Results 61 to 70 of about 20,389 (266)
Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs [PDF]
, 2014 Bacterial toxin or viral entry into the cell often requires cell surface binding and endocytosis. The endosomal acidification induces a limited unfolding/refolding and membrane insertion reaction of the soluble toxins or viral proteins into their ...
Akkaladevi, Narahari +8 more
core +1 more source
Receptors of anthrax toxin and cell entry [PDF]
Molecular Aspects of Medicine, 2009 Anthrax toxin-receptor interactions are critical for toxin delivery to the host cell cytoplasm. This review summarizes what is known about the molecular details of the protective antigen (PA) toxin subunit interaction with either the ANTXR1 and ANTXR2 cellular receptors, and how receptor-type can dictate the low pH threshold of PA pore formation.
John A. T. Young, Gisou van der Goot
openaire +2 more sources
Early Recognition of Infantile Systemic Hyalinosis in a Palestinian Infant: A Case Report
Clinical Case Reports, Volume 13, Issue 10, October 2025.ABSTRACT Infantile systemic hyalinosis should be suspected in infants with contractures, skin changes, and diarrhea in consanguineous families. Early recognition allows timely genetic testing, supportive care, and counseling, improving family outcomes despite poor prognosis.
Lilyan Jarrar +6 more
wiley +1 more source
mBio, 2018 Toxin neutralizing antibodies represent the major mode of protective immunity against a number of toxin-mediated bacterial diseases, including anthrax; however, the cellular mechanisms that lead to optimal neutralizing antibody responses remain ill ...
Anita Verma +5 more
doaj +1 more source
Induction of autophagy by anthrax lethal toxin [PDF]
Biochemical and Biophysical Research Communications, 2009 Autophagy is an evolutionary conserved intracellular process whereby cells break down long-lived proteins and organelles. Accumulating evidences suggest increasing physiological significance of autophagy in pathogenesis of infectious diseases. Anthrax lethal toxin (LT) exerts its influence on numerous cells and herein, we report a novel effect of LT ...
Caroline M. Kusuma +5 more
openaire +3 more sources
MicrobiologyOpen, Volume 14, Issue 5, October 2025.Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem +4 more
wiley +1 more source
Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen [PDF]
, 2014 A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to
Akcay, Gizem +3 more
core +1 more source
Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome [PDF]
, 2020 Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome ...
Atmosukarto, Ines I. +21 more
core +5 more sources
A viral nanoparticle with dual function as an anthrax antitoxin and vaccine. [PDF]
PLoS Pathogens, 2007 The recent use of Bacillus anthracis as a bioweapon has stimulated the search for novel antitoxins and vaccines that act rapidly and with minimal adverse effects. B.
Darly J Manayani +12 more
doaj +1 more source
The toxins and antitoxins of symptomatic anthrax [PDF]
The Journal of Pathology and Bacteriology, 1897 n ...
openaire +2 more sources