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The Ins and Outs of Anthrax Toxin [PDF]
Toxins, 2016 Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the major virulence factors of the bacterium are its poly-γ-D-glutamic ...
Sarah Friebe +2 more
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Anthrax Toxin Characterization [PDF]
Acta Medica, 2002 The anthrax toxin comprises three proteins. When they work together, they can kill humans, especially after spores of the bacteria have been inhaled.
Jiří Patočka, Miroslav Špliňo
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LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]
PLoS Pathogens, 2007 Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young +8 more
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In Vivo–produced Anthrax Toxin [PDF]
Journal of Bacteriology, 1968 Specific anthrax antigens were demonstrated in the blood of animals dying from anthrax. These antigens, which appear in the blood at the time when organisms are first detected and whose concentration continues to increase as the number of organisms increases, do not elicit a strong antibody response. The in vivo-produced toxin differs from the in vitro
Donald C. Fish, Ralph E. Lincoln
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Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]
PLoS ONE, 2012 Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas +5 more
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Tumor Targeting and Drug Delivery by Anthrax Toxin [PDF]
Toxins, 2016 Anthrax toxin is a potent tripartite protein toxin from Bacillus anthracis. It is one of the two virulence factors and causes the disease anthrax.
Christopher Bachran, Stephen H. Leppla
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Anthrax toxin rafts into cells [PDF]
The Journal of Cell Biology, 2003 Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al.
Kurzchalia, Teymuras
core +6 more sources
Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]
PLoS Pathogens, 2006 Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie +8 more
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BMC Biotechnology, 2011 Background Anthrax is caused by the bacterium Bacillus anthracis and is regarded as one of the most prominent bioterrorism threats. Anthrax toxicity is induced by the tripartite toxin complex, composed of the receptor-binding anthrax protective antigen ...
Andersen Kasper +4 more
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Consequences and Utility of the Zinc-Dependent Metalloprotease Activity of Anthrax Lethal Toxin [PDF]
Toxins, 2010 Anthrax is caused by the gram-positive bacterium Bacillus anthracis. The pathogenesis of this disease is dependent on the presence of two binary toxins, edema toxin (EdTx) and lethal toxin (LeTx). LeTx, the major virulence factor contributing to anthrax,
Jennifer Bromberg-White +2 more
doaj +4 more sources