Results 121 to 130 of about 42,034 (274)
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
wiley +1 more source
The Journal of Cell Biology, 2001 ![][1] Ankyrin-G (green) helps cluster βIV spectrin (red) and others. Axon initial segments are specialized microdomains that integrate neuronal inputs and initiate action potentials.
openaire +2 more sources
Protein levels of ankyrin-1 analysis.
, 2012 (A) Immunoblot of erythrocytic ankyrin-1 in wt, Ank-1MRI23420/+, and Ank-1MRI23420/2340 mice with the N-terminal antibody ANK-1 p89. Quantification of the intensity of bands by densitometry for full-size ankyrin-1 (210 kDa) (B) and the truncated species (
Brendan J. McMorran (157276) +8 more
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber +8 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
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Nature CommunicationsMitochondrial dynamics enable cellular adaptation to fluctuations in energy demand, such as those imposed on skeletal muscle by exercise, metabolic disorders, or aging.
Kayleigh M. Voos +9 more
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British Journal of Pharmacology, EarlyView.Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
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X-ray induces mechanical and heat allodynia in mouse via TRPA1 and TRPV1 activation
Molecular Pain, 2019 Radiotherapy-related pain is a common adverse reaction with a high incidence among cancer patients undergoing radiotherapy and remarkably reduces the quality of life. However, the mechanisms of ionizing radiation-induced pain are largely unknown. In this
Su Cun-Jin +9 more
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Folding and design of ankyrin repeat proteins
, 2004 The ankyrin repeat is one of the most frequently occurring amino acid repeats in nature. This 33-residue motif is typically arranged in tandem repeats that stack against one another to form the underlying scaffold for many protein-protein interactions ...
Mosavi, Leila K
core
Cholinergic Augmentation of Insulin Release Requires Ankyrin-B
, 2010 Parasympathetic stimulation of pancreatic islets augments glucose-stimulated insulin secretion by inducing inositol trisphosphate receptor (IP3R)-mediated calcium ion (Ca2+) release.
Davis, Jonathan +10 more
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