The Ins and Outs of Anthrax Toxin. [PDF]
Toxins (Basel), 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Friebe S, van der Goot FG, Bürgi J.
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Anthrax Toxin Characterization [PDF]
Acta Medica, 2002 The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled.
Jiří Patočka, Miroslav Špliňo
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Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation. [PDF]
Toxins (Basel), 2016 Interaction between bacterial toxins and cellular surface receptors is an important component of the host-pathogen interaction. Anthrax toxin protective antigen (PA) binds to the cell surface receptor, enters the cell through receptor-mediated ...
Sun J, Jacquez P.
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In Vivo–produced Anthrax Toxin [PDF]
Journal of Bacteriology, 1968 Specific anthrax antigens were demonstrated in the blood of animals dying from anthrax. These antigens, which appear in the blood at the time when organisms are first detected and whose concentration continues to increase as the number of organisms increases, do not elicit a strong antibody response. The in vivo-produced toxin differs from the in vitro
Donald C. Fish, Ralph E. Lincoln
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Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics. [PDF]
Toxins (Basel), 2023 Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF), forming bipartite lethal toxin (LT) and edema toxin (ET).
Ouyang W, Xie T, Fang H, Frucht DM.
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Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin. [PDF]
iScience, 2022 Summary: The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released C-terminal Kunitz domain (C5) of the α3 chain is an adipokine important for tumor progression and fibrosis.
Przyklenk M +8 more
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Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas. [PDF]
Toxins (Basel), 2020 Canine oral mucosal melanomas (OMM) are the most common oral malignancy in dogs and few treatments are available. Thus, new treatment modalities are needed for this disease.
Nishiya AT +13 more
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Identification of Potential Therapeutic Targets Against Anthrax-Toxin-Induced Liver and Heart Damage. [PDF]
Toxins (Basel)Anthrax represents a disease resulting from infection by toxin-secreting bacteria, Bacillus anthracis. This research aimed to identify new therapeutic targets to combat anthrax.
Wu L +10 more
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Anthrax toxin translocation complex reveals insight into the lethal factor unfolding and refolding mechanism. [PDF]
Sci Rep, 2021 Translocation is essential to the anthrax toxin mechanism. Protective antigen (PA), the binding component of this AB toxin, forms an oligomeric pore that translocates lethal factor (LF) or edema factor, the active components of the toxin, into the cell ...
Machen AJ, Fisher MT, Freudenthal BD.
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Tumor Targeting and Drug Delivery by Anthrax Toxin. [PDF]
Toxins (Basel), 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Bachran C, Leppla SH.
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