Results 171 to 180 of about 46,290 (201)
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Current Medicinal Chemistry, 1998
This review summarizes the structure, the occurrence and the available data concerning the bioactivity of biosynthetic anthracyclines. The anthracyclines represent an important family of natural products produced by microorganisms of Streptomyces and related genera and include clinically useful agents for the medical treatment of human cancer.
F, Arcamone, G, Cassinelli
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This review summarizes the structure, the occurrence and the available data concerning the bioactivity of biosynthetic anthracyclines. The anthracyclines represent an important family of natural products produced by microorganisms of Streptomyces and related genera and include clinically useful agents for the medical treatment of human cancer.
F, Arcamone, G, Cassinelli
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Pediatric Cardiology, 1982
Life-threatening irreversible cardiomyopathy is a major complication of anthracycline therapy, particularly in the pediatric population. The pediatric cardiologist, in concert with the primary oncologist, should therefore play a major role in the care of patients receiving these agents and in clinical trials involving their use.
N L, Kobrinsky, N K, Ramsay, W, Krivit
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Life-threatening irreversible cardiomyopathy is a major complication of anthracycline therapy, particularly in the pediatric population. The pediatric cardiologist, in concert with the primary oncologist, should therefore play a major role in the care of patients receiving these agents and in clinical trials involving their use.
N L, Kobrinsky, N K, Ramsay, W, Krivit
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Morpholinyl anthracyclines: Option for reversal of anthracycline resistance
European Journal of Cancer and Clinical Oncology, 1990Anthracyclines are potent chemotherapeutic drugs, consisting of a 4-ring aglycon and an aminosugar, which both can be substituted. The most widely used are doxorubicin and daunorubicin, the parent drugs. The efficacy, toxicity and drug resistance may be related to different parts of the anthracycline molecule.
de VRIES, Elisabeth GE, Zijlstra, Jan G
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2007
The clinical use of doxorubicin and other quinone-hydroquinone anticancer anthracyclines is limitedby a dose-related cardiotoxicity. Here, we review the correlation of cardiotoxicity of doxorubicinwith its peak plasma concentration and diffusion in the heart, followed by reductive bioactivation or oxidativeinactivation.
Pierantonio, Menna +3 more
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The clinical use of doxorubicin and other quinone-hydroquinone anticancer anthracyclines is limitedby a dose-related cardiotoxicity. Here, we review the correlation of cardiotoxicity of doxorubicinwith its peak plasma concentration and diffusion in the heart, followed by reductive bioactivation or oxidativeinactivation.
Pierantonio, Menna +3 more
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Anthracyclines and Mitochondria
2011Anthracyclines remain the cornerstone in the treatment of many malignancies including lymphomas, leukaemias, and sarcomas. Unfortunately, the clinical use of these potent chemotherapeutics is severely limited by the development of a progressive dose-dependent cardiomyopathy that irreversibly evolves toward congestive heart failure.
Mordente, Alvaro +4 more
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[Anthracycline cardiotoxicity].
La Clinica terapeutica, 2003To provide specialists and general practitioners with a review of the more recent data about anthracycline-induced cardiotoxicity and diagnostic methods utilized to reveal it.Reviewers identified studies concerning anthracycline cardiotoxicity, with special emphasis to those dealing with its pathogenesis and tools utilized for diagnosing it, by ...
FINOLEZZI E +3 more
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Cancer chemotherapy and biological response modifiers, 1990
After twenty years, understanding the mechanisms of tumor cells kill by anthracyclines still remains an active area of research. Of many mechanisms described for this class of drugs, efforts in the last year have focused on defining the role of free radical formation, topoisomerase II-induced DNA breakage, and P-170-dependent cellular accumulation of ...
B K, Sinha, P M, Politi
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After twenty years, understanding the mechanisms of tumor cells kill by anthracyclines still remains an active area of research. Of many mechanisms described for this class of drugs, efforts in the last year have focused on defining the role of free radical formation, topoisomerase II-induced DNA breakage, and P-170-dependent cellular accumulation of ...
B K, Sinha, P M, Politi
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Cardiotoxicity of Anthracyclines
Cardiology ClinicsAnthracycline chemotherapy is associated with cardiotoxicity, predominantly manifesting as left ventricular systolic dysfunction within the first year of treatment. Early detection is possible through biomarkers and cardiovascular imaging before clinical symptoms develop.
Elizabeth, Balough +3 more
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