Results 41 to 50 of about 9,869 (220)

The Receptors that Mediate the Direct Lethality of Anthrax Toxin

Toxins, 2012
Tumor endothelium marker-8 (TEM8) and capillary morphogenesis protein-2 (CMG2) are the two well-characterized anthrax toxin receptors, each containing a von Willebrand factor A (vWA) domain responsible for anthrax protective antigen (PA) binding ...
Stephen H. Leppla, Benjamin Hoover, Yi Zhang, Shihui Liu   +3 more
doaj   +1 more source

Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes.

PLoS ONE, 2020
Understanding immune responses to native antigens in response to natural infections can lead to improved approaches to vaccination. This study sought to characterize the humoral immune response to anthrax toxin components, capsule and spore antigens in ...
Eric K Dumas, Hayati Demiraslan, Rebecca J Ingram, Rebecca M Sparks, Emily Muns, Adriana Zamora, Jason Larabee, Lori Garman, Jimmy D Ballard, Geert-Jan Boons, Judith A James, Uner Kayabas, Mehmet Doganay, A Darise Farris   +13 more
doaj   +1 more source

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin. [PDF]

PLoS Pathogens, 2007
Anthrax toxin (AnTx) plays a key role in the pathogenesis of anthrax. AnTx is composed of three proteins: protective antigen (PA), edema factor, and lethal factor (LF). PA is not toxic but serves to bind cells and translocate the toxic edema factor or LF
John J Young, Jennifer L Bromberg-White, Cassandra Zylstra, Joseph T Church, Elissa Boguslawski, James H Resau, Bart O Williams, Nicholas S Duesbery, Nicholas S Duesbery   +8 more
doaj   +1 more source

Upstream sequence-dependent suppression and AtxA-dependent activation of protective antigens in Bacillus anthracis [PDF]

PeerJ, 2019
The anthrax toxin is a virulence factor produced by the bacterium Bacillus anthracis. Transcription of anthrax toxin genes is controlled by the transcription factor AtxA. Thus, AtxA is thought to be a key factor for the pathogenicity of B.
Kochi Toyomane, Yoshikazu Furuta, Daisuke Fujikura, Hideaki Higashi   +3 more
doaj   +2 more sources

Anthrax toxin receptor 2-dependent lethal toxin killing in vivo. [PDF]

PLoS Pathogens, 2006
Anthrax toxin receptors 1 and 2 (ANTXR1 and ANTXR2) have a related integrin-like inserted (I) domain which interacts with a metal cation that is coordinated by residue D683 of the protective antigen (PA) subunit of anthrax toxin. The receptor-bound metal
Heather M Scobie, Darran J Wigelsworth, John M Marlett, Diane Thomas, G Jonah A Rainey, D Borden Lacy, Marianne Manchester, R John Collier, John A T Young   +8 more
doaj   +1 more source

Current understanding of Bacillus anthracis toxin molecules organization and approaches for blocking their cytotoxic action

Инфекция и иммунитет, 2020
Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova, I. G. Shemyakin, I. A. Dyatlov   +2 more
doaj   +1 more source

Development of a multiple-antigen protein fusion vaccine candidate that confers protection against Bacillus anthracis and Yersinia pestis.

PLoS Neglected Tropical Diseases, 2019
Bacillus anthracis and Yersinia pestis are zoonotic bacteria capable of causing severe and sometimes fatal infections in animals and humans. Although considered as diseases of antiquity in industrialized countries due to animal and public health ...
Theresa B Gallagher, Gabriela Mellado-Sanchez, Ana L Jorgensen, Stephen Moore, James P Nataro, Marcela F Pasetti, Les W Baillie   +6 more
doaj   +1 more source

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. [PDF]

PLoS ONE, 2011
Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells.
Angelika Kronhardt, Monica Rolando, Christoph Beitzinger, Caroline Stefani, Michael Leuber, Gilles Flatau, Michel R Popoff, Roland Benz, Emmanuel Lemichez   +8 more
doaj   +1 more source

A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis

Scientific Reports, 2018
Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder, Shreya Das, Vikas Somani, Shivakiran S. Makam, Kingston J. Joseph, Rakesh Bhatnagar   +5 more
doaj   +1 more source

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

Frontiers in Cellular and Infection Microbiology, 2018
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu, Syed R. Ali, Ethan Bier, Victor Nizet, Victor Nizet   +4 more
doaj   +1 more source