Results 111 to 120 of about 282,052 (348)

Advancing next-generation brain organoid platforms for investigating traumatic brain injury from repeated blast exposures

open access: yesFrontiers in Bioengineering and Biotechnology
Service members and law enforcement personnel are frequently exposed to blast overpressure during training and combat due to the use of heavy weaponry such as large-caliber rifles, explosives, and ordnance.
Eyal Bar-Kochba   +10 more
doaj   +1 more source

Novel computational models offer alternatives to animal testing for assessing eye irritation and corrosion potential of chemicals

open access: gold, 2021
Arthur C. Silva   +8 more
openalex   +1 more source

On the Origin of Risk Sensitivity: the Energy Budget Rule Revisited

open access: yes, 2015
The risk-sensitive foraging theory formulated in terms of the (daily) energy budget rule has been influential in behavioural ecology as well as other disciplines.
Lim, Ik Soo   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Bioethics: a look at animal testing in medicine and cosmetics in the UK

open access: yesJournal of Medical Ethics and History of Medicine, 2019
Using animals for cosmetics and medical tests has contributed towards a debate based on conflicting interests. Despite the efforts in justifying the value of animals in conducting analyses, this study seeks to elaborate whether or not it is rational to ...
Stefane Kabene, Said Baadel
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Designing choice experiments to Test for Anchoring and Framing Effects [PDF]

open access: yes
Choice experiments (CE) are increasingly used as a stated preference technique to value changes in non-market goods. Respondents to a CE survey are asked to make repeated choices between alternatives.
Bennett, Jeffrey W., Kragt, Marit Ellen
core   +1 more source

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