Results 261 to 270 of about 311,335 (299)

Cardiovascular actions of angiotensin(1–7)

Peptides, 1993
Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +/- 1 mmHg) and the duration (range:
I F, Benter, D I, Diz, C M, Ferrario
openaire   +2 more sources

Counterregulatory Actions of Angiotensin-(1-7)

Hypertension, 1997
AbstractAngiotensin (Ang)-(1-7) is a bioactive component of the renin-angiotensin system that is formed endogenously from either Ang I or Ang II. The first actions described for Ang-(1-7) indicated that the peptide mimicked some of the effects of Ang II, including the release of prostanoids and vasopressin.
C M, Ferrario, M C, Chappell, E A, Tallant, K B, Brosnihan, D I, Diz   +4 more
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Angiotensin-(1-7), Adipokines and Inflammation

Metabolism, 2019
Nowadays the adipose tissue is recognized as one of the most critical endocrine organs releasing many adipokines that regulate metabolism, inflammation and body homeostasis. There are several described adipokines, including the renin-angiotensin system (RAS) components that are especially activated in some diseases with increased production of ...
Deborah de Farias, Lelis, Daniela Fernanda de, Freitas, Amanda Souto, Machado, Thaísa Soares, Crespo, Sérgio Henrique Sousa, Santos   +4 more
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Angiotensin-[1-7]

Journal of Cardiovascular Pharmacology, 1990
Structure-activity studies of angiotensin II (Ang II) have clearly established that the carboxyl-terminal phenylalanine is crucial for activation of angiotensin receptors associated with a broad range of effects including vasoconstriction, aldosterone release, and dipsogenesis. Thus, the heptapeptide angiotensin-[1-7] (Ang-[1-7]) has been classified as
M T, Schiavone, M C, Khosla, C M, Ferrario   +2 more
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Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors

Brain Research Bulletin, 1994
In this study we describe a new angiotensin antagonist [Asp1-Arg2-Val3-Tyr4-Ile5-His6-D-Ala7, (A-779)] selective for the heptapeptide angiotensin-(1-7) [Ang-(1-7)]. A-779 blocked the antidiuretic effect of Ang-(1-7) in water-loaded rats and the changes in blood pressure produced by Ang-(1-7) microinjection into the dorsal-medial and ventrolateral ...
Robson A.S. Santos, Maria J. Campagnole-Santos, Nilo C.V. Baracho, Marco A.P. Fontes, Luciana C.S. Silva, Liomar A.A. Neves, Djenane R. Oliveira, Sordaine M. Caligiorne, Andre R.V. Rodrigues, Carlos Gropen, Wania S. Carvalho, Ana C.Simoes E Silva, Mahesh C. Khosla   +12 more
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Angiotensin-(1–7): a bioactive fragment of the renin–angiotensin system

Regulatory Peptides, 1998
Accumulating evidence suggests that angiotensin-(1-7) [Ang-(1-7)] is an important component of the renin-angiotensin system. As the most pleiotropic metabolite of angiotensin I (Ang I) it manifest actions which are most often the opposite of those described for angiotensin II (Ang II).
C M, Ferrario, S N, Iyer
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Angiotensin-(1-7)

European Journal of Pharmacology, 2008
Therapeutic modulation of the renin-angiotensin system is not complete without taking into consideration the beneficial effects of angiotensin-(1-7) in cardiovascular pathology. Various pharmacological pathways are already exploited to involve this heptapeptide in therapy as both inhibitors of angiotensin-converting enzyme and angiotensin II type 1 ...
Iusuf, Dilek, Henning, Robert H., van Gilst, Wiek H., Roks, Anton J. M.   +3 more
openaire   +1 more source

Angiotensin-(1-7): a new hormone of the angiotensin system.

Hypertension, 1991
We provide a new foundation for an alternative interpretation of the biochemical physiology of the brain and other tissue angiotensin systems on the basis of research done in our laboratory. This perspective is prompted by the discovery that angiotensin-(1-7) has cellular functions that differ from those established for angiotensin II.
C M, Ferrario, K B, Brosnihan, D I, Diz, N, Jaiswal, M C, Khosla, A, Milsted, E A, Tallant   +6 more
openaire   +2 more sources

Angiotensin 1-7 and Inflammation

2019
Ang-(1-7) binds to the G-protein-coupled MAS receptor and exerts many beneficial actions in the context of acute inflammation. Ang-(1-7) reduces production and expression of many cytokines and adhesion molecules and decreases leukocyte movement in vitro and in vivo.
Izabela Galvão, Flavia Rago, Isabella Zaidan Moreira, Mauro Martins Teixeira   +3 more
openaire   +1 more source

Angiotensin(1–7) in the spontaneously hypertensive rat

Peptides, 1993
We profiled the concentrations of angiotensin I (Ang I), angiotensin II (Ang II), and angiotensin(1-7) [Ang(1-7)] by the combination of radioimmunoassay and high performance liquid chromatography in the blood of 14-week-old male Wistar-Kyoto (WKY) and spontaneously hypertensive rats (SHR) drinking either tap water or a solution containing ceranapril ...
K, Kohara, K B, Brosnihan, C M, Ferrario
openaire   +2 more sources