Results 91 to 100 of about 8,783 (159)

Inhibition of Rho kinase mediates the neuroprotective effects of estrogen in the MPTP model of Parkinson's disease

Neurobiology of Disease, 2013
The mechanism by which estrogen protects dopaminergic neurons has not yet been clarified. It is not known if changes in RhoA/Rho kinase activity are involved in the enhanced vulnerability of dopaminergic neurons observed after estrogen depletion.
Ana I. Rodriguez-Perez, Antonio Dominguez-Meijide, Jose L. Lanciego, Maria J. Guerra, Jose L. Labandeira-Garcia   +4 more
doaj   +1 more source

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

, 2009
Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I ...
Corrêa, Silvana Aparecida Alves [UNIFESP], Nogueira-de-Souza, Naiara Corrêa [UNIFESP], Noronha, Samuel Marcos Ribeiro de [UNIFESP], Costa, Ana Maria Massad [UNIFESP], Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP], Carvalho, Cristina Valletta de [UNIFESP], Gomes, Mariano Tamura Vieira [UNIFESP], Linhares, Jose Juvenal [UNIFESP]   +7 more
core   +1 more source

Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation

PPAR Research, 2019
Rosiglitazone (RGZ), a peroxisome proliferator-activated receptor gamma (PPARγ) ligand, has been reported to act as insulin sensitizer and exert cardiovascular actions.
María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza   +8 more
doaj   +1 more source

Imidazole-Based AT₁ Receptor Ligands: Design, Synthesis and Pharmacological Evaluation

Molecules
The angiotensin II type 1 (AT1) receptor is a key component of the renin–angiotensin system (RAS) and a validated target for cardiovascular and renal disorders. Developing small molecules with defined AT1 versus AT2 binding profiles remains important for
Florian Descamps, Marouane Rami, Jean-François Goossens, Patricia Melnyk, Maxime Liberelle, Saïd Yous   +5 more
doaj   +1 more source

Angiotensin II type 1 receptor expression in human breast tissues

, 1997
We demonstrate the expression of angiotensin II type 1 (AT1) receptors in normal and diseased human breast tissues. Using monoclonal antibody 6313/G2, directed against a specific sequence in the extracellular domain of the AT1 receptor ...
INWANG ER, GOODE AW, HO MM, PAYNE JG, BROWN CL, VINSON GP, PUDDEFOOT JR, MARSIGLIANTE, Santo   +7 more
core   +1 more source

Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research

Reviews in Cardiovascular Medicine
An estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj   +1 more source

Interaction of angiotensin II with the angiotensin type 2 receptor inhibits the cardiac transient outward potassium current

, 2004
Objective: The Ca2+ -independent transient outward K+ current (Ito) plays a crucial role in shaping the cardiac action potential. In the present study, we examined whether angiotensin II (AngII) regulated the Ito as well as the putative intracellular ...
Tamargo Menéndez, Juan, Arias, Cristina, Valenzuela, Carmen, Guizy, Miriam, Delpón Mosquera, María Eva, Moreno, Fernández, Ignacio, González, Teresa, Caballero Collado, Ricardo, Gómez García, Ricardo, Núñez Fernández, Lucía   +9 more
core   +1 more source

The angiotensin II receptors type 1 and 2 modulate astrocytes and their crosstalk with microglia and neurons in an in vitro model of ischemic stroke

BMC Neuroscience
Background Astrocytes are the most abundant cell type of the central nervous system and are fundamentally involved in homeostasis, neuroprotection, and synaptic plasticity.
Daniel Navin Olschewski, Nilufar Nazarzadeh, Felix Lange, Anna Maria Koenig, Christina Kulka, Jella-Andrea Abraham, Stefan Johannes Blaschke, Rudolf Merkel, Bernd Hoffmann, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger, Sabine Ulrike Vay   +12 more
doaj   +1 more source

Participação de receptores angiotensinérgicos na ingestão de água induzida pela injeção intracerebroventricular de serotonina e angiotensina em pombos (Columba livia) / [PDF]

, 1999
Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências ...
Brun, Sandra Regina Martini
core  

Osteoprotegerin: a pancreatic islets dysfunction and vascular injury modulator

, 2011
Background. Osteoprotegerin (OPG) is a soluble glycoprotein of the tumor necrosis factor (TNF) receptor superfamily, which was initially identified as a key regulator in bone turnover.
Toffoli, Barbara
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