Results 81 to 90 of about 35,659,151 (163)

Imidazole-Based AT₁ Receptor Ligands: Design, Synthesis and Pharmacological Evaluation

Molecules
The angiotensin II type 1 (AT1) receptor is a key component of the renin–angiotensin system (RAS) and a validated target for cardiovascular and renal disorders. Developing small molecules with defined AT1 versus AT2 binding profiles remains important for
Florian Descamps, Marouane Rami, Jean-François Goossens, Patricia Melnyk, Maxime Liberelle, Saïd Yous   +5 more
doaj   +1 more source

Angiotensin Type 1 Receptor-Dependent Internalization of SARS-CoV-2 by Angiotensin-Converting Enzyme 2. [PDF]

Hypertension, 2021
Ogunlade BO, Lazartigues E, Filipeanu CM.   +2 more
europepmc   +1 more source

Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures. [PDF]

Antioxidants (Basel), 2022
Quijano A, Diaz-Ruiz C, Lopez-Lopez A, Villar-Cheda B, Muñoz A, Rodriguez-Perez AI, Labandeira-Garcia JL.   +6 more
europepmc   +1 more source

The angiotensin II receptors type 1 and 2 modulate astrocytes and their crosstalk with microglia and neurons in an in vitro model of ischemic stroke

BMC Neuroscience
Background Astrocytes are the most abundant cell type of the central nervous system and are fundamentally involved in homeostasis, neuroprotection, and synaptic plasticity.
Daniel Navin Olschewski, Nilufar Nazarzadeh, Felix Lange, Anna Maria Koenig, Christina Kulka, Jella-Andrea Abraham, Stefan Johannes Blaschke, Rudolf Merkel, Bernd Hoffmann, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger, Sabine Ulrike Vay   +12 more
doaj   +1 more source

Novel Antihypertensive Medications to Target the Renin-Angiotensin System: Mechanisms and Research

Reviews in Cardiovascular Medicine
An estimated 1.28 billion individuals in the global population suffer from hypertension. Importantly, uncontrolled hypertension is strongly linked to various cardiovascular and cerebrovascular diseases.
Zhe Jiang, Changlin Zhai, Guanmin Tang
doaj   +1 more source

Angiotensin II Type 2 Receptor Antagonizes Angiotensin II Type 1 Receptor-Mediated Cardiomyocyte Autophagy

, 2009
Autophagy has emerged as an important process in the pathogenesis of cardiovascular diseases, but the proximal triggers for autophagy are unknown. Angiotensin II plays a central role in the pathogenesis of cardiac hypertrophy and heart failure.
Delbridge, Lea M. D., Harrap, Stephen B., D'Amore, Angelo, Curl, Claire L., Thomas, Walter G., Porrello, Enzo R., Allen, Andrew M.   +6 more
core   +1 more source

Therapeutic Assessment of Combination Therapy with a Neprilysin Inhibitor and Angiotensin Type 1 Receptor Antagonist on Angiotensin II-Induced Atherosclerosis, Abdominal Aortic Aneurysms, and Hypertension. [PDF]

J Pharmacol Exp Ther, 2021
AlSiraj Y, Thatcher SE, Liang CL, Ali H, Ensor M, Cassis LA.   +5 more
europepmc   +1 more source

Effect of angiotensin II receptor blocker on TGF-β1, MMP-1, and collagen type I and type III concentration in New Zealand rabbit urethral stricture model

, 2018
Safendra Siregar, Reni Farenia, Suwandi Sugandi, Rully M Roesli Urology Division, Department of Surgery, Hasan Sadikin Hospital Bandung, Faculty of Medicine Padjadjaran University, Bandung, Indonesia Introduction: Urethral stricture is a disease with a ...
Roesli RM, Sugandi S, Siregar S, Farenia R   +3 more
core  

Association between the angiotensin-converting enzyme (insertion/deletion) and angiotensin II type 1 receptor (A1166C) polymorphisms and breast cancer among Brazilian women

, 2009
Introduction. We evaluated the assocation between components of the renin-angiotensin system and the development of breast cancer in a case-control study by means of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) and angiotensin II type I ...
Corrêa, Silvana Aparecida Alves [UNIFESP], Nogueira-de-Souza, Naiara Corrêa [UNIFESP], Noronha, Samuel Marcos Ribeiro de [UNIFESP], Costa, Ana Maria Massad [UNIFESP], Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP], Carvalho, Cristina Valletta de [UNIFESP], Gomes, Mariano Tamura Vieira [UNIFESP], Linhares, Jose Juvenal [UNIFESP]   +7 more
core   +1 more source

Angiotensin II type 1 receptor expression in human breast tissues

, 1997
We demonstrate the expression of angiotensin II type 1 (AT1) receptors in normal and diseased human breast tissues. Using monoclonal antibody 6313/G2, directed against a specific sequence in the extracellular domain of the AT1 receptor ...
INWANG ER, GOODE AW, HO MM, PAYNE JG, BROWN CL, VINSON GP, PUDDEFOOT JR, MARSIGLIANTE, Santo   +7 more
core   +1 more source