Results 51 to 60 of about 19,635 (271)
CsrA and its regulators control the time-point of ColicinE2 release in Escherichia coli [PDF]
Scientific Reports 8, 6537 (2018), 2018 The bacterial SOS response is a cellular reaction to DNA damage, that, among other actions, triggers the expression of colicin - toxic bacteriocins in Escherichia coli that are released to kill close relatives competing for resources. However, it is largely unknown, how the complex network regulating toxin expression controls the time-point of toxin ...
arxiv +1 more source
Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte‐derived cells [PDF]
Molecular Microbiology, 2006 Summary Bacillus anthracis, the causative agent of anthrax, secretes two bipartite toxins that help the bacterium evade the immune system and contribute directly to pathogenesis. Both toxin catalytic moieties, lethal factor (LF) and oedema factor (OF), are internalized into the host‐cell cytosol by a third factor, protective antigen (PA), which binds ...
Benhur Lee +3 more
openaire +3 more sources
Инфекция и иммунитет, 2020 Here, we review the data on mechanisms inhibiting cytotoxic effect of anthrax toxin on the immune system cells. Various disease forms, immunopathogenesis and contemporary methods for anthrax treatment are discussed.
V. V. Firstova +2 more
doaj +1 more source
Environmental toxicity influences disease spread in consumer population [PDF]
arXiv, 2022 The study of infectious disease has been of interest to ecologists since long. The initiation of epidemic and the long term disease dynamics are largely influenced by the nature of the underlying consumer (host)-resource dynamics. Ecological traits of such systems may be often modulated by toxins released in the environment due to ongoing anthropogenic
arxiv
Pinpointing anthrax-toxin inhibitors [PDF]
Nature Biotechnology, 2002 Anthrax toxin consists of three components: protective antigen (PA), lethal factor (LF), and edema factor (EF). Individually, they are nontoxic.
Glick, Meir +2 more
openaire +2 more sources
Modeling sRNA-regulated Plasmid Maintenance [PDF]
, 2016 We study a theoretical model for the toxin-antitoxin (hok/sok) mechanism for plasmid maintenance in bacteria. Toxin-antitoxin systems enforce the maintenance of a plasmid through post-segregational killing of cells that have lost the plasmid. Key to their function is the tight regulation of expression of a protein toxin by an sRNA antitoxin.
arxiv +1 more source
Cisplatin Inhibition of Anthrax Lethal Toxin [PDF]
Antimicrobial Agents and Chemotherapy, 2006 ABSTRACT Bacillus anthracis lethal toxin (LT) produces symptoms of anthrax in mice and induces rapid lysis of macrophages derived from certain inbred strains. LT is comprised of a receptor binding component, protective antigen (PA), which delivers the enzymatic component, lethal factor (LF), into cells.
Robin E. Lindeman +3 more
openaire +3 more sources
Chemical warfare and survival strategies in bacterial range expansions [PDF]
J. R. Soc. Interface 11, 20140172 (2014), 2014 Dispersal of species is a fundamental ecological process in the evolution and maintenance of biodiversity. Limited control over ecological parameters has hindered progress in understanding of what enables species to colonise new area, as well as the importance of inter-species interactions.
arxiv +1 more source
Membrane translocation by anthrax toxin [PDF]
Molecular Aspects of Medicine, 2009 Much attention has been focused on anthrax toxin recently, both because of its central role in the pathogenesis of Bacillus anthracis and because it has proven to be one of the most tractable toxins for studying how enzymic moieties of intracellularly acting toxins traverse membranes.
openaire +3 more sources
PLoS Neglected Tropical Diseases, 2019 Bacillus anthracis and Yersinia pestis are zoonotic bacteria capable of causing severe and sometimes fatal infections in animals and humans. Although considered as diseases of antiquity in industrialized countries due to animal and public health ...
Theresa B Gallagher +6 more
doaj +1 more source