Results 131 to 140 of about 9,634,082 (235)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber +8 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Mechanistic studies of ankyrin autoinhibition and ankyrin-spectrin complex formation
, 2017 Ankyrins coordinate with spectrins in excitable or mechano-resistant tissues/cells to organize various functional membrane domains, and thereby to promote structural stabilities and to regulate physiological activities including fast signaling in heart ...
Chen, Keyu
core
NCX1, NKA, and InsP3R Localization Require Ankyrin-B
, 2013 Boxes in differential interference contrast images (A and B) represent sites that were imaged in (C–F). Immunolocalization of ankyrin-B (red) and (C) DHPR (green), (D) InsP3R (green), (E) NCX1 (green), and (F) NKA (green) in wild-type (left) and ankyrin ...
Vann Bennett (12418) +2 more
core +1 more source
Clinical Endocrinology, EarlyView.ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore +6 more
wiley +1 more source
Chinese Journal of TraumatologyPurpose: To identify the potential target genes of blast lung injury (BLI) for the diagnosis and treatment. Methods: This is an experimental study. The BLI models in rats and goats were established by conducting a fuel-air explosive power test in an ...
Hong Wang +7 more
doaj +1 more source
Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response
The FEBS Journal, EarlyView.Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril +2 more
wiley +1 more source
JACC: Basic to Translational ScienceSummary: Arrhythmogenic cardiomyopathy (ACM) is an inherited heart disease, and current pharmacological therapies are directed toward the management of electrical manifestations.
Nipun Malhotra, MSc +16 more
doaj +1 more source
A case series of Brugada syndrome with a novel mutation in the ankyrin-B gene: an unusual unmasking in acute myocarditis. [PDF]
Eur Heart J Case Rep, 2021 Marketou ME +4 more
europepmc +1 more source
International Journal of Laboratory Hematology, EarlyView.ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari +6 more
wiley +1 more source