Results 61 to 70 of about 19,635 (271)

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells. [PDF]

PLoS ONE, 2011
Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells.
Angelika Kronhardt, Monica Rolando, Christoph Beitzinger, Caroline Stefani, Michael Leuber, Gilles Flatau, Michel R Popoff, Roland Benz, Emmanuel Lemichez   +8 more
doaj   +1 more source

A Review of the Efficacy of FDA-Approved B. anthracis Anti-Toxin Agents When Combined with Antibiotic or Hemodynamic Support in Infection- or Toxin-Challenged Preclinical Models

Toxins, 2021
Anti-toxin agents for severe B. anthracis infection will only be effective if they add to the benefit of the two mainstays of septic shock management, antibiotic therapy and titrated hemodynamic support.
Zoe Couse, Xizhong Cui, Yan Li, Mahtab Moayeri, Stephen Leppla, Peter Q. Eichacker   +5 more
doaj   +1 more source

A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. [PDF]

, 2020
Clostridium difficile infections (CDIs) cause severe and occasionally life-threatening diarrhea. Hyper-virulent strains produce CDT, a toxin that ADP-ribosylates actin monomers and inhibits actin polymerization.
Bier, Ethan, Franc, Nathalie C, Guichard, Annabel, Roy, Sitara, Schwartz, Ruth   +4 more
core  

Rapid Targeted Gene Disruption in Bacillus Anthracis [PDF]

, 2013
Anthrax is a zoonotic disease recognized to affect herbivores since Biblical times and has the widest range of susceptible host species of any known pathogen.
Ellington, Andrew, Kramer, Ryan, Lambowitz, Alan M., Lamkin, Thomas J., Pemberton, Adin, Perutka, Jiri, Saldanha, Roland J., Shiflett, Patrick, Taylor, Deborah, Whitt, Jacob T.   +9 more
core   +3 more sources

The toxins and antitoxins of symptomatic anthrax [PDF]

The Journal of Pathology and Bacteriology, 1897
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openaire   +2 more sources

c-di-AMP accumulation impairs toxin expression of Bacillus anthracis by down-regulating potassium importers

Microbiology Spectrum
The Gram-positive bacterium Bacillus anthracis is the causative agent of anthrax and a bioterrorism threat worldwide. As a crucial second messenger in many bacterial species, cyclic di-AMP (c-di-AMP) modulates various key processes for bacterial ...
Jia Hu, Junmin Yao, Chengfeng Lei, Xiulian Sun   +3 more
doaj   +1 more source

A bivalent protein r-PB, comprising PA and BclA immunodominant regions for comprehensive protection against Bacillus anthracis

Scientific Reports, 2018
Anthrax infection is primarily initiated by B. anthracis endospores that on entry into the host germinate to vegetative cells and cause severe bacteremia and toxaemia employing an array of host colonisation factors and the lethal tripartite toxin.
Saugata Majumder, Shreya Das, Vikas Somani, Shivakiran S. Makam, Kingston J. Joseph, Rakesh Bhatnagar   +5 more
doaj   +1 more source

Innate Immune Interactions between Bacillus anthracis and Host Neutrophils

Frontiers in Cellular and Infection Microbiology, 2018
Bacillus anthracis, the causative agent of anthrax, has been a focus of study in host-pathogen dynamics since the nineteenth century. While the interaction between anthrax and host macrophages has been extensively modeled, comparatively little is known ...
Janet Z. Liu, Syed R. Ali, Ethan Bier, Victor Nizet, Victor Nizet   +4 more
doaj   +1 more source

Receptors of anthrax toxin and cell entry [PDF]

Molecular Aspects of Medicine, 2009
Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation.
John A. T. Young, Gisou van der Goot
openaire   +2 more sources

Placental and Cord Blood DNA Methylation Changes Associated With Gestational Diabetes Mellitus in a Marginalized Population: The Untold Role of Saturated Fats

Molecular Nutrition &Food Research, EarlyView.
Excessive intake of saturated fats during pregnancy is associated with DNA hypomethylation in placental and cord blood samples from women affected with gestational diabetes mellitus (GDM), impacting, in particular, the cord blood promoter of ZFP57, a key regulator of early embryonic epigenetic programming.
Fatima Ahmad, Sidra Aftab Uzair, Arun P. Lakshmanan, Shaikha Alabduljabbar, Salma H. Ahmed, Basirudeen Syed Ahamed Kabeer, Alexandra Katharina Marr, Tomoshige Kino, Tobias Brummaier, Rose McGready, François Nosten, Damien Chaussabel, Souhaila Al Khodor, Annalisa Terranegra   +13 more
wiley   +1 more source