Angiotensin II modulates THP-1-like macrophage phenotype and inflammatory signatures via angiotensin II type 1 receptor [PDF]
Frontiers in Cardiovascular Medicine, 2023 Angiotensin II (Ang II) is a major component of the renin–angiotensin or renin–angiotensin–aldosterone system, which is the main element found to be involved in cardiopathology.
Tlili Barhoumi +7 more
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Advances in the allostery of angiotensin II type 1 receptor [PDF]
Cell & Bioscience, 2023 Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high ...
Xi Zhang +4 more
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Candesartan inhibits inflammation through an angiotensin II type 1 receptor independent way in human embryonic kidney epithelial cells [PDF]
Anais da Academia Brasileira de Ciências, 2019 : Besides stimulating vasoconstriction, Angiotensin II is also well known in inducing reactive oxygen species and promoting inflammatory phenotype switch via its type 1 receptor.
YING YU +7 more
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Role of agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) in pathogenesis of preeclampsia. [PDF]
Glob Med GenetWang J +5 more
europepmc +2 more sources
Validation of six commercially available angiotensin II type 1 receptor antibodies [PDF]
Acta Biochimica et Biophysica SinicaLi Bingjie +5 more
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Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis [PDF]
Kidney Research and Clinical Practice, 2023 Background Angiotensin II induces glomerular and podocyte injury via systemic and local vasoconstrictive or non-hemodynamic effects including oxidative stress. The release of reactive oxygen species (ROS) from podocytes may participate in the development
Tae-Sun Ha +3 more
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Biomedicines, 2023 The present study examined the underlying mechanisms of mechanical allodynia and thermal hyperalgesia induced by the intracisternal injection of angiotensin (Ang) II.
Ki-Don Park +8 more
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Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?
Molecular Medicine, 2020 Infection of lung cells by the corona virus results in a loss of the balance between, on the one hand, angiotensin II-mediated stimulation of the angiotensin II type 1 receptor and, on the other hand, stimulation of the angiotensin II type 2 receptor and/
Pawel Namsolleck, Gert N. Moll
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Therapeutic targets in the brain for overactive bladder: A focus on angiotensin II type 1 receptor
Journal of Pharmacological Sciences, 2023 Overactive bladder is a condition that affects both men and women, and significantly affects patients' quality of life. Anticholinergics, β3-adrenoceptor agonists, and botulinum toxin are currently being used for treatment.
Shogo Shimizu
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki +12 more
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