Results 131 to 140 of about 42,034 (274)

Transient Hyperparathyroidism and Severe Intrauterine Osteopenia Linked to Novel Homozygous TRPV6 Deletion

Clinical Endocrinology, EarlyView.
ABSTRACT Context Placental calcium (Ca2+) transport is essential for foetal bone mineralisation and development, as well as for Ca2+ homoeostasis. Rare mutations in transient receptor potential vanilloid (TRPV) 6 of the infant cause insufficient maternal‐foetal Ca2+ transport through the placenta.
Teodora Grigore, Quinty Leusink, Femke Latta, Bram van der Eerden, Paul de Laat, Danielle van der Kaay, Joost Hoenderop   +6 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Elucidation of the interactions between band 3 and ankyrin

, 2011
The erythrocyte membrane is primarily linked to the spectrin-based cytoskeleton through association of band 3 with both ankyrin and adducin. Both interactions are critical for membrane stability and erythrocyte morphology.
Grey, Jesse Lou
core  

Clinical and Genetic Characterization of 269 Patients With Suspected Inherited Platelet Disorders: The Padua Monocentric Experience

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Inherited platelet disorders (IPDs) are rare hematologic conditions encompassing a heterogeneous spectrum of quantitative and qualitative platelet defects, frequently associated with variable clinical phenotypes and comorbidities. Accurate diagnosis necessitates comprehensive genetic characterization, detailed clinical and bleeding ...
Silvia Ferrari, Daniela Regazzo, Antonella Bertomoro, Anna Cerbo, Alessandro Galbiati, Elisabetta Cosi, Paolo Simioni   +6 more
wiley   +1 more source

Repetitive DNA sequences and ankyrin repeat domain number polymorphism.

, 2013
The example of WD0766. A) Only the ankyrin repeat domain containing regions are shown. Blue rectangles represent individual ankyrin repeat domains. Dark gray rectangles with dotted outline represent ankyrin repeat domain remnants.
Stefanos Siozios (60097), Siv G. E. Andersson (14688), Panagiotis Ioannidis (60095), Henk R. Braig (45662), Kostas Bourtzis (60101), Lisa Klasson (81256)   +5 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability.

PLoS Pathogens
Poxviruses are large DNA viruses with an arsenal of immune-modulatory genes, many of which remain uncharacterized. Proteins with ankyrin repeats are distinct features of poxviruses, although the biological functions of ankyrin proteins are not fully ...
Shijie Xie, Yongxiang Fang, Zhiyi Liao, Lianxin Cui, Kang Niu, Shuning Ren, Junda Zhu, Wenxue Wu, Zhizhong Jing, Chen Peng   +9 more
doaj   +1 more source

AIS Kv channel concentration is dependent on ankyrin G.

, 2013
Confocal microscopy photomicrographs show that interference RNAs against ankyrin G impair the concentration of Kv1.2 and Kv2.2 at the AIS. Before plating, hippocampal neurons were nucleofected with plasmids expressing scrambled shRNA (A–C, G–I) or ...
Alberto Muñoz (16533), Diana Sánchez-Ponce (301210), Javier DeFelipe (95458), Juan José Garrido (5650513)   +3 more
core   +1 more source

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

Ankyrin-spectrin scaffolds, from blood to brain

, 2006
The initiation and rapid transduction of electrical signals in the nervous system depends on the proper expression of voltage-gated sodium channels in the axon initial segment and nodes of Ranvier. The localization of sodium channel in neurons depends on
Yang, Yang
core