Results 91 to 100 of about 19,635 (271)

The anthrax toxin channel: a barrel of LFs [PDF]

Journal of General Physiology, 2011
The use of anthrax as a model system dates back to the late 19th century and Koch’s initial investigations into the transmission of infectious diseases ([Koch, 1877][1]). These studies, coupled with his subsequent investigations into tuberculosis, enabled Koch to formulate the first set of ...
openaire   +3 more sources

A tetraspecific VHH-based neutralizing antibody modifies disease outcome in three animal models of Clostridium difficile infection [PDF]

, 2016
Clostridium difficile infection (CDI), a leading cause of nosocomial infection, is a serious disease in North America, Europe, and Asia. CDI varies greatly from asymptomatic carriage to life-threatening diarrhea, toxic megacolon, and toxemia.
Beamer, Gillian, Curiel, David T, Debatis, Michele, Dmitriev, Igor P, Kashentseva, Elena A, Kim, Hyeun Bum, Schmidt, Diane J, Shoemaker, Charles B, Steele, Jennifer A, Sun, Xingmin, Tremblay, Jacqueline M, Tzipori, Saul, Wang, Yaunkai   +12 more
core   +2 more sources

Genetic Insights Into Hyaline Fibromatosis Syndrome: A Case Report of an ANTXR2 Mutation Featuring a Rare Variant c.697+1G>A

Clinical Case Reports, Volume 13, Issue 4, April 2025.
ABSTRACT Hyaline fibromatosis syndrome (HFS) is a rare genetic disorder encompassing juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH), caused by mutations in the anthrax toxin receptor 2 gene (ANTXR2). This condition leads to the accumulation of hyaline plaques in the skin and organs, resulting in symptoms such as skin ...
Shabnam Hajiani Ghotbabadi, Reza Shiari, Shayan Yousufzai, Simin Sharifi   +3 more
wiley   +1 more source

The Disulfide Bond Cys255-Cys279 in the Immunoglobulin-Like Domain of Anthrax Toxin Receptor 2 Is Required for Membrane Insertion of Anthrax Protective Antigen Pore. [PDF]

PLoS ONE, 2015
Anthrax toxin receptors act as molecular clamps or switches that control anthrax toxin entry, pH-dependent pore formation, and translocation of enzymatic moieties across the endosomal membranes.
Pedro Jacquez, Gustavo Avila, Kyle Boone, Agamyrat Altiyev, Jens Puschhof, Roland Sauter, Emma Arigi, Blanca Ruiz, Xiuli Peng, Igor Almeida, Michael Sherman, Chuan Xiao, Jianjun Sun   +12 more
doaj   +1 more source

Shiga Toxin Detection Methods : A Short Review [PDF]

arXiv, 2013
The Shiga toxins comprise a family of related protein toxins secreted by certain types of bacteria. Shigella dysenteriae, some strain of Escherichia coli and other bacterias can express toxins which caused serious complication during the infection. Shiga toxin and the closely related Shiga-like toxins represent a group of very similar cytotoxins that ...
arxiv  

Single-species population models with age structure and psychological effect in a polluted environment [PDF]

arXiv, 2022
This paper considers a single-population model with age structure and psychological effects in a polluted environment. We divide the single population into two stages of larval and adult structure. The model uses Logistic input, and the larvae are converted into adult bodies by constant ratio. We only consider adulthood.
arxiv  

Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly [PDF]

, 2004
A panel of human anti-anthrax protective antigen IgG1 monoclonal antibodies were evaluated to determine the mechanism of toxin neutralization. AVP-22G12, AVP-1C6 and AVP-21D9 bound to the protective antigen with picomolar affinities to distinct non ...
Jiang, I., Jiang, I., Kang, A.S., Kang, A.S., Morrow, P.R., Morrow, P.R., Nedellec, R., Nedellec, R., Ruther, P., Ruther, P., Sawada-Hirai, R., Sawada-Hirai, R., Sun, S.M., Sun, S.M., Wang, F., Wang, F.   +15 more
core  

Three rare cases of anthrax arising from the same source [PDF]

, 2006
Anthrax is an acute bacterial infection caused by Bacillus anthracis. Humans become infected under natural conditions by contact with infected animals or contaminated animal products.
Abbas Arjmand, Brachman, Davies, Dixon, Doganay, Dutz, Farhang Babamahmoodi, Fereshteh Aghabarari, G. Hossein Ashrafi, Gleiser, His Majesty's Stationery Office, Holmes, Jena, Jernigan, Khhott, Lakshmi, Lew, Mckendrick, Meselson, Ndybahinduke, Siris Anthana, Tekin   +21 more
core   +1 more source

Defensin: The immune system regulatory factor against peripheral nerve disease

Brain‐X, Volume 3, Issue 1, March 2025.
Peripheral nerve disease is a common disorder that can lead to sensory, motor, and autonomic dysfunction, with common symptoms including pain, loss of sensation, lack of coordination, muscle weakness, and atrophy. Defensins (which can be divided into mammal, insect, and plant defensins), as regulatory factors of the immune system, can influence ...
Tiantian Qi, Qi Yang, Haotian Qin, Yuanchao Zhu, Jinyuan Chen, Hongfa Zhou, Jian Weng, Hui Zeng, Fei Yu   +8 more
wiley   +1 more source

Purification of the Third Factor of Anthrax Toxin [PDF]

Journal of General Microbiology, 1962
SUMMARY: Factor III of anthrax toxin, which increases the lethality of mixtures of factors I and II for mice and decreases their capacity to produce oedema in the skin of rabbits, has been purified. The final preparation showed a single peak in the ultracentrifuge and a single band on paper electro-phoresis.
H. Smith, J. L. Stanley
openaire   +3 more sources