelm Kirch1, Carlos M Ferrario21Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany; 2Hypertension and Vascular Disease Center, Wake Forest University, School of
Carlos M Ferrario, Christoph Schindler, Wilhelm Kirch, Peter Bramlage   +3 more
core  

Reverse translation of phase I biomarker findings links the activity of angiotensin-(1–7) to repression of hypoxia inducible factor-1α in vascular sarcomas

BMC Cancer, 2012
Background In a phase I study of angiotensin-(1–7) [Ang-(1–7)], clinical benefit was associated with reduction in plasma placental growth factor (PlGF) concentrations. The current study examines Ang-(1–7) induced changes in biomarkers according to cancer
Petty W, Aklilu Mebea, Varela Victor A, Lovato James, Savage Paul D, Miller Antonius A   +5 more
doaj   +1 more source

Outcomes in Progressive Pulmonary Fibrosis in Systemic Autoimmune Rheumatic Diseases: Real‐World Data From the ILD‐PRO Registry

Arthritis &Rheumatology, EarlyView.
Objective We evaluated baseline characteristics, treatment patterns, and outcomes in patients with systemic autoimmune rheumatic disease–associated progressive pulmonary fibrosis (SARD‐PPF) and evaluated whether outcomes differed by SARD subtype. Methods The ILD‐PRO Registry is a prospective multicenter US registry of patients with PPF.
Sonali J. Bracken, Jeremy M. Weber, Megan L. Neely, Aparna C. Swaminathan, Scott M. Palmer, Erin M. Wilfong, Ann D. Chauffe, Elizabeth R. Volkmann   +7 more
wiley   +1 more source

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure [PDF]

, 2008
Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear.
Julian Thompson, Nicholas S Hopkinson, Anthony Kehoe, Hopkinson, NS, Humphries, SE, Mostafa Ghanei, Montgomery Hugh, Khoshbaten, A, Hopkinson Nicholas S, Soroush, MR, Hugh Montgomery, Thompson Julian, Hosseini-Khalili, AR, Steve E Humphries, Kehoe, A, Montgomery, H, Ghanei, M, Kehoe Anthony, Hosseini-khalili Ali, Khoshbaten A, A Khoshbaten, Mohammad Reza Soroush, Soroush Mohammad, Thompson, J, Humphries Steve E, Ghanei Mostafa, Ali Reza Hosseini-khalili   +26 more
core   +2 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Angiotensin‐converting enzyme 2 deficiency accelerates and angiotensin 1‐7 restores age‐related muscle weakness in mice

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background A pharmacologic strategy for age‐related muscle weakness is desired to improve mortality and disability in the elderly. Angiotensin‐converting enzyme 2 (ACE2) cleaves angiotensin II into angiotensin 1‐7, a peptide known to protect against ...
Hikari Takeshita, Koichi Yamamoto, Satoko Nozato, Masao Takeda, So‐ichiro Fukada, Tadakatsu Inagaki, Hirotsugu Tsuchimochi, Mikiyasu Shirai, Yoichi Nozato, Taku Fujimoto, Yuki Imaizumi, Serina Yokoyama, Motonori Nagasawa, Go Hamano, Kazuhiro Hongyo, Tatsuo Kawai, Hiroko Hanasaki‐Yamamoto, Shuko Takeda, Toshimasa Takahashi, Hiroshi Akasaka, Norihisa Itoh, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Hironori Nakagami, Hiromi Rakugi   +25 more
doaj   +1 more source