International Journal of Infectious Diseases, 2020 ACE2 is a receptor of entry of SARS-CoV-2 into the host cells, and its upregulation has been implicated in increasing susceptibility of individuals to this infection.
Ashwini Shete
doaj +1 more source
An update of medical care in Marfan syndrome
Tzu Chi Medical Journal, 2022 Marfan syndrome (MFS), a multisystemic connective disorder, caused by fibrillin 1 gene mutations with autosomal dominant inheritance. The disease spectrum is wide and the major causes of death are related to aortic root aneurysm or dissection.
Hsin-Hui Chiu
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Angiotensin II type 1 receptor blocker-induced immune thrombocytopenia: a case report [PDF]
Journal of Medical Case Reports, 2013 The development of thrombocytopenia after a dose increase in losartan and subsequently after switching the patient to valsartan is reported.A 61-year-old Caucasian man presented with epistaxis and gingival bleeding of three weeks duration. Laboratory evaluation revealed a hemoglobin level of 144g/L, a leukocyte count of 16.2×109 cells/L (72.51 ...
Patel, Dhiren K. +2 more
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Angiotensin II blockade and aortic-root dilation in Marfan's syndrome [PDF]
, 2008 Background: Progressive enlargement of the aortic root, leading to dissection, is the main cause of premature death in patients with Marfan's syndrome. Recent data from mouse models of Marfan's syndrome suggest that aortic-root enlargement is caused by ...
Brooke, Benjamin S. +5 more
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Review: Angiotensin II type 1 receptor blockers: class effects versus molecular effects [PDF]
Journal of the Renin-Angiotensin-Aldosterone System, 2010 Highly selective angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are now available. The AT1receptor is a member of the G protein-coupled receptor (GPCR) superfamily and block the diverse effects of Ang II. Several ARBs are available for clinical use.
Shin-ichiro, Miura +2 more
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Clinical pharmacogenetics of angiotensin II receptor blockers in Iraq
Journal of Pharmacy and Bioallied Sciences, 2023 Background: Clinical pharmacogenetics is a rapidly growing field that focuses on the study of genetic variations and their impact on drug metabolism, efficacy, and safety. Angiotensin II receptor blockers (ARBs) are commonly used to treat hypertension in
Hany A Al-Hussaniy +5 more
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Structure-Function Basis of Attenuated Inverse Agonism of Angiotensin II Type 1 Receptor Blockers for Active-State Angiotensin II Type 1 Receptor [PDF]
Molecular Pharmacology, 2015 Ligand-independent signaling by the angiotensin II type 1 receptor (AT1R) can be activated in clinical settings by mechanical stretch and autoantibodies as well as receptor mutations. Transition of the AT1R to the activated state is known to lower inverse agonistic efficacy of clinically used AT1R blockers (ARBs).
NODE, Koichi +3 more
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Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]
, 2004 <p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C. +5 more
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A review of the molecular mechanisms underlying the development and progression of cardiac remodeling [PDF]
, 2017 Pathological molecular mechanisms involved in myocardial remodeling contribute to alter the existing structure of the heart, leading to cardiac dysfunction.
Angelini, Francesco +15 more
core +6 more sources
Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers. [PDF]
PLoS ONE, 2013 While the molecular structures of angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) are very similar, they are also slightly different. Although each ARB has been shown to exhibit a unique mode of binding to AT1 receptor, different positions ...
Shin-Ichiro Miura +5 more
doaj +1 more source