Results 251 to 260 of about 34,610,957 (287)

Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors

Brain Research Bulletin, 1994
In this study we describe a new angiotensin antagonist [Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, (A-779)] selective for the heptapeptide angiotensin-(1-7) [Ang-(1-7)]. A-779 blocked the antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral ...
Robson A.S. Santos, Maria J. Campagnole-Santos, Nilo C.V. Baracho, Marco A.P. Fontes, Luciana C.S. Silva, Liomar A.A. Neves, Djenane R. Oliveira, Sordaine M. Caligiorne, Andre R.V. Rodrigues, Carlos Gropen, Wania S. Carvalho, Ana C.Simoes E Silva, Mahesh C. Khosla   +12 more
openaire   +2 more sources

Angiotensin-(1–7): a bioactive fragment of the renin–angiotensin system

Regulatory Peptides, 1998
Accumulating evidence suggests that angiotensin-(1-7) [Ang-(1-7)] is an important component of the renin-angiotensin system. As the most pleiotropic metabolite of angiotensin I (Ang I) it manifest actions which are most often the opposite of those described for angiotensin II (Ang II).
C M, Ferrario, S N, Iyer
openaire   +2 more sources

Angiotensin-(1-7)

European Journal of Pharmacology, 2008
Therapeutic modulation of the renin-angiotensin system is not complete without taking into consideration the beneficial effects of angiotensin-(1-7) in cardiovascular pathology. Various pharmacological pathways are already exploited to involve this heptapeptide in therapy as both inhibitors of angiotensin-converting enzyme and angiotensin II type 1 ...
Iusuf, Dilek, Henning, Robert H., van Gilst, Wiek H., Roks, Anton J. M.   +3 more
openaire   +1 more source

Angiotensin-(1-7): a new hormone of the angiotensin system.

Hypertension, 1991
We provide a new foundation for an alternative interpretation of the biochemical physiology of the brain and other tissue angiotensin systems on the basis of research done in our laboratory. This perspective is prompted by the discovery that angiotensin-(1-7) has cellular functions that differ from those established for angiotensin II.
C M, Ferrario, K B, Brosnihan, D I, Diz, N, Jaiswal, M C, Khosla, A, Milsted, E A, Tallant   +6 more
openaire   +2 more sources

Angiotensin 1-7 and Inflammation

2019
Ang-(1-7) binds to the G-protein-coupled MAS receptor and exerts many beneficial actions in the context of acute inflammation. Ang-(1-7) reduces production and expression of many cytokines and adhesion molecules and decreases leukocyte movement in vitro and in vivo.
Izabela Galvão, Flavia Rago, Isabella Zaidan Moreira, Mauro Martins Teixeira   +3 more
openaire   +1 more source

Angiotensin(1–7) in the spontaneously hypertensive rat

Peptides, 1993
We profiled the concentrations of angiotensin I (Ang I), angiotensin II (Ang II), and angiotensin(1-7) [Ang(1-7)] by the combination of radioimmunoassay and high performance liquid chromatography in the blood of 14-week-old male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) drinking either tap water or a solution containing ceranapril ...
K, Kohara, K B, Brosnihan, C M, Ferrario
openaire   +2 more sources

Angiotensin-(1-7) and the Heart

2019
An underpinning of our current evolving concepts on the contributions of angiotensin peptides to cardiovascular disease resides in the discovery of biological actions of angiotensin-(1-7) as an intrinsic endogenous biotransformation factor counteracting angiotensin II actions.
Carlos M. Ferrario, Che Ping Cheng, Jasmina Varagic   +2 more
openaire   +1 more source

Angiotensin-(1-7) as an antihypertensive, antifibrotic target

Current Hypertension Reports, 2008
Over the past two decades, enormous progress has been made in understanding the possible physiological significance of alternate renin-angiotensin system processing pathways and angiotensin fragments, such as angiotensin (Ang)-(1-7). Evidence from in vivo and ex vivo studies in humans and various animal models suggests a possible role for this ...
Michael J, Katovich, Justin L, Grobe, Mohan K, Raizada   +2 more
openaire   +2 more sources

[Angiotensin (1-7) receptor].

Nihon rinsho. Japanese journal of clinical medicine, 2009
Mas, which was protooncogene, first detected in vivo by tumorigenic properties originating from rearrangement of its 5'-flanking region was identified as a functional receptor for angiotensin (1-7) and provide a clear molecular basis for the physiological actions of this biologically active peptide. Angiotensin (1-7) is mainly produced from angiotensin
Mitsuru, Ohishi, Hiromi, Rakugi
openaire   +1 more source

Angiotensin II/Angiotensin-(1–7)

2013
Patricia E. Gallagher, Alison L. Arter, Bhavani Krishnan, Maria A. Garcia-Espinosa, E. Ann Tallant   +4 more
openaire   +1 more source