Anthrax Susceptibility: Human Genetic Polymorphisms Modulating ANTXR2 Expression
Toxins, 2015 Anthrax toxin causes anthrax pathogenesis and expression levels of ANTXR2 (anthrax toxin receptor 2) are strongly correlated with anthrax toxin susceptibility.
Zhang Zhang +11 more
doaj +1 more source
Recombinant HSA-CMG2 Is a Promising Anthrax Toxin Inhibitor
Toxins, 2016 Anthrax toxin is the major virulence factor produced by Bacillus anthracis. Protective antigen (PA) is the key component of the toxin and has been confirmed as the main target for the development of toxin inhibitors.
Liangliang Li +8 more
doaj +1 more source
Effective antiprotease-antibiotic treatment of experimental anthrax [PDF]
, 2005 BACKGROUND: Inhalation anthrax is characterized by a systemic spread of the challenge agent, Bacillus anthracis. It causes severe damage, including multiple hemorrhagic lesions, to host tissues and organs.
Alibek, Ken +8 more
core +3 more sources
PLoS Pathogens, 2022 Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edema ...
Anne E Boyer +11 more
doaj +1 more source
Designing inhibitors of anthrax toxin. [PDF]
Expert Opin Drug Discov, 2014 Present-day rational drug design approaches are based on exploiting unique features of the target biomolecules, small- or macromolecule drug candidates and physical forces that govern their interactions. The 2013 Nobel Prize in chemistry awarded 'for the development of multiscale models for complex chemical systems' once again demonstrated the ...
Nestorovich EM, Bezrukov SM.
europepmc +5 more sources
Improving the anti-toxin abilities of the CMG2-Fc fusion protein with the aid of computational design. [PDF]
PLoS ONE, 2014 CMG2-Fc is a fusion protein composed of the extracellular domain of capillary morphogenesis protein 2 (CMG2) and the Fc region of human immunoglobulin G; CMG2-Fc neutralizes anthrax toxin and offers protection against Bacillus anthracis challenge.
Yongyi Xi +8 more
doaj +1 more source
Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed [PDF]
, 2004 BACKGROUND: Potent anthrax toxin neutralizing human monoclonal antibodies were generated from peripheral blood lymphocytes obtained from Anthrax Vaccine Adsorbed (AVA) immune donors.
Alvarez, A. +19 more
core +3 more sources
Coexistence of Competing Microbial Strains under Twofold Environmental Variability and Demographic Fluctuations [PDF]
New J. Phys 25, 123010 (2023), 2023 Microbial populations generally evolve in volatile environments, under conditions fluctuating between harsh and mild, e.g. as the result of sudden changes in toxin concentration or nutrient abundance. Environmental variability thus shapes the long-time population dynamics, notably by influencing the ability of different strains of microorganisms to ...
arxiv +1 more source
Toxin-mediated competition in weakly motile bacteria [PDF]
2019, J. Theor. Biol. 480 , 205-217, 2019 Many bacterial species produce toxins that inhibit their competitors. We model this phenomenon by extending classic two-species Lotka-Volterra competition in one spatial dimension to incorporate toxin production by one species. Considering solutions comprising two adjacent single-species colonies, we show how the toxin inhibits the susceptible species ...
arxiv +1 more source
Quantitative prediction of multivalent ligand–receptor binding affinities for influenza, cholera, and anthrax inhibition [PDF]
, 2018 Multivalency achieves strong, yet reversible binding by the simultaneous formation of multiple weak bonds. It is a key interaction principle in biology and promising for the synthesis of high-affinity inhibitors of pathogens. We present a molecular model
Liese, Susanne, Netz, Roland R.
core +2 more sources