Possible benefits of azilsartan compared with other angiotensin II type 1 receptor blockers [PDF]
Hypertension Research, 2014 Possible benefits of azilsartan compared with other angiotensin II type 1 receptor ...
Shin-ichiro Miura, Keijiro Saku
semanticscholar +4 more sources
Perioperative angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers for preventing mortality and morbidity in adults. [PDF]
Cochrane Database Syst Rev, 2016 Zou Z +6 more
europepmc +4 more sources
Angiotensin II Type 1 Receptor Blockers [PDF]
Circulation, 2001 In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
M. Burnier
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Review: Angiotensin II type 1 receptor blockers: class effects versus molecular effects [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2010 Highly selective angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are now available. The AT1receptor is a member of the G protein-coupled receptor (GPCR) superfamily and block the diverse effects of Ang II. Several ARBs are available for clinical use.
Shin-ichiro, Miura +2 more
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Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor [PDF]
Molecular Pharmacology, 2015 Ligand-independent signaling by the angiotensin II type 1 receptor (AT1R) can be activated in clinical settings by mechanical stretch and autoantibodies as well as receptor mutations. Transition of the AT1R to the activated state is known to lower inverse agonistic efficacy of clinically used AT1R blockers (ARBs).
NODE, Koichi +3 more
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Angiotensin II Type 1 Receptor Blockers and Congestive Heart Failure [PDF]
Circulation, 2001 To the Editor: We read with great interest the review on angiotensin II type 1 receptor blockers by Michel Burnier.1 He quotes previous investigations, including the results of the Losartan Heart Failure Survival Study (ELITE II)2 and states that “…losartan was not superior to captopril in reducing morbidity and mortality…,” and concludes that ...
Johann W. Auer +2 more
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Do all angiotensin II type 1 receptor blockers have the same beneficial effects? [PDF]
British Journal of Pharmacology, 2007 Angiotensin II type 1 (AT1) receptor blockers (ARBs) are highly selective for the AT1 receptor, which is a member of the G protein‐coupled receptor superfamily (GPCRs), and block the diverse effects (hypertension, hypertrophy, heart failure, proteinuria etc.) of angiotensin II. Many ARBs are in clinical use and have been shown to be safe and effective.
Shin‐ichiro Miura, Keijiro Saku
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Clinical pharmacogenetics of angiotensin II receptor blockers in Iraq
Journal of Pharmacy and Bioallied Sciences, 2023 Background: Clinical pharmacogenetics is a rapidly growing field that focuses on the study of genetic variations and their impact on drug metabolism, efficacy, and safety. Angiotensin II receptor blockers (ARBs) are commonly used to treat hypertension in
Hany A Al-Hussaniy +5 more
doaj +2 more sources
Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats [PDF]
Hypertension Research, 2009 Angiotensin II receptor blockers (ARBs) vary in their binding affinities to angiotensin II type 1 (AT(1)) receptors in in vitro experiments. We compared a high-affinity ARB, olmesartan, and a low-affinity ARB, valsartan, in terms of their vascular protective effects in stroke-prone spontaneously hypertensive rats (SHR-SP).
Shinji Takai +4 more
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Angiotensin II Type 1 Receptor Blockers [PDF]
Value in Health, 2018 L Luan, H Hu, SC Li
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