Results 31 to 40 of about 9,869 (220)

Targeted Silencing of Anthrax Toxin Receptors Protects against Anthrax Toxins [PDF]

Journal of Biological Chemistry, 2014
Anthrax spores can be aerosolized and dispersed as a bioweapon. Current postexposure treatments are inadequate at later stages of infection, when high levels of anthrax toxins are present. Anthrax toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2).
Maria T, Arévalo, Ashley, Navarro, Chenoa D, Arico, Junwei, Li, Omar, Alkhatib, Shan, Chen, Diana, Diaz-Arévalo, Mingtao, Zeng   +7 more
openaire   +2 more sources

Delayed toxicity associated with soluble anthrax toxin receptor decoy-Ig fusion protein treatment. [PDF]

PLoS ONE, 2012
Soluble receptor decoy inhibitors, including receptor-immunogloubulin (Ig) fusion proteins, have shown promise as candidate anthrax toxin therapeutics.
Diane Thomas, John Naughton, Christopher Cote, Susan Welkos, Marianne Manchester, John A T Young   +5 more
doaj   +1 more source

Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression

Toxins, 2015
Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility.
Zhang Zhang, Yan Zhang, Minglei Shi, Bingyu Ye, Wenlong Shen, Ping Li, Lingyue Xing, Xiaopeng Zhang, Lihua Hou, Junjie Xu, Zhihu Zhao, Wei Chen   +11 more
doaj   +1 more source

Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor

Toxins, 2016
Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li, Qiang Guo, Ju Liu, Jun Zhang, Ying Yin, Dayong Dong, Ling Fu, Junjie Xu, Wei Chen   +8 more
doaj   +1 more source

Anthrax lethal and edema toxins in anthrax pathogenesis [PDF]

Trends in Microbiology, 2014
The pathophysiological effects resulting from many bacterial diseases are caused by exotoxins released by the bacteria. Bacillus anthracis, a spore-forming bacterium, is such a pathogen, causing anthrax through a combination of bacterial infection and toxemia. B.
Shihui, Liu, Mahtab, Moayeri, Stephen H, Leppla   +2 more
openaire   +2 more sources

Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. [PDF]

PLoS ONE, 2014
CMG2-Fc is a fusion protein composed of the extracellular domain of capillary morphogenesis protein 2 (CMG2) and the Fc region of human immunoglobulin G; CMG2-Fc neutralizes anthrax toxin and offers protection against Bacillus anthracis challenge.
Yongyi Xi, Xiaojie Wu, Lihua Gao, Yong Shao, Hui Peng, Hongxing Chen, Huipeng Chen, Xianwen Hu, Junjie Yue   +8 more
doaj   +1 more source

Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model.

PLoS Pathogens, 2022
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr   +11 more
doaj   +1 more source

Designing inhibitors of anthrax toxin [PDF]

Expert Opinion on Drug Discovery, 2014
Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the ...
Ekaterina M, Nestorovich, Sergey M, Bezrukov   +1 more
openaire   +2 more sources

Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells [PDF]

Molecular Microbiology, 2006
Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by a third factor, protective antigen (PA), which binds ...
Francisco J, Maldonado-Arocho, Jennifer A, Fulcher, Benhur, Lee, Kenneth A, Bradley   +3 more
openaire   +2 more sources

Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1 [PDF]

Clinical and Experimental Immunology, 2013
Summary Anthrax is a toxin-mediated disease, the lethal effects of which are initiated by the binding of protective antigen (PA) with one of three reported cell surface toxin receptors (ANTXR). Receptor binding has been shown to influence host susceptibility to the toxins.
Ingram RJ, Harris A, Ascough S, Metan G, Doganay M, Ballie L, Williamson ED, Dyson H, Robinson JH, Sriskandan S, Altmann DM   +10 more
openaire   +5 more sources