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Intranasal liposomal angiotensin-(1-7) administration reduces inflammation and viral load in the lungs during SARS-CoV-2 infection in K18-hACE2 transgenic mice. [PDF]

Antimicrob Agents Chemother
Mendes S, Guimarães LC, Costa PAC, Fernandez CC, Figueiredo MM, Teixeira MM, Dos Santos RAS, Guimarães PPG, Frézard F.   +8 more
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Angiotensin-(1-7) : a member of circulating angiotensin peptides

, 1992
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Angiotensin-(1–7): an update

Regulatory Peptides, 2000
The renin-angiotensin system is a major physiological regulator of arterial pressure and hydro-electrolyte balance. Evidence has now been accumulated that in addition to angiotensin (Ang) II other Ang peptides [Ang III, Ang IV and Ang-(1-7)], formed in the limited proteolysis processing of angiotensinogen, are importantly involved in mediating several ...
R A, Santos, M J, Campagnole-Santos, S P, Andrade   +2 more
openaire   +2 more sources

Angiotensin-(1–7) and the renin–angiotensin system

Current Opinion in Nephrology and Hypertension, 2007
In this review we will focus on the recent findings related to angiotensin-(1-7) as an angiotensin II counter-regulatory peptide within the renin-angiotensin system.The identification of the angiotensin-converting enzyme homologue ACE2 as an angiotensin peptide processing enzyme and of Mas as a receptor for angiotensin-(1-7) has contributed to ...
Robson A S, Santos, Anderson J, Ferreira
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Angiotensin (1-7) and other Angiotensin Peptides

Current Pharmaceutical Design, 2013
In the classical renin angiotensin system (RAS), angiotensin II Ang IIplays many important roles in cardiovascular disease and in kidney, brain, and other organs via the Ang II type 1 receptor (AT1). The RAS consists of many angiotensin peptides, including Ang (1-7), Ang (1-9), Ang (2-8), and Ang IV. Ang (1-7), produced by angiotensin-converting enzyme
Mitsuru, Ohishi, Koichi, Yamamoto, Hiromi, Rakugi   +2 more
openaire   +2 more sources

Angiotensin-(1–7) in the ovine fetus

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2001
In the adult animal, ANG-(1–7) may counterbalance some effects of ANG II. Its effects in the fetus are unknown. Basal ANG-(1–7), ANG I, ANG II, and renin concentrations were measured in plasma from ovine fetuses and their mothers ( n = 10) at 111 days of gestation.
Moritz, KM, Campbell, DJ, Wintour, EM
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Cardiovascular actions of angiotensin(1–7)

Peptides, 1993
Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +/- 1 mmHg) and the duration (range:
I F, Benter, D I, Diz, C M, Ferrario
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Angiotensin-(1-7), Adipokines and Inflammation

Metabolism, 2019
Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of ...
Deborah de Farias, Lelis, Daniela Fernanda de, Freitas, Amanda Souto, Machado, Thaísa Soares, Crespo, Sérgio Henrique Sousa, Santos   +4 more
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Counterregulatory Actions of Angiotensin-(1-7)

Hypertension, 1997
AbstractAngiotensin (Ang)-(1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. The first actions described for Ang-(1-7) indicated that the peptide mimicked some of the effects of Ang II, including the release of prostanoids and vasopressin.
C M, Ferrario, M C, Chappell, E A, Tallant, K B, Brosnihan, D I, Diz   +4 more
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Angiotensin-[1-7]

Journal of Cardiovascular Pharmacology, 1990
Structure-activity studies of angiotensin II (Ang II) have clearly established that the carboxyl-terminal phenylalanine is crucial for activation of angiotensin receptors associated with a broad range of effects including vasoconstriction, aldosterone release, and dipsogenesis. Thus, the heptapeptide angiotensin-[1-7] (Ang-[1-7]) has been classified as
M T, Schiavone, M C, Khosla, C M, Ferrario   +2 more
openaire   +2 more sources