Results 11 to 20 of about 77,701 (209)

The angiotensin II type 1 receptor blocker valsartan in the battle against COVID‐19 [PDF]

Obesity, 2021
AbstractObjectiveSevere acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) uses the host’s angiotensin‐converting enzyme 2 (ACE2) as a cellular entry point. Therefore, modulating ACE2 might impact SARS‐CoV‐2 viral replication, shedding, and coronavirus disease 2019 (COVID‐19) severity.
Marlies de Ligt, Matthijs K. C. Hesselink, Johanna Jorgensen, Johan W. E. Jocken, Ellen E. Blaak, Gijs H. Goossens   +5 more
openaire   +3 more sources

Angiotensin II Type 1 Receptor Blockers and Congestive Heart Failure [PDF]

Circulation, 2001
To the Editor: We read with great interest the review on angiotensin II type 1 receptor blockers by Michel Burnier.1 He quotes previous investigations, including the results of the Losartan Heart Failure Survival Study (ELITE II)2 and states that “…losartan was not superior to captopril in reducing morbidity and mortality…,” and concludes that ...
Johann W. Auer, Robert Berent, Bernd Eber   +2 more
openaire   +1 more source

Angiotensin II Type I Receptor (AT1R): The Gate towards COVID-19-Associated Diseases

Molecules, 2022
The binding of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein to its cellular receptor, the angiotensin-converting enzyme 2 (ACE2), causes its downregulation, which subsequently leads to the dysregulation of the renin–
George El-Arif, Shaymaa Khazaal, Antonella Farhat, Julien Harb, Cédric Annweiler, Yingliang Wu, Zhijian Cao, Hervé Kovacic, Ziad Abi Khattar, Ziad Fajloun, Jean-Marc Sabatier   +10 more
doaj   +1 more source

Angiotensin Receptor Blocker Protection Against Podocyte-Induced Sclerosis Is Podocyte Angiotensin II Type 1 Receptor-Independent [PDF]

Hypertension, 2010
In the present study, we tested the hypothesis that the renoprotective effect of an angiotensin receptor blocker depends on the angiotensin II type 1 (AT 1 ) receptor on podocytes. For this purpose, we generated podocyte-specific knockout mice for the AT 1 gene ( Agtr1a
Taiji, Matsusaka, Takako, Asano, Fumio, Niimura, Masaru, Kinomura, Akihiro, Shimizu, Ayumi, Shintani, Ira, Pastan, Agnes B, Fogo, Iekuni, Ichikawa   +8 more
openaire   +2 more sources

The fourth-generation Calcium channel blocker: Cilnidipine

Indian Heart Journal, 2013
Several classes of antihypertensive agents have been in clinical use, including diuretics, α-blockers, β-blockers, angiotensin converting enzyme (ACE) inhibitors, angiotensin II type 1 receptor blockers (ARB), and organic calcium channel blockers (CCBs).
K. Sarat Chandra, G. Ramesh
doaj   +1 more source

Angiotensin II Type 1 Receptor Blockers [PDF]

Circulation, 2001
In the 1970s, a series of observations demonstrated that angiotensin II has deleterious effects on the heart and kidney and that patients with high levels of plasma renin activity are at a higher risk of developing stroke or myocardial infarction than those with low plasma renin activity.1 2 Thereafter, the development of pharmacological probes that ...
openaire   +2 more sources

Angiotensin II type 1 receptor blocker attenuates diabetes-induced atrial structural remodeling [PDF]

Journal of Cardiology, 2011
Diabetes mellitus promotes atrial structural remodeling, thereby producing atrial arrhythmogenicity, where advanced glycation endproducts (AGEs) and their receptor (RAGE) are implicated to play a role in the pathogenesis.We investigated the effects of candesartan, an angiotensin type II receptor blocker, on the diabetes-induced atrial structural change.
Kato, Takeshi, Yamashita, Takeshi, Sekiguchi, Akiko, Tsuneda, Takayuki, Sagara, Kouichi, Takamura, Masayuki, Kaneko, Shuichi, Aizawa, Tadanori, Fu, Long-Tai   +8 more
openaire   +2 more sources

Hypertension: Renin-Angiotensin-Aldosterone System Alterations [PDF]

, 2015
Blockers of the renin-angiotensin-aldosterone system (RAAS), that is, renin inhibitors, angiotensin (Ang)-converting enzyme (ACE) inhibitors, Ang II type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the ...
Danser, A.H.J. (Jan), Esch, J.H.M. (Joep) van, Meiracker, A.H. (Anton) van den, Riet, L. (Luuk) te, Roks, A.J.M. (Anton)   +4 more
core   +1 more source

Angiotensin II type 1 receptor blocker inhibits fibrosis in rat nonalcoholic steatohepatitis [PDF]

Hepatology, 2007
Nonalcoholic steatohepatitis (NASH) is now the most frequent cause of chronic liver impairment in developed countries and is a suggested causative factor in the development of cryptogenic cirrhosis and hepatocellular carcinoma.
Akira, Hirose, Masafumi, Ono, Toshiji, Saibara, Yasuko, Nozaki, Kosei, Masuda, Akemi, Yoshioka, Masaya, Takahashi, Naoaki, Akisawa, Shinji, Iwasaki, Jude A, Oben, Saburo, Onishi   +10 more
openaire   +2 more sources

Drug treatment of hypertension: focus on vascular health [PDF]

, 2016
Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C., Lang, Ninian N., Touyz, Rhian M.   +2 more
core   +1 more source