Results 131 to 140 of about 36,997 (223)

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4610-4627, August 2026.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber   +8 more
wiley   +1 more source

Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior. [PDF]

open access: yesProc Natl Acad Sci U S A
Li M   +11 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Transient Hyperparathyroidism and Severe Intrauterine Osteopenia Linked to Novel Homozygous TRPV6 Deletion

open access: yesClinical Endocrinology, Volume 105, Issue 2, Page 197-204, August 2026.
ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore   +6 more
wiley   +1 more source

Oncolytic myxoma virus and engineering strategies for advanced cancer immunotherapy. [PDF]

open access: yesiScience
Trujillo Yeriomenko AD   +5 more
europepmc   +1 more source

Clinical and Genetic Characterization of 269 Patients With Suspected Inherited Platelet Disorders: The Padua Monocentric Experience

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 4, Page 856-865, August 2026.
ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari   +6 more
wiley   +1 more source

14‐3‐3 proteins: Central hubs in plant development and stress adaptation

open access: yesJournal of Integrative Plant Biology, Volume 68, Issue 8, Page 3107-3132, August 2026.
This review highlights recent advances elucidating the important roles of 14‐3‐3 proteins in regulating phytohormone networks, biotic and abiotic stress tolerance, growth‐defense trade‐offs, and evolutionary adaptations. Furthermore, it provides a forward‐looking perspective on 14‐3‐3 biology and the development of climate‐resilient smart crops under ...
Jiale Yuan   +6 more
wiley   +1 more source

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