Results 121 to 130 of about 9,634,082 (235)

Identification and characterization of cell adhesion molecules controlling synapse stability [PDF]

, 2012
Neuronal circuits form the basis of a functional nervous system to process and integrate information and to react to environmental cues. The formation of functional synaptic connections between neurons is essential for the establishment of these circuits.
Enneking, Eva-Maria
core   +1 more source

Genetic risk factors in Finnish patients with Fuchs endothelial corneal dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To study the genetic risk factors of Fuchs endothelial corneal dystrophy (FECD) in the Finnish population using hospital‐based and large biobank cohorts. Methods We genotyped a cohort of 107 Finnish patients with FECD for the primary associated genetic risk factor, the TCF4 (CTG)>50 expansion, and studied their clinical phenotype.
Inka‐Tuulevi Vähämäki, Annamari T. Immonen, Joel T. Rämö, Aino M. Jaakkola, Kari Krootila, Maria Kaukonen, FinnGen, Aarno Palotie, Hannes Lohi, Tero T. Kivelä, Joni A. Turunen   +10 more
wiley   +1 more source

Fibroblasts as a Window into the Cell Biology of Ankyrin -B and -G

, 2011
The ankyrin family of proteins form specialized membrane domains in various cell types, including neurons and cardiomyocytes but little is known about how this process occurs. The majority of ankyrins localize to the plasma membrane in these cells while
Dowless, Kayla M.
core  

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen-induced arthritis

Arthritis Research & Therapy, 2018
Background Functional variants of the B cell gene, B cell scaffold protein with ankyrin repeats 1 (BANK1) contribute to rheumatoid arthritis (RA) susceptibility, but their influences on B cell responses are unclear.
Jie Yang, Jie Ren, Yiming Yang, Juan Sun, Xiaohui Zhou, Shucong Zheng, Dandan Xuan, Yu Xue, Huimin Fan, Jiong Zhang, Hejian Zou, Weiguo Wan, Ning Kong   +12 more
doaj   +1 more source

Spectrins and ankyrin distribution in the glomerulus.

, 2016
ImmunoEM micrographs of spectrin and ankyrin in the glomerulus. Spectrin βΙΙ staining was largely confined to endothelial cells. Spectrin βΙΙΙ was present in both endothelial cells (arrow head) and podocytes (arrow).
Michael C. Stankewich (842238), Thomas Ardito (842241), Lan Ji (842240), Gilbert W. Moeckel (842239), Jon S. Morrow (842242)   +4 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Self‐limited familial focal epilepsy caused by ANK2 variants: A potentially under‐recognized condition

Epilepsia Open
The Ankyrin 2 (ANK2) gene encodes the ankyrin‐B protein (ANKB), which is involved in the organization and stability of membrane ion channels, transporters, and receptors in cardiomyocytes and neurons. Variants in ANK2 genes are initially reported in long
Po‐Hsi Lin, Chen‐Jui Ho, Chih‐Hsiang Lin, Ya‐Yuan Hou, Cheng‐Han Chan, Meng‐Han Tsai   +5 more
doaj   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Sequence and structural alignments reveal insights into ANKLE2 evolution and function. [PDF]

Protein Sci
Abstract ANKLE2 is an enigmatic protein with emerging roles in cell division, development, and virus replication. While ANKLE2 orthologs are present in all animals, its domain composition has evolved over time. ANKLE2's two namesake domains, the ankyrin repeat and LEM domains (named for LAP2, Emerin, and MAN1), have clear and defined roles; however ...
Fishburn AT, Florio CJ, Skawinski CLS, Becker SS, Holleman E, Robertson AE, Sitchon R, Chédin F, Shah PS.   +8 more
europepmc   +2 more sources