Results 111 to 120 of about 8,783 (159)
, 2015 From schizophrenia to asthma, GPCRs have an important role in drug therapy. This work focuses on the AT1R; a GPCR with widespread use in the treatment of cardiovascular disease. Specifically, this work examines the structural aspects of AT1R dimerization,
Young, Brent M.
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Angiotensin II type 1 receptor (AGTR1) [PDF]
Science-Business eXchange, 2011 openaire +3 more sources
Validation of six commercially available angiotensin II type 1 receptor antibodies
Acta Biochimica et Biophysica SinicaLi Bingjie +5 more
doaj +1 more source
Hypertension, 2012 The renin-angiotensin system regulates cardiovascular physiology via angiotensin II engaging the angiotensin type 1 or type 2 receptors. Classic actions are type 1 receptor mediated, whereas the type 2 receptor may counteract type 1 receptor activity ...
Mónica Flores-Muñoz +2 more
exaly +2 more sources
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Arresting angiotensin type 1 receptors
Trends in Endocrinology and Metabolism, 2003The type 1 angiotensin (AT(1)) receptor mediates the homeostatic and pathological actions of the peptide hormone, angiotensin II. With regard to the processes that activate and deactivate seven-transmembrane-spanning, G-protein-coupled receptors (GPCRs), AT(1) receptors are among the most widely studied, serving as prototypes for GPCRs that bind and ...
Thomas, Walter G., Qian, Hongwei
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Angiotensin (1???7) is an antagonist at the type 1 angiotensin II receptor
Journal of Hypertension, 1994The present study investigated the antagonism of the amino-terminal heptapeptide fragment of angiotensin II ([des-Phe8]-angiotensin II; Ang(1-7)) to angiotensin II (Ang II) both in vitro in rabbit aortae and in vivo in rats.In rabbit isolated endothelium intact aortic rings Ang(1-7) caused a concentration-related rightward displacement of the Ang II ...
J M, Mahon +3 more
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Regulation of Vascular Type 1 Angiotensin Receptors by Cytokines
Hypertension, 1997AbstractAlthough various cytokines are known to be expressed in atherosclerotic lesions, it is not known how these cytokines affect receptors for the peptide hormone angiotensin II (Ang II). We therefore examined the effects of interleukin-1α (220 U/mL [10 ng/mL]), tumor necrosis factor-α (280 U/mL [100 ng/mL]), and interferon gamma (100 U/mL) on Ang ...
H, Sasamura +5 more
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Inhibiting angiotensin type 1 receptors as a target for diabetes
Expert Opinion on Therapeutic Targets, 2008Angiotensin type 1 (AT1) receptor blockers (ARBs) are used to treat hypertension and related end-organ damage. ARBs have been recognised as regulators of glucose- and lipid metabolism. Clinical trials demonstrated that AT1 receptor antagonism lowers the risk for type 2 diabetes compared with other antihypertensive therapies.
Ulrich, Kintscher +2 more
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Biased Agonism of the Angiotensin II Type 1 Receptor
Mini-Reviews in Medicinal Chemistry, 2012G protein-coupled receptors (GPCRs) can be activated by multiple ligands and exhibit the capacity to couple to numerous intracellular signal transduction pathways. This property allows GPCRs to be modulated by biased agonists that selectively activate specific subsets of GPCR-regulated cellular signaling proteins.
C M, Godin, S S G, Ferguson
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Type 1 angiotensin II receptors of adrenal tumors
Steroids, 1995The present study was designed to clarify the transcriptional regulation of the human type 1 angiotensin II receptor (AT1) gene and its pathophysiological roles in steroidogenesis by adrenal tumors. A cDNA encoding type 1 angiotensin II receptor (AT1) was isolated from a human liver cDNA library encoding a protein of 359 amino acids with seven ...
H, Nawata +8 more
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