Results 51 to 60 of about 9,869 (220)

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

open access: yesToxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse   +5 more
doaj   +1 more source

Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 2006
ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Mahtab, Moayeri   +3 more
openaire   +2 more sources

c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

open access: yesMicrobiology Spectrum
The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu   +3 more
doaj   +1 more source

Quantitative Assay for Crude Anthrax Toxins [PDF]

open access: yesJournal of Bacteriology, 1965
Haines, Bertram W. (U.S. Army Biological Laboratories, Frederick, Md.), Frederick Klein, and Ralph E. Lincoln . Quantitative assay for crude anthrax toxins. J. Bacteriol. 89: 74–83.
B W, HAINES, F, KLEIN, R E, LINCOLN
openaire   +2 more sources

Immunization with a Recombinant, Pseudomonas fluorescens-Expressed, Mutant Form of Bacillus anthracis-Derived Protective Antigen Protects Rabbits from Anthrax Infection. [PDF]

open access: yesPLoS ONE, 2015
Protective antigen (PA), one of the components of the anthrax toxin, is the major component of human anthrax vaccine (Biothrax). Human anthrax vaccines approved in the United States and Europe consist of an alum-adsorbed or precipitated (respectively ...
Matthew D Reed   +8 more
doaj   +1 more source

Membrane translocation by anthrax toxin [PDF]

open access: yesMolecular Aspects of Medicine, 2009
Much attention has been focused on anthrax toxin recently, both because of its central role in the pathogenesis of Bacillus anthracis and because it has proven to be one of the most tractable toxins for studying how enzymic moieties of intracellularly acting toxins traverse membranes.
openaire   +2 more sources

Mannose‐Modified Cationic Liposome‐Based mRNA Therapeutics for Improved Triple‐Negative Breast Cancer Immunotherapy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Schematic illustration of mTEM8‐loaded cationic liposome (cLipo‐Man/mTEM8) therapeutics for improved triple‐negative breast cancer immunotherapy. Despite triple‐negative breast cancer (TNBC) is the most heterogeneous and aggressive subtype of breast cancer, immunotherapy is emerging as a promising therapy.
Kexin Deng   +10 more
wiley   +1 more source

Mechanistic Insights Into Photocatalytic Materials for Toxic Pollutants: Environmental Remediation of Personal Care Products

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Photocatalytic materials have emerged as promising solutions for environmental applications due to their ability to degrade organic pollutants under sunlight or artificial light. In this review, recent progress on the photocatalytic materials used for the degradation of pharmaceutical personal care products (PPCPs) in environmental ...
Urvashi Sen   +5 more
wiley   +1 more source

Anthrax toxin rafts into cells [PDF]

open access: yesThe Journal of Cell Biology, 2003
Anthrax toxin binds to a plasma membrane receptor and after endocytosis exerts its deadly effects on the cell. Until now, however, the mechanism of initial toxin uptake was unknown. In this issue, Abrami et al. (2003) demonstrate that toxin oligomerization clusters the anthrax receptor into lipid rafts and this complex is internalized via the clathrin ...
openaire   +3 more sources

Micro/nanorobots for detecting and eliminating biological and chemical warfare agents

open access: yesBMEMat, EarlyView.
Fuel‐powered and field‐driven micro/nanorobots provide a cutting‐edge platform to safeguard national security and defense. This review reports the latest research progress in micro/nanorobots in sensing and detoxifying biological and chemical warfare agents.
Song Li   +4 more
wiley   +1 more source

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